ID Q9DFB9_ICTPU Unreviewed; 390 AA.
AC Q9DFB9;
DT 01-MAR-2001, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2001, sequence version 1.
DT 27-MAR-2024, entry version 109.
DE RecName: Full=Transcriptional regulator {ECO:0000256|PIRNR:PIRNR001705};
GN Name=myc {ECO:0000313|EMBL:AAG14351.1,
GN ECO:0000313|RefSeq:NP_001187019.1};
GN Synonyms=myca {ECO:0000313|RefSeq:NP_001187019.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|EMBL:AAG14351.1};
RN [1] {ECO:0000313|EMBL:AAG14351.1}
RP NUCLEOTIDE SEQUENCE.
RA Barker K.S., Bengten E., Wilson M.R., Miller N.W., Warr G.W., Clem L.W.;
RT "Catfish myc oncogene.";
RL Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|RefSeq:NP_001187019.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23127152; DOI=10.1186/1471-2164-13-595;
RA Liu S., Zhang Y., Zhou Z., Waldbieser G., Sun F., Lu J., Zhang J.,
RA Jiang Y., Zhang H., Wang X., Rajendran K.V., Khoo L., Kucuktas H.,
RA Peatman E., Liu Z.;
RT "Efficient assembly and annotation of the transcriptome of catfish by RNA-
RT Seq analysis of a doubled haploid homozygote.";
RL BMC Genomics 13:595-595(2012).
RN [3] {ECO:0000313|RefSeq:NP_001187019.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Transcription factor that binds DNA in a non-specific manner,
CC yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'.
CC Activates the transcription of growth-related genes.
CC {ECO:0000256|ARBA:ARBA00003607, ECO:0000256|PIRNR:PIRNR001705}.
CC -!- SUBUNIT: Efficient DNA binding requires dimerization with another bHLH
CC protein. Binds DNA as a heterodimer with MAX.
CC {ECO:0000256|ARBA:ARBA00025872}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR001705}.
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DR EMBL; AF283994; AAG14351.1; -; mRNA.
DR RefSeq; NP_001187019.1; NM_001200090.1.
DR STRING; 7998.ENSIPUP00000005992; -.
DR GeneID; 100304504; -.
DR KEGG; ipu:100304504; -.
DR CTD; 30686; -.
DR OrthoDB; 3039999at2759; -.
DR Proteomes; UP000221080; Chromosome 23.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR CDD; cd11458; bHLHzip_c-Myc; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR003327; Myc-LZ.
DR InterPro; IPR002418; Tscrpt_reg_Myc.
DR InterPro; IPR012682; Tscrpt_reg_Myc_N.
DR PANTHER; PTHR45851; MYC PROTO-ONCOGENE; 1.
DR PANTHER; PTHR45851:SF1; MYC PROTO-ONCOGENE PROTEIN; 1.
DR Pfam; PF00010; HLH; 1.
DR Pfam; PF02344; Myc-LZ; 1.
DR Pfam; PF01056; Myc_N; 1.
DR PIRSF; PIRSF001705; Myc_protein; 1.
DR PRINTS; PR00044; LEUZIPPRMYC.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 2: Evidence at transcript level;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR001705};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Nucleus {ECO:0000256|PIRNR:PIRNR001705}.
FT DOMAIN 305..357
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT REGION 178..315
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 198..219
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 220..235
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 246..263
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 293..315
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 390 AA; 44696 MW; 2422D9A7DBD5D700 CRC64;
MPMSSGLAWK NYDYDYDSVQ PYFYFDNDEE DFYKQLQQGQ APSEDIWKKF ELLPTPPLSP
SRRPSTAEQL EIVSEFLGDD AVNQSFICDS DSSQTFLKSI IIQDCMWSGF SAVAKLEKVV
SESSRRCTRR GKAYPRLPVV MQRDSSGVYL HDLSASECID PSMVFPYALT ESPKCAKLTA
PADHAPPVDT PPNSGCSSDS DDEEEEDEED EEDDEEEIDV VTVEKRQRRS EAEVTESRQP
SPLVLKRCHV STQQHNYAAQ PSTRHEHPVS KRPRLETSST GHGTIRHSKP RKCTSPRTSD
SEDNDKRKTH NVLERQRRNE LKLSFFALRD EIPEVANNEK AAKVMILKKA AECIHSMQAD
ERRLLSMKEQ LRRKSELLKH RLQQLRRSQL
//
