ID Q9EYV9_ENTFC Unreviewed; 323 AA.
AC Q9EYV9;
DT 01-MAR-2001, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2001, sequence version 1.
DT 27-MAR-2024, entry version 108.
DE SubName: Full=D-2-hydroxyacid dehydrogenase {ECO:0000313|EMBL:AAG34690.1};
DE SubName: Full=VanH {ECO:0000313|EMBL:AGG19363.1, ECO:0000313|EMBL:AHH83932.1};
DE SubName: Full=Vancomycin resistance protein VanH {ECO:0000313|EMBL:CCJ27776.1};
GN Name=vanHB2 {ECO:0000313|EMBL:AAG34690.1};
GN Synonyms=vanH {ECO:0000313|EMBL:AKJ75210.1}, vanHB
GN {ECO:0000313|EMBL:AHH83932.1};
OS Enterococcus faecium (Streptococcus faecium).
OG Plasmid pJEG050 {ECO:0000313|EMBL:AKJ75210.1}.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Enterococcaceae;
OC Enterococcus.
OX NCBI_TaxID=1352 {ECO:0000313|EMBL:AAG34690.1};
RN [1] {ECO:0000313|EMBL:AAG34690.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=TSGH1 {ECO:0000313|EMBL:AAG34690.1};
RA Lu J.-J., Perng C.-L., Ho M.-F., Lu C.-L.;
RL Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AAG34690.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=TSGH1 {ECO:0000313|EMBL:AAG34690.1};
RX PubMed=11376048; DOI=10.1128/JCM.39.6.2140-2145.2001;
RA Lu J.J., Perng C.L., Ho M.F., Chiueh T.S., Lee W.H.;
RT "High prevalence of VanB2 vancomycin-resistant Enterococcus faecium in
RT Taiwan.";
RL J. Clin. Microbiol. 39:2140-2145(2001).
RN [3] {ECO:0000313|EMBL:AGG19363.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=1349/02 {ECO:0000313|EMBL:AGG19406.1}, 2497/00
RC {ECO:0000313|EMBL:AGG19373.1}, 3587/04 {ECO:0000313|EMBL:AGG19383.1},
RC 3630/04 {ECO:0000313|EMBL:AGG19363.1}, 4207/05
RC {ECO:0000313|EMBL:AGG19368.1}, 765/05 {ECO:0000313|EMBL:AGG19388.1},
RC 822/05 {ECO:0000313|EMBL:AGG19378.1}, 8672/99
RC {ECO:0000313|EMBL:AGG19393.1}, and 8841/99
RC {ECO:0000313|EMBL:AGG19412.1};
RA Sadowy E., Sienko A., Gawryszewska I., Hryniewicz W.;
RT "Vancomycin-resistance determinants among Enterococcus faecium in Poland.";
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:CCJ27776.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=MM5-F9a {ECO:0000313|EMBL:CCJ27776.1};
RX PubMed=24078615; DOI=10.1128/JB.02165-12;
RA Bjorkeng E.K., Hjerde E., Pedersen T., Sundsfjord A., Hegstad K.;
RT "ICESluvan, a 94-Kilobase Mosaic Integrative Conjugative Element Conferring
RT Interspecies Transfer of VanB-Type Glycopeptide Resistance, a Novel
RT Bacitracin Resistance Locus, and a Toxin-Antitoxin Stabilization System.";
RL J. Bacteriol. 195:5381-5390(2013).
RN [5] {ECO:0000313|EMBL:AHH83932.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=SAU16 {ECO:0000313|EMBL:AHH83932.1};
RA Santona A., Al-Qahtani A.A., Paglietti B., Bohol M.F.F., Senok A.,
RA Deligios M., Rubino S., Al-Ahdal M.N.;
RT "Emerging of a new VanB teicoplanin-resistant Enterococcus faecium strain
RT in Saudi Arabia.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000313|EMBL:AHH83939.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=SAU28 {ECO:0000313|EMBL:AHH83939.1};
RX PubMed=25059441; DOI=10.1016/j.ijantimicag.2014.05.005;
RA Santona A., Paglietti B., Al-Qahtani A.A., Bohol M.F., Senok A.,
RA Deligios M., Rubino S., Al-Ahdal M.N.;
RT "Novel type of VanB2 teicoplanin-resistant hospital-associated Enterococcus
RT faecium.";
RL Int. J. Antimicrob. Agents 44:156-159(2014).
