ID Q9GKB9_MACAS Unreviewed; 203 AA.
AC Q9GKB9;
DT 01-MAR-2001, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2001, sequence version 1.
DT 24-JAN-2024, entry version 100.
DE RecName: Full=Sex-determining region Y protein {ECO:0000256|ARBA:ARBA00019052};
DE AltName: Full=Testis-determining factor {ECO:0000256|ARBA:ARBA00032498};
DE Flags: Fragment;
GN Name=SRY {ECO:0000313|EMBL:AAG34404.1};
OS Macaca assamensis (Assam macaque) (Assamese macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9551 {ECO:0000313|EMBL:AAG34404.1};
RN [1] {ECO:0000313|EMBL:AAG34404.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=11083929; DOI=10.1006/mpev.2000.0834;
RA Tosi A.J., Morales J.C., Melnick D.J.;
RT "Comparison of Y chromosome and mtDNA phylogenies leads to unique
RT inferences of macaque evolutionary history.";
RL Mol. Phylogenet. Evol. 17:133-144(2000).
RN [2] {ECO:0000313|EMBL:AAG34404.1}
RP NUCLEOTIDE SEQUENCE.
RA Tosi A.J., Morales J.C., Melnick D.J.;
RL Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:AAP59464.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12894949;
RA Tosi A.J., Morales J.C., Melnick D.J.;
RT "Paternal, maternal, and biparental molecular markers provide unique
RT windows onto the evolutionary history of macaque monkeys.";
RL Evolution 57:1419-1435(2003).
RN [4] {ECO:0000313|EMBL:ANW35641.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=27135608;
RA Jiang J., Yu J., Li J., Li P., Fan Z., Niu L., Deng J., Yue B., Li J.;
RT "Mitochondrial Genome and Nuclear Markers Provide New Insight into the
RT Evolutionary History of Macaques.";
RL PLoS ONE 11:E0154665-E0154665(2016).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus speckle {ECO:0000256|ARBA:ARBA00004324}.
CC -!- SIMILARITY: Belongs to the SRY family. {ECO:0000256|ARBA:ARBA00005998}.
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DR EMBL; AF284295; AAG34404.1; -; Genomic_DNA.
DR EMBL; AY224238; AAP59464.1; -; Genomic_DNA.
DR EMBL; KT356226; ANW35641.1; -; Genomic_DNA.
DR AlphaFoldDB; Q9GKB9; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0030238; P:male sex determination; IEA:InterPro.
DR GO; GO:0007548; P:sex differentiation; IEA:UniProtKB-KW.
DR CDD; cd22034; HMG-box_SoxA_SRY; 1.
DR Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR017253; SRY.
DR PANTHER; PTHR10270:SF199; SEX-DETERMINING REGION Y PROTEIN; 1.
DR PANTHER; PTHR10270; SOX TRANSCRIPTION FACTOR; 1.
DR Pfam; PF00505; HMG_box; 1.
DR PIRSF; PIRSF037653; SRY; 1.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47095; HMG-box; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00267}; Nucleus {ECO:0000256|PROSITE-ProRule:PRU00267};
KW Sexual differentiation {ECO:0000256|ARBA:ARBA00022928};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 60..128
FT /note="HMG box"
FT /evidence="ECO:0000259|PROSITE:PS50118"
FT DNA_BIND 60..128
FT /note="HMG box"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT REGION 174..203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 180..196
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 203
FT /evidence="ECO:0000313|EMBL:AAG34404.1"
SQ SEQUENCE 203 AA; 23565 MW; 02A11A499539BB44 CRC64;
MQSYASAMLS VFNTDGYSPA AQQNIPALRR SSSFICAESC SSKYQCEAGE NSKGSVQDRV
KRPMNAFIVW SRDQRRKMAL ENPKMRNSEI SKQLGYQWKM LTEADKWPFF QEAQKLQAMH
REKYPNYKYR PRRKAKMLQN SCSLLPADPS SVPCREVYNN RLYRDDCTKA THSRMQHQLG
HLPPINTASS PQQRDRYSHS TKL
//
