GenomeNet

Database: UniProt
Entry: Q9FSC7_POPTR
LinkDB: Q9FSC7_POPTR
Original site: Q9FSC7_POPTR 
ID   Q9FSC7_POPTR            Unreviewed;       357 AA.
AC   Q9FSC7;
DT   01-MAR-2001, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2001, sequence version 1.
DT   24-JAN-2024, entry version 148.
DE   RecName: Full=cinnamyl-alcohol dehydrogenase {ECO:0000256|ARBA:ARBA00013171};
DE            EC=1.1.1.195 {ECO:0000256|ARBA:ARBA00013171};
GN   Name=cad {ECO:0000313|EMBL:CAC07423.1};
GN   ORFNames=POPTR_009G095800 {ECO:0000313|EMBL:PNT20512.1};
OS   Populus trichocarpa (Western balsam poplar) (Populus balsamifera subsp.
OS   trichocarpa).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Malpighiales; Salicaceae; Saliceae; Populus.
OX   NCBI_TaxID=3694 {ECO:0000313|EMBL:CAC07423.1};
RN   [1] {ECO:0000313|EMBL:CAC07423.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Leaves {ECO:0000313|EMBL:CAC07423.1};
RA   Van Doorsselaere J., Leple J.C., Boerjan W.;
RT   "Nucleotide sequence and promoter comparisons of two monolignol
RT   biosynthesis genes from poplar.";
RL   Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:PNT20512.1, ECO:0000313|Proteomes:UP000006729}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nisqually {ECO:0000313|Proteomes:UP000006729}, and
RC   Nisqually-1 {ECO:0000313|EMBL:PNT20512.1};
RX   PubMed=16973872; DOI=10.1126/science.1128691;
RA   Tuskan G.A., Difazio S., Jansson S., Bohlmann J., Grigoriev I.,
RA   Hellsten U., Putnam N., Ralph S., Rombauts S., Salamov A., Schein J.,
RA   Sterck L., Aerts A., Bhalerao R.R., Bhalerao R.P., Blaudez D., Boerjan W.,
RA   Brun A., Brunner A., Busov V., Campbell M., Carlson J., Chalot M.,
RA   Chapman J., Chen G.L., Cooper D., Coutinho P.M., Couturier J., Covert S.,
RA   Cronk Q., Cunningham R., Davis J., Degroeve S., Dejardin A.,
RA   Depamphilis C., Detter J., Dirks B., Dubchak I., Duplessis S., Ehlting J.,
RA   Ellis B., Gendler K., Goodstein D., Gribskov M., Grimwood J., Groover A.,
RA   Gunter L., Hamberger B., Heinze B., Helariutta Y., Henrissat B.,
RA   Holligan D., Holt R., Huang W., Islam-Faridi N., Jones S.,
RA   Jones-Rhoades M., Jorgensen R., Joshi C., Kangasjarvi J., Karlsson J.,
RA   Kelleher C., Kirkpatrick R., Kirst M., Kohler A., Kalluri U., Larimer F.,
RA   Leebens-Mack J., Leple J.C., Locascio P., Lou Y., Lucas S., Martin F.,
RA   Montanini B., Napoli C., Nelson D.R., Nelson C., Nieminen K., Nilsson O.,
RA   Pereda V., Peter G., Philippe R., Pilate G., Poliakov A., Razumovskaya J.,
RA   Richardson P., Rinaldi C., Ritland K., Rouze P., Ryaboy D., Schmutz J.,
RA   Schrader J., Segerman B., Shin H., Siddiqui A., Sterky F., Terry A.,
RA   Tsai C.J., Uberbacher E., Unneberg P., Vahala J., Wall K., Wessler S.,
RA   Yang G., Yin T., Douglas C., Marra M., Sandberg G., Van de Peer Y.,
RA   Rokhsar D.;
RT   "The genome of black cottonwood, Populus trichocarpa (Torr. & Gray).";
RL   Science 313:1596-1604(2006).
RN   [3] {ECO:0000313|EMBL:ACC63875.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=CAD1 {ECO:0000313|EMBL:ACC63875.1};
RX   PubMed=19996151; DOI=10.1093/pcp/pcp175;
RA   Shi R., Sun Y.H., Li Q., Heber S., Sederoff R., Chiang V.L.;
RT   "Towards a systems approach for lignin biosynthesis in Populus trichocarpa:
RT   transcript abundance and specificity of the monolignol biosynthetic
RT   genes.";
RL   Plant Cell Physiol. 51:144-163(2010).
