ID Q9DG04_XENLA Unreviewed; 507 AA.
AC Q9DG04;
DT 01-MAR-2001, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2001, sequence version 1.
DT 27-MAR-2024, entry version 79.
DE SubName: Full=Natriuretic peptide receptor 3 L homeolog precursor {ECO:0000313|RefSeq:NP_001084234.1};
DE SubName: Full=Natriuretic peptide receptor type C NPR-C {ECO:0000313|EMBL:AAG17553.1};
GN Name=npr3.L {ECO:0000313|RefSeq:NP_001084234.1,
GN ECO:0000313|Xenbase:XB-GENE-1012473};
GN Synonyms=npr-c {ECO:0000313|RefSeq:NP_001084234.1}, npr3
GN {ECO:0000313|RefSeq:NP_001084234.1,
GN ECO:0000313|Xenbase:XB-GENE-1012473}, nprc
GN {ECO:0000313|RefSeq:NP_001084234.1};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|EMBL:AAG17553.1};
RN [1] {ECO:0000313|EMBL:AAG17553.1}
RP NUCLEOTIDE SEQUENCE.
RA Lelievre V., Hu Z., Ioffe Y., Chao A., Zhou X., Waschek J.A.;
RT "Molecular characterization of the natriuretic peptide(clearance)receptor
RT NPR-C in Xenopus.";
RL Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|RefSeq:NP_001084234.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12454917; DOI=10.1002/dvdy.10174;
RA Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA Richardson P.;
RT "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT initiative.";
RL Dev. Dyn. 225:384-391(2002).
RN [3] {ECO:0000313|RefSeq:NP_001084234.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR EMBL; AF231035; AAG17553.1; -; mRNA.
DR RefSeq; NP_001084234.1; NM_001090765.1.
DR GeneID; 399384; -.
DR KEGG; xla:399384; -.
DR AGR; Xenbase:XB-GENE-1012473; -.
DR CTD; 399384; -.
DR Xenbase; XB-GENE-1012473; npr3.L.
DR OrthoDB; 4523637at2759; -.
DR Proteomes; UP000186698; Chromosome 1L.
DR Bgee; 399384; Expressed in spleen and 12 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd06386; PBP1_NPR_C; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR001170; ANPR/GUC.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR44755:SF11; ATRIAL NATRIURETIC PEPTIDE RECEPTOR 3 ISOFORM X1; 1.
DR PANTHER; PTHR44755; NATRIURETIC PEPTIDE RECEPTOR 3-RELATED; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR PRINTS; PR00255; NATPEPTIDER.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00458; ANF_RECEPTORS; 1.
PE 2: Evidence at transcript level;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|EMBL:AAG17553.1, ECO:0000313|RefSeq:NP_001084234.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW Signal {ECO:0000256|SAM:SignalP, ECO:0000313|RefSeq:NP_001084234.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..507
FT /evidence="ECO:0000256|SAM:SignalP,
FT ECO:0000313|RefSeq:NP_001084234.1"
FT /id="PRO_5033206746"
FT TRANSMEM 449..470
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 46..391
FT /note="Receptor ligand binding region"
FT /evidence="ECO:0000259|Pfam:PF01094"
SQ SEQUENCE 507 AA; 57252 MW; 9830BEF50B4544E0 CRC64;
MSSMLLFSLM VTLVILAKSN PMDEDTVNML VLLPKDNSYM FSMDRVKPAI DHALSSIQEN
QTLLPGVHFN VIYNDSDCGN QALFSLIDIA MQLQKPDVIL GPVCEYAAAS VARLASHWNV
PMLSSGALAV GFMQKSSEYS HLTRVSPVYS KMGEMFLAMF RYHKWTKAFL LYTDDTQQRN
CFFTLEGVHL AFKEEGYAMS IHNFDETKHV DAEEIVHAIQ NKERVVIMCA SSDTVRNIML
AAHRQGMTNG DYVFFNIELF NSSTYGNGSW KRGDKYDLEA KQAYSSLQTV TLLRTVKPEF
EKFSMEVKSS VQKLGLNDDD YVNMFVEGFH DAIILYALAL HELLKNGFSQ KDGEKLVQQM
WNRTYEGIAG QVSIDANGDR YGDFSVIAMT DKETGTQEVI GDYYGIQGHF EIRPNVKLPW
GPGRLLINDR FVEHTNTTPC KSCGLGESAV TGIVVGALLG TGLLMAFYFF RKKYRITIER
RNQQDDCNLG KHRQLREDSI RSHFSAA
//
