ID Q9EWI2_STRCO Unreviewed; 195 AA.
AC Q9EWI2;
DT 01-MAR-2001, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2001, sequence version 1.
DT 27-MAR-2024, entry version 130.
DE SubName: Full=TetR-family transcriptional regulator {ECO:0000313|EMBL:CAC16523.1};
GN OrderedLocusNames=SCO7602 {ECO:0000313|EMBL:CAC16523.1};
GN ORFNames=SC7H9.14 {ECO:0000313|EMBL:CAC16523.1};
OS Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces; Streptomyces albidoflavus group.
OX NCBI_TaxID=100226 {ECO:0000313|EMBL:CAC16523.1, ECO:0000313|Proteomes:UP000001973};
RN [1] {ECO:0000313|EMBL:CAC16523.1, ECO:0000313|Proteomes:UP000001973}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-471 / A3(2) / M145
RC {ECO:0000313|Proteomes:UP000001973};
RX PubMed=12000953; DOI=10.1038/417141a;
RA Bentley S.D., Chater K.F., Cerdeno-Tarraga A.M., Challis G.L.,
RA Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.H.,
RA Kieser T., Larke L., Murphy L., Oliver K., O'Neil S., Rabbinowitsch E.,
RA Rajandream M.A., Rutherford K., Rutter S., Seeger K., Saunders D.,
RA Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA Woodward J., Barrell B.G., Parkhill J., Hopwood D.A.;
RT "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT A3(2).";
RL Nature 417:141-147(2002).
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DR EMBL; AL939132; CAC16523.1; -; Genomic_DNA.
DR RefSeq; NP_631644.1; NC_003888.3.
DR RefSeq; WP_003971542.1; NZ_VNID01000005.1.
DR AlphaFoldDB; Q9EWI2; -.
DR STRING; 100226.gene:17765262; -.
DR PaxDb; 100226-SCO7602; -.
DR PATRIC; fig|100226.15.peg.7718; -.
DR eggNOG; COG1309; Bacteria.
DR HOGENOM; CLU_069356_23_1_11; -.
DR InParanoid; Q9EWI2; -.
DR OrthoDB; 4214267at2; -.
DR PhylomeDB; Q9EWI2; -.
DR Proteomes; UP000001973; Chromosome.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IBA:GO_Central.
DR Gene3D; 1.10.357.10; Tetracycline Repressor, domain 2; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001647; HTH_TetR.
DR InterPro; IPR036271; Tet_transcr_reg_TetR-rel_C_sf.
DR PANTHER; PTHR30055; HTH-TYPE TRANSCRIPTIONAL REGULATOR RUTR; 1.
DR PANTHER; PTHR30055:SF226; HTH-TYPE TRANSCRIPTIONAL REPRESSOR RV1474C; 1.
DR Pfam; PF00440; TetR_N; 1.
DR PRINTS; PR00455; HTHTETR.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR SUPFAM; SSF48498; Tetracyclin repressor-like, C-terminal domain; 1.
DR PROSITE; PS50977; HTH_TETR_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00335};
KW Reference proteome {ECO:0000313|Proteomes:UP000001973};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 14..74
FT /note="HTH tetR-type"
FT /evidence="ECO:0000259|PROSITE:PS50977"
FT DNA_BIND 37..56
FT /note="H-T-H motif"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00335"
SQ SEQUENCE 195 AA; 21640 MW; 2C2766C1D63061F6 CRC64;
MTSTAARPGR VAKLPPRERI LDAAEELFQG EGIRRVGVQA IAERAETTKM AIYRHFETKD
ALVAEWLRIL AAEYQAAFDR VEAEHPGRPR EQILGLARFI ADGLPGLSHR GCPFINSLAE
LPDRSHPARR VIEEHKARQT RRLVGMCAEA GMPDPEQVAA QITFVLEGAQ VSTQNASIDR
AGERLMRIVE AIVDQ
//
