ID Q9F245_AGGAC Unreviewed; 923 AA.
AC Q9F245;
DT 01-MAR-2001, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2001, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=Type IV secretion system protein virB4 {ECO:0000256|ARBA:ARBA00023635};
GN Name=magB03 {ECO:0000313|EMBL:AAG24434.1};
OS Aggregatibacter actinomycetemcomitans (Actinobacillus
OS actinomycetemcomitans) (Haemophilus actinomycetemcomitans).
OG Plasmid pVT745 {ECO:0000313|EMBL:AAG24434.1}.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Aggregatibacter.
OX NCBI_TaxID=714 {ECO:0000313|EMBL:AAG24434.1};
RN [1] {ECO:0000313|EMBL:AAG24434.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=VT745 {ECO:0000313|EMBL:AAG24434.1};
RC PLASMID=pVT745 {ECO:0000313|EMBL:AAG24434.1};
RX PubMed=11160089; DOI=10.1128/JB.183.5.1585-1594.2001;
RA Galli D.M., Chen J., Novak K.F., Leblanc D.J.;
RT "Nucleotide sequence and analysis of conjugative plasmid pVT745.";
RL J. Bacteriol. 183:1585-1594(2001).
CC -!- SIMILARITY: Belongs to the TrbE/VirB4 family.
CC {ECO:0000256|ARBA:ARBA00006512}.
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DR EMBL; AF302424; AAG24434.1; -; Genomic_DNA.
DR RefSeq; NP_067581.1; NC_002579.1.
DR RefSeq; WP_010901939.1; NC_002579.1.
DR AlphaFoldDB; Q9F245; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR Gene3D; 1.10.8.730; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR004346; CagE_TrbE_VirB.
DR InterPro; IPR018145; CagE_TrbE_VirB_cntrl_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR043964; P-loop_TraG.
DR InterPro; IPR007792; T4SS_VirB3/TrbD/AvhB.
DR NCBIfam; TIGR00929; VirB4_CagE; 1.
DR PANTHER; PTHR30121:SF10; BLR3062 PROTEIN; 1.
DR PANTHER; PTHR30121; UNCHARACTERIZED PROTEIN YJGR-RELATED; 1.
DR Pfam; PF03135; CagE_TrbE_VirB; 1.
DR Pfam; PF19044; P-loop_TraG; 1.
DR Pfam; PF05101; VirB3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Plasmid {ECO:0000313|EMBL:AAG24434.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Virulence {ECO:0000256|ARBA:ARBA00023026}.
FT TRANSMEM 22..43
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 285..487
FT /note="CagE TrbE VirB component of type IV transporter
FT system central"
FT /evidence="ECO:0000259|Pfam:PF03135"
FT DOMAIN 551..855
FT /note="TraG P-loop"
FT /evidence="ECO:0000259|Pfam:PF19044"
SQ SEQUENCE 923 AA; 104496 MW; 840A12BA28DDB314 CRC64;
MQADSENTIS GEPLFKGMIT QATISGIPIP IIFVIAFLSG LAYFISGKLY AVLPAIPLLI
GTRLLYETDR DFLTLNMLNF KTNSGLGKIV RFFGSKTFTA QKYNRTAFSE NRIETLGIKL
SEQKDYSKFI PYSSHIAPNV VITRNGDLVA TWCCKGVTFE TAENYELNLS KEKLNTLIQS
FSKKGVSFYQ HNIRHKVNET LDGHFSSEFT QEVNDKYYAG FNNGTLQRNI LYITLVYTPY
SKLEKISRKT TKLKDKKQEL AYQLETMQEM CSRLDKALED FRGEALTTFS KGGALYSEQL
SFYNYLITNR WQPVRVTSTS FYHLLGNTDL HFGKETGQIT FNGESRFFRC LEIKDYTEET
CEGFFDALMY INADYVITQS FQAMPSNVAK EKLDRQQKRL NSSNEAAISQ VDNLTVALDD
LASGRLSFGY YHFGMMVYGD SIKDVTDKTN EIIAVLSSLG LIITLANTAL SASYFGQFPA
NFAYRPRLAM LSSRNYASLT SLHNFASGKC NGNPWGDAVT LVKTPNAQPY YFNFHQSAPG
VDDRGEKRLG NTAVFGQAGS GKTMLMTFLM TQLDKFRHTS TFLPTSVKRE LTMVYLDKDY
GAEACIRAMG GKYMLIRKGV PTGFNPFMCE NTPENLSFLS TLMKMLVTRN GRTLSSLDEE
ELFKAVKSVM EFDMEYRSYP ISRVVEHLPE GSTKAEKENS LARRLKNWAQ GGEFGWVFDN
PADTLDFTGH AVFGIDGTEF LDDQDTCSPL SFYLLHRIGK LLDGRRLIIF MDEFWKWLKD
EAFSDFAYNK LKVIRKEDGI VIPMTQSMDE VLKSPISRAV VEECETTICL PNPIARKVDY
VDGFGISEKQ FEIIRELQPD SRTFLVRKGL ETALAKLDLS GLGRENLKIL STSKDNAEIL
HQIIEEVGEA ANDWIPIYKQ RCV
//
