ID Q9GJS4_MACSY Unreviewed; 203 AA.
AC Q9GJS4;
DT 01-MAR-2001, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2001, sequence version 1.
DT 24-JAN-2024, entry version 101.
DE RecName: Full=Sex-determining region Y protein {ECO:0000256|ARBA:ARBA00019052};
DE AltName: Full=Testis-determining factor {ECO:0000256|ARBA:ARBA00032498};
DE Flags: Fragment;
GN Name=SRY {ECO:0000313|EMBL:AAG34435.1};
OS Macaca sylvanus (Barbary macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9546 {ECO:0000313|EMBL:AAG34435.1};
RN [1] {ECO:0000313|EMBL:AAG34435.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=11083929; DOI=10.1006/mpev.2000.0834;
RA Tosi A.J., Morales J.C., Melnick D.J.;
RT "Comparison of Y chromosome and mtDNA phylogenies leads to unique
RT inferences of macaque evolutionary history.";
RL Mol. Phylogenet. Evol. 17:133-144(2000).
RN [2] {ECO:0000313|EMBL:AAG34435.1}
RP NUCLEOTIDE SEQUENCE.
RA Tosi A.J., Morales J.C., Melnick D.J.;
RL Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:AAL78274.1}
RP NUCLEOTIDE SEQUENCE.
RA Tosi A.J., Morales J.C., Melnick D.J.;
RT "Y-Chromosome and Mitochondrial Markers in Macaca fascicularis Indicate
RT Introgression with Indochinese Macaca mulatta and a Biogeographic Barrier
RT in the Isthmus of Kra.";
RL Int. J. Primatol. 23:161-178(2002).
RN [4] {ECO:0000313|EMBL:ADX95830.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=21435245; DOI=10.1186/1471-2148-11-77;
RA Roos C., Zinner D., Kubatko L.S., Schwarz C., Yang M., Meyer D., Nash S.D.,
RA Xing J., Batzer M.A., Brameier M., Leendertz F.H., Ziegler T.,
RA Perwitasari-Farajallah D., Nadler T., Walter L., Osterholz M.;
RT "Nuclear versus Mitochondrial DNA: Evidence for Hybridization in Colobine
RT Monkeys.";
RL BMC Evol. Biol. 11:77-77(2011).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus speckle {ECO:0000256|ARBA:ARBA00004324}.
CC -!- SIMILARITY: Belongs to the SRY family. {ECO:0000256|ARBA:ARBA00005998}.
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DR EMBL; AF284325; AAG34434.1; -; Genomic_DNA.
DR EMBL; AF284326; AAG34435.1; -; Genomic_DNA.
DR EMBL; AF425296; AAL78274.1; -; Genomic_DNA.
DR EMBL; JF293179; ADX95830.1; -; Genomic_DNA.
DR AlphaFoldDB; Q9GJS4; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0030238; P:male sex determination; IEA:InterPro.
DR GO; GO:0007548; P:sex differentiation; IEA:UniProtKB-KW.
DR CDD; cd22034; HMG-box_SoxA_SRY; 1.
DR Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR017253; SRY.
DR PANTHER; PTHR10270:SF199; SEX-DETERMINING REGION Y PROTEIN; 1.
DR PANTHER; PTHR10270; SOX TRANSCRIPTION FACTOR; 1.
DR Pfam; PF00505; HMG_box; 1.
DR PIRSF; PIRSF037653; SRY; 1.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47095; HMG-box; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00267}; Nucleus {ECO:0000256|PROSITE-ProRule:PRU00267};
KW Sexual differentiation {ECO:0000256|ARBA:ARBA00022928};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 60..128
FT /note="HMG box"
FT /evidence="ECO:0000259|PROSITE:PS50118"
FT DNA_BIND 60..128
FT /note="HMG box"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT REGION 174..203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 180..196
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 203
FT /evidence="ECO:0000313|EMBL:AAG34435.1"
SQ SEQUENCE 203 AA; 23623 MW; A4BDAA4F9339B7E3 CRC64;
MQSYASAMLS VFNTDGYSPA AQQNIPALRR SSSFICTESC SSKYQCEAGE NSKGSVQDRV
KRPMNAFIVW SRDQRRKMAL ENPKMRNSEI SKQLGYQWKM LTEADKWPFF QEAQKLQAMH
REKYPNYKYR PRRKAKMLQN SCSLLPVDPS SVPCREVYNN RLYRDDCTKA THSRMQHQLG
HLPPINTASS PQQRDRYSHS TKL
//
