ID Q9D3U9_MOUSE Unreviewed; 316 AA.
AC Q9D3U9;
DT 01-JUN-2001, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2001, sequence version 1.
DT 27-MAR-2024, entry version 172.
DE SubName: Full=Olfactory receptor 701 {ECO:0000313|EMBL:AAI10462.1};
DE SubName: Full=Olfactory receptor MOR283-1 {ECO:0000313|EMBL:AAL60688.1};
DE SubName: Full=Olfactory receptor Olfr701 {ECO:0000313|EMBL:AAP71166.1};
DE SubName: Full=Olfactory receptor family 2 subfamily AG member 2B {ECO:0000313|Ensembl:ENSMUSP00000074868.2};
GN Name=Or2ag2b {ECO:0000313|Ensembl:ENSMUSP00000074868.2,
GN ECO:0000313|MGI:MGI:3030535};
GN Synonyms=Olfr701 {ECO:0000313|EMBL:AAI10462.1,
GN ECO:0000313|MGI:MGI:3030535};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|EMBL:BAB30564.1};
RN [1] {ECO:0000313|EMBL:BAB30564.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAB30564.1};
RC TISSUE=Testis {ECO:0000313|EMBL:BAB30564.1};
RX PubMed=10349636; DOI=10.1016/S0076-6879(99)03004-9;
RA Carninci P., Hayashizaki Y.;
RT "High-efficiency full-length cDNA cloning.";
RL Methods Enzymol. 303:19-44(1999).
RN [2] {ECO:0000313|EMBL:BAB30564.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAB30564.1};
RC TISSUE=Testis {ECO:0000313|EMBL:BAB30564.1};
RX PubMed=11042159; DOI=10.1101/gr.145100;
RA Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M.,
RA Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.;
RT "Normalization and subtraction of cap-trapper-selected cDNAs to prepare
RT full-length cDNA libraries for rapid discovery of new genes.";
RL Genome Res. 10:1617-1630(2000).
RN [3] {ECO:0000313|EMBL:BAB30564.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAB30564.1};
RC TISSUE=Testis {ECO:0000313|EMBL:BAB30564.1};
RX PubMed=11076861; DOI=10.1101/gr.152600;
RA Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P.,
RA Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N.,
RA Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A., Yamamoto R.,
RA Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S.,
RA Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y.,
RA Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y.,
RA Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.;
RT "RIKEN integrated sequence analysis (RISA) system--384-format sequencing
RT pipeline with 384 multicapillary sequencer.";
RL Genome Res. 10:1757-1771(2000).
RN [4] {ECO:0000313|EMBL:BAB30564.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAB30564.1};
RC TISSUE=Testis {ECO:0000313|EMBL:BAB30564.1};
RA Adachi J., Aizawa K., Akahira S., Akimura T., Arai A., Aono H., Arakawa T.,
RA Bono H., Carninci P., Fukuda S., Fukunishi Y., Furuno M., Hanagaki T.,
RA Hara A., Hayatsu N., Hiramoto K., Hiraoka T., Hori F., Imotani K.,
RA Ishii Y., Itoh M., Izawa M., Kasukawa T., Kato H., Kawai J., Kojima Y.,
RA Konno H., Kouda M., Koya S., Kurihara C., Matsuyama T., Miyazaki A.,
RA Nishi K., Nomura K., Numazaki R., Ohno M., Okazaki Y., Okido T., Owa C.,
RA Saito H., Saito R., Sakai C., Sakai K., Sano H., Sasaki D., Shibata K.,
RA Shibata Y., Shinagawa A., Shiraki T., Sogabe Y., Suzuki H., Tagami M.,
RA Tagawa A., Takahashi F., Tanaka T., Tejima Y., Toya T., Yamamura T.,
RA Yasunishi A., Yoshida K., Yoshino M., Muramatsu M., Hayashizaki Y.;
RL Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|EMBL:BAB30564.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAB30564.1};
RC TISSUE=Testis {ECO:0000313|EMBL:BAB30564.1};
RX PubMed=11217851; DOI=10.1038/35055500;
RG The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium;
RT "Functional annotation of a full-length mouse cDNA collection.";
RL Nature 409:685-690(2001).
RN [6] {ECO:0000313|EMBL:AAL60688.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=11875048; DOI=10.1093/hmg/11.5.535;
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RT "Different evolutionary processes shaped the mouse and human olfactory
RT receptor gene families.";
RL Hum. Mol. Genet. 11:535-546(2002).
RN [7] {ECO:0000313|EMBL:AAL60688.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=11802173; DOI=10.1038/nn800;
RA Zhang X., Firestein S.;
RT "The olfactory receptor gene superfamily of the mouse.";
RL Nat. Neurosci. 5:124-133(2002).
RN [8] {ECO:0000313|EMBL:BAB30564.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAB30564.1};
RC TISSUE=Testis {ECO:0000313|EMBL:BAB30564.1};
RX PubMed=12466851; DOI=10.1038/nature01266;
RG The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team;
RT "Analysis of the mouse transcriptome based on functional annotation of
RT 60,770 full-length cDNAs.";
RL Nature 420:563-573(2002).
RN [9] {ECO:0000313|EMBL:AAL60688.1}
RP NUCLEOTIDE SEQUENCE.
RA Adams M.;
RL Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases.
