ID Q9DFB2_XENLA Unreviewed; 907 AA.
AC Q9DFB2;
DT 01-MAR-2001, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2001, sequence version 1.
DT 27-MAR-2024, entry version 94.
DE SubName: Full=Armadillo repeat gene deletes in velo-cardio-facial syndrome {ECO:0000313|RefSeq:NP_001082029.1};
DE SubName: Full=Catenin arvcf-2ABC protein {ECO:0000313|EMBL:AAG00555.1};
GN Name=arvcf.L {ECO:0000313|RefSeq:NP_001082029.1,
GN ECO:0000313|Xenbase:XB-GENE-865889};
GN Synonyms=arvcf {ECO:0000313|RefSeq:NP_001082029.1}, p120
GN {ECO:0000313|RefSeq:NP_001082029.1}, Xarvcf
GN {ECO:0000313|RefSeq:NP_001082029.1};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|EMBL:AAG00555.1};
RN [1] {ECO:0000313|EMBL:AAG00555.1, ECO:0000313|RefSeq:NP_001082029.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=10899158; DOI=10.1074/jbc.M003048200;
RA Paulson A.F., Mooney E., Fang X., Ji H., McCrea P.D.;
RT "Xarvcf, Xenopus member of the p120 catenin subfamily associating with
RT cadherin juxtamembrane region.";
RL J. Biol. Chem. 275:30124-30131(2000).
RN [2] {ECO:0000313|RefSeq:NP_001082029.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12454917; DOI=10.1002/dvdy.10174;
RA Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA Richardson P.;
RT "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT initiative.";
RL Dev. Dyn. 225:384-391(2002).
RN [3] {ECO:0000313|RefSeq:NP_001082029.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=21062899;
RA Cho K., Vaught T.G., Ji H., Gu D., Papasakelariou-Yared C., Horstmann N.,
RA Jennings J.M., Lee M., Sevilla L.M., Kloc M., Reynolds A.B., Watt F.M.,
RA Brennan R.G., Kowalczyk A.P., McCrea P.D.;
RT "Xenopus Kazrin interacts with ARVCF-catenin, spectrin and p190B RhoGAP,
RT and modulates RhoA activity and epithelial integrity.";
RL J. Cell Sci. 123:4128-4144(2010).
RN [4] {ECO:0000313|RefSeq:NP_001082029.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=22028074;
RA Cho K., Lee M., Gu D., Munoz W.A., Ji H., Kloc M., McCrea P.D.;
RT "Kazrin, and its binding partners ARVCF- and delta-catenin, are required
RT for Xenopus laevis craniofacial development.";
RL Dev. Dyn. 240:2601-2612(2011).
RN [5] {ECO:0000313|RefSeq:NP_001082029.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=22028109;
RA Tran H.T., Delvaeye M., Verschuere V., Descamps E., Crabbe E.,
RA Van Hoorebeke L., McCrea P., Adriaens D., Van Roy F., Vleminckx K.;
RT "ARVCF depletion cooperates with Tbx1 deficiency in the development of
RT 22q11.2DS-like phenotypes in Xenopus.";
RL Dev. Dyn. 240:2680-2687(2011).
RN [6] {ECO:0000313|RefSeq:NP_001082029.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the beta-catenin family.
CC {ECO:0000256|ARBA:ARBA00005462}.
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DR EMBL; AF287051; AAG00555.1; -; mRNA.
DR RefSeq; NP_001082029.1; NM_001088560.1.
DR DNASU; 398186; -.
DR GeneID; 398186; -.
DR KEGG; xla:398186; -.
DR AGR; Xenbase:XB-GENE-865889; -.
DR CTD; 398186; -.
DR Xenbase; XB-GENE-865889; arvcf.L.
DR OrthoDB; 5473239at2759; -.
DR Proteomes; UP000186698; Chromosome 1L.
DR Bgee; 398186; Expressed in blastula and 19 other cell types or tissues.
DR GO; GO:0098609; P:cell-cell adhesion; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR028435; Plakophilin/d_Catenin.
DR PANTHER; PTHR10372:SF5; ARMADILLO REPEAT PROTEIN DELETED IN VELO-CARDIO-FACIAL SYNDROME; 1.
DR PANTHER; PTHR10372; PLAKOPHILLIN-RELATED; 1.
DR Pfam; PF00514; Arm; 4.
DR SMART; SM00185; ARM; 6.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50176; ARM_REPEAT; 3.
PE 2: Evidence at transcript level;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698}.
FT REPEAT 347..384
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 390..433
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 656..693
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 185..245
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 800..907
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 17..34
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 201..217
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 800..826
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 846..883
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 907 AA; 101573 MW; A3B9EF7A0E5B9B86 CRC64;
MMQEPPEMLE ETVTVEEDPG TPSSHVSVVT SDDGTTRRTE TKVTKMVKTV TTRTVRQVPL
GPDGVPVLDA SSPLSGYTDS IDRRYMKNGD RFVTPQATST LTRSYNNSYN DSYGDPHDTQ
YRPFLGHEGY GDIPDNYGSL SRGINYRPRY AYTPGNNYRP EDGSYTLPIR RENYVPIAQP
QVPIGSNIDL NRSQPERFQP EPYGLEDDNR SLGADDDGYE LDPDYSTMNR RVLPGMPLTG
RPHKARAYDD PLEADLIEER VPYLHGGYAA PLAQPERGSL ASIDRLGKRS PSIDSIRKDP
RWRDPDLPEV IAMLNHPIDP VKSNAAAYLQ HLCYENDKIK KDVRYLKGIP TLVGLLDHPK
PEVHRKACGA LRNISYGKDN ENKVAIKNCD GIPALIRLLR KTNDMEVREL ITGTLWNLSS
YEPLKMVIIN HGLQTLTNEV IIPHSGWENE PNEDSKPRDA EWSTVFKNTS GCLRNVSSDG
AEARRRLREC DGLVDALLHA LQSAVSKKDT DNKSVENCVC IMRNLSYHVH KEVPGADRFQ
ENELNQQGGI GGQQKKKKDD AGCFGGKKAK EEWFNQGKKN GDTDKNFDTL DLPKRSESAK
GFELLYQPEV VRLYLSILTE SQNYNTLEAA AGALQNLSAG NWTWSMYIRA TVRKERGLPV
LVELLQSDSD KVVRAVAIAL RNLSMDRRNK DLIGNYAMGQ LVRNLPGGQQ RPAKNLEEDT
VVAVLNTIHE IITDSSENAR SLIQSQGIEK LITINKSSQS PREVKAASHV LQMVWSYKEL
RGSLQKEGWN KANFQTAVST LPKGSKGNGK SGFDDSTLPL VDKSQVNKKS GSRDMIPMGE
LGPDGYSTID HRDKERKYRS NESMGDMSEK EPLKNDSNKK HITRSNRPTV NLVDARDTKP
QPVDSWV
//