RN   [4] {ECO:0000313|EMBL:PNT20512.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Nisqually-1 {ECO:0000313|EMBL:PNT20512.1};
RA   Tuskan G., Difazio S., Jansson S., Bohlmann J., Grigoriev I., Hellsten U.,
RA   Putnam N., Ralph S., Rombauts S., Salamov A., Schein J., Sterck L.,
RA   Aerts A., Bhalerao R., Bhalerao R., Blaudez D., Boerjan W., Brun A.,
RA   Brunner A., Busov V., Campbell M., Carlson J., Chalot M., Chapman J.,
RA   Chen G., Cooper D., Coutinho P., Couturier J., Covert S., Cronk Q.,
RA   Cunningham R., Davis J., Degroeve S., Dejardin A., Depamphilis C.,
RA   Detter J., Dirks B., Dubchak I., Duplessis S., Ehlting J., Ellis B.,
RA   Gendler K., Goodstein D., Gribskov M., Grimwood J., Groover A., Gunter L.,
RA   Hamberger B., Heinze B., Helariutta Y., Henrissat B., Holligan D., Holt R.,
RA   Huang W., Islam-Faridi N., Jones S., Jones-Rhoades M., Jorgensen R.,
RA   Joshi C., Kangasjarvi J., Karlsson J., Kelleher C., Kirkpatrick R.,
RA   Kirst M., Kohler A., Kalluri U., Larimer F., Leebens-Mack J., Leple J.,
RA   Locascio P., Lou Y., Lucas S., Martin F., Montanini B., Napoli C.,
RA   Nelson D., Nelson C., Nieminen K., Nilsson O., Pereda V., Peter G.,
RA   Philippe R., Pilate G., Poliakov A., Razumovskaya J., Richardson P.,
RA   Rinaldi C., Ritland K., Rouze P., Ryaboy D., Schmutz J., Schrader J.,
RA   Segerman B., Shin H., Siddiqui A., Sterky F., Terry A., Tsai C.,
RA   Uberbacher E., Unneberg P., Vahala J., Wall K., Wessler S., Yang G.,
RA   Yin T., Douglas C., Marra M., Sandberg G., Van De Peer Y., Rokhsar D.;
RT   "WGS assembly of Populus trichocarpa.";
RL   Submitted (JUL-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(E)-4-coumaroyl alcohol + NADP(+) = (E)-4-coumaraldehyde +
CC         H(+) + NADPH; Xref=Rhea:RHEA:45724, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:28353, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349,
CC         ChEBI:CHEBI:64555; EC=1.1.1.195;
CC         Evidence={ECO:0000256|ARBA:ARBA00036200};
CC       PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:45726;
CC         Evidence={ECO:0000256|ARBA:ARBA00036200};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(E)-cinnamyl alcohol + NADP(+) = (E)-cinnamaldehyde + H(+) +
CC         NADPH; Xref=Rhea:RHEA:10392, ChEBI:CHEBI:15378, ChEBI:CHEBI:16731,
CC         ChEBI:CHEBI:33227, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349;
CC         EC=1.1.1.195; Evidence={ECO:0000256|ARBA:ARBA00036166};
CC       PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:10394;
CC         Evidence={ECO:0000256|ARBA:ARBA00036166};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(E)-coniferol + NADP(+) = (E)-coniferaldehyde + H(+) + NADPH;
CC         Xref=Rhea:RHEA:22444, ChEBI:CHEBI:15378, ChEBI:CHEBI:16547,
CC         ChEBI:CHEBI:17745, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349;
CC         EC=1.1.1.195; Evidence={ECO:0000256|ARBA:ARBA00036509};
CC       PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:22446;
CC         Evidence={ECO:0000256|ARBA:ARBA00036509};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(E)-sinapyl alcohol + NADP(+) = (E)-sinapaldehyde + H(+) +
CC         NADPH; Xref=Rhea:RHEA:45704, ChEBI:CHEBI:15378, ChEBI:CHEBI:27949,
CC         ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:64557;
CC         EC=1.1.1.195; Evidence={ECO:0000256|ARBA:ARBA00035824};
CC       PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:45706;
CC         Evidence={ECO:0000256|ARBA:ARBA00035824};
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947,
CC         ECO:0000256|RuleBase:RU361277};
CC   -!- PATHWAY: Aromatic compound metabolism; phenylpropanoid biosynthesis.
