ID Q9DDT7_CHICK Unreviewed; 307 AA.
AC Q9DDT7; F1NPD8;
DT 01-MAR-2001, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2001, sequence version 1.
DT 27-MAR-2024, entry version 146.
DE RecName: Full=Solute carrier family 25 member 8 {ECO:0000256|ARBA:ARBA00042368};
GN Name=UCP3 {ECO:0000313|Ensembl:ENSGALP00010003630.1};
GN Synonyms=UCP {ECO:0000313|EMBL:AAL35325.2};
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031 {ECO:0000313|EMBL:AAG48942.1};
RN [1] {ECO:0000313|EMBL:AAG48942.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Muscle {ECO:0000313|EMBL:AAG48942.1};
RX PubMed=11171038; DOI=10.1042/0264-6021:3530441;
RA Raimbault S., Dridi S., Denjean F., Lachuer J., Couplan E., Bouillaud F.,
RA Bordas A., Duchamp C., Taouis M., Ricquier D.;
RT "An uncoupling protein homologue putatively involved in facultative muscle
RT thermogenesis in birds.";
RL Biochem. J. 353:441-444(2001).
RN [2] {ECO:0000313|EMBL:AAL35325.2}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Blood {ECO:0000313|EMBL:AAL35325.2};
RA Zhao J., Wang Q., Meng H., Gu Z., Li H.;
RT "Cloning and Sequencing of Uncoupling Protein Gene in Chicken.";
RL Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSGALP00010003630.1}
RP IDENTIFICATION.
RC STRAIN=broiler {ECO:0000313|Ensembl:ENSGALP00010003630.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000256|ARBA:ARBA00006375, ECO:0000256|RuleBase:RU000488}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF287144; AAG48942.1; -; mRNA.
DR EMBL; AF433170; AAL35325.2; -; Genomic_DNA.
DR RefSeq; NP_989438.1; NM_204107.1.
DR RefSeq; XP_015136450.1; XM_015280964.1.
DR STRING; 9031.ENSGALP00000027932; -.
DR PaxDb; 9031-ENSGALP00000027932; -.
DR Ensembl; ENSGALT00010005841.1; ENSGALP00010003630.1; ENSGALG00010002543.1.
DR GeneID; 373896; -.
DR KEGG; gga:373896; -.
DR CTD; 7352; -.
DR VEuPathDB; HostDB:geneid_373896; -.
DR eggNOG; KOG0753; Eukaryota.
DR GeneTree; ENSGT00940000161030; -.
DR HOGENOM; CLU_015166_14_2_1; -.
DR OMA; RYMNAGP; -.
DR OrthoDB; 1832865at2759; -.
DR Reactome; R-GGA-167826; The fatty acid cycling model.
DR Reactome; R-GGA-167827; The proton buffering model.
DR Proteomes; UP000000539; Chromosome 1.
DR Bgee; ENSGALG00000017316; Expressed in muscle tissue and 6 other cell types or tissues.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:Ensembl.
DR GO; GO:0017077; F:oxidative phosphorylation uncoupler activity; IBA:GO_Central.
DR GO; GO:0015078; F:proton transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:1990845; P:adaptive thermogenesis; IBA:GO_Central.
DR GO; GO:0006631; P:fatty acid metabolic process; IEA:Ensembl.
DR GO; GO:1901373; P:lipid hydroperoxide transport; IEA:Ensembl.
DR GO; GO:1990542; P:mitochondrial transmembrane transport; IBA:GO_Central.
DR GO; GO:0009409; P:response to cold; IBA:GO_Central.
DR GO; GO:0000303; P:response to superoxide; IEA:Ensembl.
DR Gene3D; 1.50.40.10; Mitochondrial carrier domain; 1.
DR InterPro; IPR002067; Mit_carrier.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR PANTHER; PTHR45618; MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED; 1.
DR PANTHER; PTHR45618:SF1; MITOCHONDRIAL UNCOUPLING PROTEIN 2; 1.
DR Pfam; PF00153; Mito_carr; 3.
DR PRINTS; PR00784; MTUNCOUPLING.
DR SUPFAM; SSF103506; Mitochondrial carrier; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 2: Evidence at transcript level;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU00282}; Reference proteome {ECO:0000313|Proteomes:UP000000539};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU00282};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU000488}.
FT REPEAT 11..105
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT REPEAT 114..204
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT REPEAT 213..298
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
SQ SEQUENCE 307 AA; 33131 MW; 33AC1CD66FC1A9CD CRC64;
MVGLKPPEVP PTAAVKFFSA GTAACIADLC TFPLDTAKVR LQIQGEVRIP RSTNTVEYRG
VLGTLSTMVR TEGPRSLYSG LVAGLQRQMS FASIRIGLYD SVKQLYTPKG AESTGLLARL
LAGCTTGAVA VTCAQPTDVV KVRFQALGAL PESNRRYSGT VDAYRTIARE EGVRGLWRGT
LPNIARNSII NCGELVTYDL IKDTLLRAQL MTDNVPCHFV AAFGAGFCAT VVASPVDVVK
TRYMNASPGQ YRNVPSCLLA LLLQDGIAGL YKGFVPSFLR LGSWNVVMFI SYEQLQRVVM
LARSAPP
//
