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Database: UniProt
Entry: Q9GL43
LinkDB: Q9GL43
Original site: Q9GL43 
ID   HFE_DICBI               Reviewed;         348 AA.
AC   Q9GL43; Q9GK81;
DT   25-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   01-OCT-2014, entry version 58.
DE   RecName: Full=Hereditary hemochromatosis protein homolog;
DE   Flags: Precursor;
GN   Name=HFE;
OS   Diceros bicornis (Black rhinoceros).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Rhinocerotidae;
OC   Diceros.
OX   NCBI_TaxID=9805;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RA   West C.J., Worley M., Beutler E.;
RT   "Rhinoceros HFE polymorphisms.";
RL   Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Binds to transferrin receptor (TFR) and reduces its
CC       affinity for iron-loaded transferrin.
CC   -!- SUBUNIT: Binds TFR through the extracellular domain.
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane
CC       protein.
CC   -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}.
CC   -!- SIMILARITY: Contains 1 Ig-like C1-type (immunoglobulin-like)
CC       domain. {ECO:0000305}.
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DR   EMBL; AY007542; AAG23702.1; -; mRNA.
DR   EMBL; AF301592; AAG39940.1; -; Genomic_DNA.
DR   ProteinModelPortal; Q9GL43; -.
DR   SMR; Q9GL43; 26-297.
DR   HOVERGEN; HBG016709; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW.
DR   GO; GO:0042605; F:peptide antigen binding; IEA:InterPro.
DR   GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0001916; P:positive regulation of T cell mediated cytotoxicity; IEA:InterPro.
DR   Gene3D; 2.60.40.10; -; 1.
DR   Gene3D; 3.30.500.10; -; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003006; Ig/MHC_CS.
DR   InterPro; IPR003597; Ig_C1-set.
DR   InterPro; IPR011161; MHC_I-like_Ag-recog.
DR   InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR   InterPro; IPR027648; MHC_I_a.
DR   InterPro; IPR001039; MHC_I_a_a1/a2.
DR   Pfam; PF07654; C1-set; 1.
DR   Pfam; PF00129; MHC_I; 1.
DR   PRINTS; PR01638; MHCCLASSI.
DR   SMART; SM00407; IGc1; 1.
DR   SUPFAM; SSF54452; SSF54452; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS00290; IG_MHC; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Immunity; Membrane; MHC I; Signal;
KW   Transmembrane; Transmembrane helix.
FT   SIGNAL        1     22       {ECO:0000250}.
FT   CHAIN        23    348       Hereditary hemochromatosis protein
FT                                homolog.
FT                                /FTId=PRO_0000018890.
FT   TOPO_DOM     23    306       Extracellular. {ECO:0000255}.
FT   TRANSMEM    307    330       Helical. {ECO:0000255}.
FT   TOPO_DOM    331    348       Cytoplasmic. {ECO:0000255}.
FT   DOMAIN      207    296       Ig-like C1-type.
FT   REGION       23    114       Alpha-1.
FT   REGION      115    205       Alpha-2.
FT   REGION      206    297       Alpha-3.
FT   REGION      298    306       Connecting peptide.
FT   CARBOHYD    110    110       N-linked (GlcNAc...). {ECO:0000255}.
FT   CARBOHYD    130    130       N-linked (GlcNAc...). {ECO:0000255}.
FT   CARBOHYD    234    234       N-linked (GlcNAc...). {ECO:0000255}.
FT   DISULFID    124    187       {ECO:0000255|PROSITE-ProRule:PRU00114}.
FT   DISULFID    225    282       {ECO:0000255|PROSITE-ProRule:PRU00114}.
SQ   SEQUENCE   348 AA;  39818 MW;  4D95E7B01E48FB90 CRC64;
     MGPRARPALF FLILLRTVAA QGRPPRSHSL RYLFMGASER DHGLPLFEAL GYVDDELFVA
     YNHESRRAES RAQWVLGEAH SQLWLQLTQS LKGWDHMFIV DFWTIMDNHN HSKESHTLQV
     ILGCEVQEDN STRGFWKYGY DGQDHLEFCP ETLDWRAAES RALTTKLEWE VNKIRAKQNR
     AYLERDCPEQ LQWLLELGRG VLDQQVPPLV KVTHHVASAV TTLRCQALNF YPQNITMRWL
     KDRKPVDVKD AESKDVLPSG DGTYQSWEAL AVPPGEEQRY TCQVEHPGLD QPLTATWEPS
     LSNTLVTGVI SGIAVCVIIF FIGILFRILR KRQASRGAMG DYVLAECE
//
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