CC       {ECO:0000256|ARBA:ARBA00004928}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC   -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC       family. {ECO:0000256|ARBA:ARBA00008072, ECO:0000256|RuleBase:RU361277}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; EU603306; ACC63875.1; -; mRNA.
DR   EMBL; AJ295837; CAC07423.1; -; Genomic_DNA.
DR   EMBL; CM009298; PNT20512.1; -; Genomic_DNA.
DR   RefSeq; XP_002313875.1; XM_002313839.2.
DR   AlphaFoldDB; Q9FSC7; -.
DR   STRING; 3694.Q9FSC7; -.
DR   EnsemblPlants; Potri.009G095800.1.v4.1; Potri.009G095800.1.v4.1; Potri.009G095800.v4.1.
DR   GeneID; 7490064; -.
DR   Gramene; Potri.009G095800.1.v4.1; Potri.009G095800.1.v4.1; Potri.009G095800.v4.1.
DR   KEGG; pop:7490064; -.
DR   eggNOG; KOG0023; Eukaryota.
DR   HOGENOM; CLU_026673_20_2_1; -.
DR   InParanoid; Q9FSC7; -.
DR   OMA; IVDQKFV; -.
DR   OrthoDB; 1550at2759; -.
DR   Proteomes; UP000006729; Chromosome 9.
DR   ExpressionAtlas; Q9FSC7; baseline and differential.
DR   GO; GO:0045551; F:cinnamyl-alcohol dehydrogenase activity; IBA:GO_Central.
DR   GO; GO:0052747; F:sinapyl alcohol dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0009809; P:lignin biosynthetic process; IBA:GO_Central.
DR   CDD; cd05283; CAD1; 1.
DR   Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR013149; ADH-like_C.
DR   InterPro; IPR013154; ADH-like_N.
DR   InterPro; IPR002328; ADH_Zn_CS.
DR   InterPro; IPR047109; CAD-like.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020843; PKS_ER.
DR   PANTHER; PTHR42683; ALDEHYDE REDUCTASE; 1.
DR   PANTHER; PTHR42683:SF1; CINNAMYL ALCOHOL DEHYDROGENASE 5; 1.
DR   Pfam; PF08240; ADH_N; 1.
DR   Pfam; PF00107; ADH_zinc_N; 1.
DR   SMART; SM00829; PKS_ER; 1.
DR   SUPFAM; SSF50129; GroES-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS00059; ADH_ZINC; 1.
PE   2: Evidence at transcript level;
KW   Metal-binding {ECO:0000256|RuleBase:RU361277};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000313|EMBL:CAC07423.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006729};
KW   Zinc {ECO:0000256|RuleBase:RU361277}.
FT   DOMAIN          15..348
FT                   /note="Enoyl reductase (ER)"
FT                   /evidence="ECO:0000259|SMART:SM00829"
SQ   SEQUENCE   357 AA;  38958 MW;  3300D89C133F0B71 CRC64;
     MGSLETERKI VGWAATDSTG HLAPYTYSLR DTGPEDVFIK VISCGVCHTD IHQIKNDLGM
     SHYPMVPGHE VVGEVVEVGS DVTKFKVGDV VGVGVIVGSC KNCHPCKSEI EQYCNKKIWS
     YNDVYTDGKP TQGGFAESMV VDQKFVVRIP DGMSPEQAAP LLCAGLTVYS PLKHFGLKQS
     GLRGGILGLG GVGHMGVKIA KAMGHHVTVI SSSDKKREEA MEHLGADEYL VSSDVESMQK
     AADQLDYIID TVPVVHPLEP YLSLLKLDGK LILMGVINAP LQFVTPMVML GRKSITGSFI
     GSMKETEEML EFCKEKGLAS MIEVIKMDYI NTAFERLEKN DVRYRFVVDV AGSKLIP
//
DBGET integrated database retrieval system