ID   Q9FB26_9ACTO            Unreviewed;      1066 AA.
AC   Q9FB26;
DT   01-MAR-2001, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2001, sequence version 1.
DT   03-APR-2013, entry version 55.
DE   SubName: Full=Peptide synthetase NRPS7;
GN   Name=blmIX;
OS   Streptomyces verticillus.
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Streptomycineae; Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=29309;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ATCC15003;
RX   PubMed=11048953; DOI=10.1016/S1074-5521(00)00011-9;
RA   Du L., Sanchez C., Chen M., Edwards D.J., Shen B.;
RT   "The biosynthetic gene cluster for the antitumor drug bleomycin from
RT   Streptomyces verticillus ATCC15003 supporting functional interactions
RT   between nonribosomal peptide synthetases and a polyketide synthase.";
RL   Chem. Biol. 7:623-642(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ATCC15003;
RX   PubMed=10930733; DOI=10.1111/j.1574-6968.2000.tb09225.x;
RA   Du L., Chen M., Sanchez C., Shen B.;
RT   "An oxidation domain in the BlmIII non-ribosomal peptide synthetase
RT   probably catalyzing thiazole formation in the biosynthesis of the
RT   anti-tumor drug bleomycin in Streptomyces verticillus ATCC15003.";
RL   FEMS Microbiol. Lett. 189:171-175(2000).
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DR   EMBL; AF210249; AAG02356.1; -; Genomic_DNA.
DR   HSSP; P14687; 1AMU.
DR   ProteinModelPortal; Q9FB26; -.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   Gene3D; 1.10.1200.10; -; 1.
DR   InterPro; IPR010071; AA_adenyl_domain.
DR   InterPro; IPR009081; Acyl_carrier_prot-like.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig.
DR   InterPro; IPR001242; Condensatn.
DR   Pfam; PF00501; AMP-binding; 1.
DR   Pfam; PF00668; Condensation; 1.
DR   Pfam; PF00550; PP-binding; 1.
DR   SUPFAM; SSF47336; ACP_like; 1.
DR   TIGRFAMs; TIGR01733; AA-adenyl-dom; 1.
DR   PROSITE; PS50075; ACP_DOMAIN; 1.
DR   PROSITE; PS00455; AMP_BINDING; 1.
PE   4: Predicted;
SQ   SEQUENCE   1066 AA;  112814 MW;  A1A60F10403B670B CRC64;
     MTPAADTTHP LSPAQRSMWF LHRLAPEVPA YNICTAIELT GTPRPAALRD VVRRLGRRHE
     ALRTVFPSVG ETPRQRVTDR AAPLRTVDLT HLTPAAAEAE TARTLRCAAA RPFRLDTGPL
     AEWTLLRRAP GHALLVLSVH HIVFDGGSLH VVCRELEEAY GAALAGRPDP LGTPAPGYGR
     QCRTRAAEQD EAGREFWRRE LSGAPPRTTV FRGTGRPAGP PARATVHYGT DDPAPTADFC
     REHAVTGYVL LLAALACLVA RYTGRTDVVI GSPVGLREDP EGLATVGPML NLLPLRLRLH
     GDPGFGEVLA RTRETLLGAL EHRTTPFEDI VDAVGADRDP DVSPLFQILF AHERPPAPPA
     LPGVRARVVP VPAPAAKYEL AVTATETPDG LRLIVEAEHG HGEPAELAAF ARHFGVLLAA
     GVRAPDTPLS RLPLLTDEER RRLTDTTAPR TAPEAPYRPL HRLVEESAAR RPDALAVVGG
     TRHLSYRELN CRANRRAAWL RRAGIGTEDV VGVRLERGPE LLVSLLAVLK AGAAYLPVDP
     ALPAERVRLM LDDARAALLL TETALGTPPA PAGTPVHHVD GPPPPTRPGD DADHTGPDLP
     TSLAYLLYTS GSTGRPKAVA LQHDSAAAFL RWAGRAFDGG ELAAVLATTS AGFDLSVFEL
     FAPLAHGGTV VLADSALHVP ALPWAPAATL LNTVPSAAAA LLDADGLPDG LTAVNLAGEP
     LTAELVARLH ARLPKAAVRN LYGPSEATTY ATAALVPAGG TEAPAIGRAL GAARVWTADD
     RQRPLPGAVV GELLIGGTAP ARGYLGRPGP TADAFRPDPT GPPGSRLYRT GDLAVRRPDG
     RFVFLGRKDE QIKLRGVRIE PGEVEAALRQ CAPVAAAAVV LAGTTAENHR LVGFVTPSPG
     ARVDPERTLA ALRSRLPAAL VPAALVVCDA LPLTANGKTD RAALARRARG HRPDHGAYAP
     PRTRVEKAVA AIWREVLGTE RVGIHQGFFD AGGTSLSLLR LHHRLVASVH PGLRLADVFR
     LPTVAALAAF VDGQEDARET AVGDAALRAG RRRAAVAARR RKGGGR
//