RN [10] {ECO:0000313|EMBL:AAP71166.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=14611657; DOI=10.1186/gb-2003-4-11-r71;
RA Young J.M., Shykind B.M., Lane R.P., Tonnes-Priddy L., Ross J.A.,
RA Walker M., Williams E.M., Trask B.J.;
RT "Odorant receptor expressed sequence tags demonstrate olfactory expression
RT of over 400 genes, extensive alternate splicing and unequal expression
RT levels.";
RL Genome Biol. 4:R71.1-R71.13(2003).
RN [11] {ECO:0000313|EMBL:AAP71166.1}
RP NUCLEOTIDE SEQUENCE.
RA Sanders K.;
RL Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
RN [12] {ECO:0000313|EMBL:AAI10462.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=PCR rescued clones {ECO:0000313|EMBL:AAI10462.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M.,
RA Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.,
RA Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F.,
RA Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T.,
RA Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F.,
RA Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E.,
RA Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y.,
RA Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E.,
RA Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y.,
RA Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W.,
RA Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J.,
RA Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W.,
RA Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J.,
RA Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I.,
RA Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U.,
RA Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A.,
RA Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [13] {ECO:0000313|EMBL:BAB30564.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAB30564.1};
RC TISSUE=Testis {ECO:0000313|EMBL:BAB30564.1};
RG The FANTOM Consortium;
RG Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group);
RT "The Transcriptional Landscape of the Mammalian Genome.";
RL Science 309:1559-1563(2005).
RN [14] {ECO:0000313|EMBL:BAB30564.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAB30564.1};
RC TISSUE=Testis {ECO:0000313|EMBL:BAB30564.1};
RX PubMed=16141073; DOI=10.1126/science.1112009;
RG RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium;
RT "Antisense Transcription in the Mammalian Transcriptome.";
RL Science 309:1564-1566(2005).
RN [15] {ECO:0000313|Ensembl:ENSMUSP00000074868.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000074868.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [16] {ECO:0000313|Ensembl:ENSMUSP00000074868.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000074868.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; BC110461; AAI10462.1; -; mRNA.
DR EMBL; AY073025; AAL60688.1; -; Genomic_DNA.
DR EMBL; AY317822; AAP71166.1; -; Genomic_DNA.
DR EMBL; AK017036; BAB30564.1; -; mRNA.
DR RefSeq; NP_083186.2; NM_028910.3.
DR RefSeq; XP_006508181.1; XM_006508118.3.
DR RefSeq; XP_017167724.1; XM_017312235.1.
DR IntAct; Q9D3U9; 1.
DR STRING; 10090.ENSMUSP00000151783; -.
DR PaxDb; 10090-ENSMUSP00000074868; -.
DR Ensembl; ENSMUST00000075414.8; ENSMUSP00000074868.2; ENSMUSG00000036744.14.
DR Ensembl; ENSMUST00000166880.3; ENSMUSP00000130958.2; ENSMUSG00000036744.14.
DR Ensembl; ENSMUST00000217739.2; ENSMUSP00000151783.2; ENSMUSG00000036744.14.
DR GeneID; 66786; -.
DR UCSC; uc009jae.1; mouse.
DR AGR; MGI:3030535; -.
DR CTD; 66786; -.
DR MGI; MGI:3030535; Or2ag2b.
DR VEuPathDB; HostDB:ENSMUSG00000036744; -.
DR eggNOG; ENOG502SIEP; Eukaryota.
DR GeneTree; ENSGT01090000259995; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR OMA; CMSWEIR; -.
DR OrthoDB; 3784606at2759; -.
DR TreeFam; TF337295; -.
DR BioGRID-ORCS; 66786; 1 hit in 73 CRISPR screens.
DR Proteomes; UP000000589; Chromosome 7.
DR Bgee; ENSMUSG00000036744; Expressed in spermatid and 23 other cell types or tissues.
DR GO; GO:0016020; C:membrane; ISA:MGI.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; ISA:MGI.
DR GO; GO:0050911; P:detection of chemical stimulus involved in sensory perception of smell; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISA:MGI.
DR GO; GO:0007608; P:sensory perception of smell; ISA:MGI.
DR CDD; cd15421; 7tmA_OR2T-like; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR PANTHER; PTHR26453; OLFACTORY RECEPTOR; 1.
DR PANTHER; PTHR26453:SF607; OLFACTORY RECEPTOR 701; 1.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Olfaction {ECO:0000256|ARBA:ARBA00022725};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:AAI10462.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Sensory transduction {ECO:0000256|ARBA:ARBA00022606};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 29..49
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 61..78
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 98..120
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 141..162
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 197..225
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 237..261
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 273..292
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 41..290
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
SQ SEQUENCE 316 AA; 34917 MW; C2C5338B675D3225 CRC64;
MEPWNSTLES GFILVGILDG SGSPELLCAT VTTLYMLALI SNGLLLLVIT VDARLHVPMY
LLLRQLSLID LLFTSVVTPN TVVDFLLRDN TISFEGCALQ LFSAMTLGGA EDLLLAFMAY
DRYVAICHPL NYMIFMSPKA CRLMVAISWI LASLSALGHT VYTMHFPFCM SQEIRHLLCE
VPPLLKLACA DTSQYELMVY VTGVIFLLLP LSAIITSYSL ILFTVLHMPS NEGRKKALVT
CSSHLTVVGM FYGGATFMYV LPSSFHSPKQ DNIISVFYTI VTPALNPLIY SLRNKEVIGA
VRRVLGRHIL PAHATV
//