RN [7] {ECO:0000313|EMBL:AKJ75210.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Efm0123 {ECO:0000313|EMBL:AKJ75210.1};
RC PLASMID=pJEG050 {ECO:0000313|EMBL:AKJ75210.1};
RA van Hal S.J., Ip C.L.C., Ansari M.A., Wilson D.J., Espedido B.A.,
RA Jensen S.O., Bowden R.;
RT "Evolutionary Whole Genome Sequencing Analysis of Enterococcus faecium from
RT a Single Institution: the End of Multi-Locus Sequence Typing?";
RL Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC dehydrogenase family. {ECO:0000256|ARBA:ARBA00005854,
CC ECO:0000256|RuleBase:RU003719}.
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DR EMBL; AF310956; AAG34690.1; -; Genomic_DNA.
DR EMBL; KC489780; AGG19363.1; -; Genomic_DNA.
DR EMBL; KC489781; AGG19368.1; -; Genomic_DNA.
DR EMBL; KC489782; AGG19373.1; -; Genomic_DNA.
DR EMBL; KC489783; AGG19378.1; -; Genomic_DNA.
DR EMBL; KC489784; AGG19383.1; -; Genomic_DNA.
DR EMBL; KC489785; AGG19388.1; -; Genomic_DNA.
DR EMBL; KC489786; AGG19393.1; -; Genomic_DNA.
DR EMBL; KC489788; AGG19406.1; -; Genomic_DNA.
DR EMBL; KC489789; AGG19412.1; -; Genomic_DNA.
DR EMBL; KF823968; AHH83932.1; -; Genomic_DNA.
DR EMBL; KF823969; AHH83939.1; -; Genomic_DNA.
DR EMBL; KR066794; AKJ75210.1; -; Genomic_DNA.
DR EMBL; HE963029; CCJ27776.1; -; Genomic_DNA.
DR RefSeq; WP_002382874.1; NZ_QUXH01000003.1.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR CDD; cd12185; HGDH_LDH_like; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR InterPro; IPR029753; D-isomer_DH_CS.
DR InterPro; IPR029752; D-isomer_DH_CS1.
DR InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43026; 2-HYDROXYACID DEHYDROGENASE HOMOLOG 1-RELATED; 1.
DR PANTHER; PTHR43026:SF1; 2-HYDROXYACID DEHYDROGENASE HOMOLOG 1-RELATED; 1.
DR Pfam; PF00389; 2-Hacid_dh; 1.
DR Pfam; PF02826; 2-Hacid_dh_C; 1.
DR SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00065; D_2_HYDROXYACID_DH_1; 1.
DR PROSITE; PS00670; D_2_HYDROXYACID_DH_2; 1.
DR PROSITE; PS00671; D_2_HYDROXYACID_DH_3; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU003719}; Plasmid {ECO:0000313|EMBL:AKJ75210.1}.
FT DOMAIN 36..317
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase
FT catalytic"
FT /evidence="ECO:0000259|Pfam:PF00389"
FT DOMAIN 113..295
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase NAD-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02826"
SQ SEQUENCE 323 AA; 35173 MW; 4017495CA35B7606 CRC64;
MRKSVGITVF GCEQDEANAF RALSPDFHII PTLISDAISA DNAKLAAGNQ CVSVGHKSEV
SEATILALRK VGVKYISTRS IGCDHIDTTA AERMGISVGT VAYSPDSVAD YALMLMLMAI
RGAKPTMHAV AQQDFRLDRI RGKELGDMTV GVIGTGHIGQ AVVKRLRGFG CHVLAYDNSR
KMDADYVQLD ELLKNSDIVT LHVPLCADTR HLIGQKQIGE MKQGAFLINT GRGALVDTGA
LVEALESGKL GGAALDVLEG EDQFVYTDCS QKVLDHPFLS QLLRMPNVII TPHTAYYTER
VLQDTTEKTI RNCLNFERSL QHE
//
