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Database: UniProt
Entry: Q9GZX6
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Original site: Q9GZX6 
ID   IL22_HUMAN              Reviewed;         179 AA.
AC   Q9GZX6;
DT   16-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   16-APR-2014, entry version 129.
DE   RecName: Full=Interleukin-22;
DE            Short=IL-22;
DE   AltName: Full=Cytokine Zcyto18;
DE   AltName: Full=IL-10-related T-cell-derived-inducible factor;
DE            Short=IL-TIF;
DE   Flags: Precursor;
GN   Name=IL22; Synonyms=ILTIF, ZCYTO18; ORFNames=UNQ3099/PRO10096;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=10954742; DOI=10.1073/pnas.170291697;
RA   Dumoutier L., Van Roost E., Colau D., Renauld J.-C.;
RT   "Human interleukin-10-related T cell-derived inducible factor:
RT   molecular cloning and functional characterization as an hepatocyte-
RT   stimulating factor.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:10144-10149(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11197690; DOI=10.1038/sj.gene.6363716;
RA   Dumoutier L., Van Roost E., Colau D., Ameye G., Michaux L.,
RA   Renauld J.-C.;
RT   "IL-TIF/IL-22: genomic organization and mapping of the human and mouse
RT   genes.";
RL   Genes Immun. 1:488-494(2000).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=10875937; DOI=10.1074/jbc.M005304200;
RA   Xie M.-H., Aggarwal S., Ho W.-H., Foster J., Zhang Z., Stinson J.,
RA   Wood W.I., Goddard A.D., Gurney A.L.;
RT   "Interleukin (IL)-22, a novel human cytokine that signals through the
RT   interferon receptor-related proteins CRF2-4 and IL-22R.";
RL   J. Biol. Chem. 275:31335-31339(2000).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
RA   Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
RA   Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
RA   Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
RA   Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
RA   Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
RA   Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale
RT   effort to identify novel human secreted and transmembrane proteins: a
RT   bioinformatics assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT GLY-158.
RG   SeattleSNPs variation discovery resource;
RL   Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Blood;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [7]
RP   PROTEIN SEQUENCE OF 34-48.
RX   PubMed=15340161; DOI=10.1110/ps.04682504;
RA   Zhang Z., Henzel W.J.;
RT   "Signal peptide prediction based on analysis of experimentally
RT   verified cleavage sites.";
RL   Protein Sci. 13:2819-2824(2004).
RN   [8]
RP   X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 29-179.
RX   PubMed=11856845; DOI=10.1107/S0907444902001063;
RA   Nagem R.A., Lucchesi K.W., Colau D., Dumoutier L., Renauld J.-C.,
RA   Polikarpov I.;
RT   "Crystallization and synchrotron X-ray diffraction studies of human
RT   interleukin-22.";
RL   Acta Crystallogr. D 58:529-530(2002).
RN   [9]
RP   X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 38-179, AND GLYCOSYLATION AT
RP   ASN-54 AND ASN-97.
RX   PubMed=15983417; DOI=10.1107/S0907444905009601;
RA   Xu T., Logsdon N.J., Walter M.R.;
RT   "Structure of insect-cell-derived IL-22.";
RL   Acta Crystallogr. D 61:942-950(2005).
RN   [10]
RP   X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 39-179 IN COMPLEX WITH
RP   IL22RA1, AND DISULFIDE BONDS.
RX   PubMed=18599299; DOI=10.1016/j.str.2008.06.005;
RA   Jones B.C., Logsdon N.J., Walter M.R.;
RT   "Structure of IL-22 bound to its high-affinity IL-22R1 chain.";
RL   Structure 16:1333-1344(2008).
CC   -!- FUNCTION: Cytokine that contributes to the inflammatory response
CC       in vivo.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the IL-10 family.
CC   -!- WEB RESOURCE: Name=SeattleSNPs;
CC       URL="http://pga.gs.washington.edu/data/il22/";
CC   -!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology
CC       and Haematology;
CC       URL="http://atlasgeneticsoncology.org/Genes/IL22ID44519ch12q15.html";
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DR   EMBL; AJ277247; CAC06085.1; -; mRNA.
DR   EMBL; AJ277248; CAC19409.1; -; Genomic_DNA.
DR   EMBL; AF279437; AAG22064.1; -; mRNA.
DR   EMBL; AY358890; AAQ89249.1; -; mRNA.
DR   EMBL; AF387519; AAK62468.1; -; Genomic_DNA.
DR   EMBL; BC066263; AAH66263.1; -; mRNA.
DR   EMBL; BC067510; AAH67510.1; -; mRNA.
DR   EMBL; BC069112; AAH69112.1; -; mRNA.
DR   EMBL; BC069308; AAH69308.1; -; mRNA.
DR   EMBL; BC070261; AAH70261.1; -; mRNA.
DR   RefSeq; NP_065386.1; NM_020525.4.
DR   RefSeq; XP_005268986.1; XM_005268929.1.
DR   UniGene; Hs.287369; -.
DR   PDB; 1M4R; X-ray; 2.00 A; A/B=29-179.
DR   PDB; 1YKB; X-ray; 2.60 A; A/B/C/D/E/F=38-179.
DR   PDB; 3DGC; X-ray; 2.50 A; L/M=39-179.
DR   PDB; 3DLQ; X-ray; 1.90 A; I=29-179.
DR   PDB; 3G9V; X-ray; 2.76 A; B/D=29-179.
DR   PDB; 3Q1S; X-ray; 2.15 A; I=29-179.
DR   PDBsum; 1M4R; -.
DR   PDBsum; 1YKB; -.
DR   PDBsum; 3DGC; -.
DR   PDBsum; 3DLQ; -.
DR   PDBsum; 3G9V; -.
DR   PDBsum; 3Q1S; -.
DR   ProteinModelPortal; Q9GZX6; -.
DR   SMR; Q9GZX6; 38-179.
DR   BioGrid; 119096; 3.
DR   DIP; DIP-46035N; -.
DR   IntAct; Q9GZX6; 2.
DR   MINT; MINT-6693924; -.
DR   STRING; 9606.ENSP00000329384; -.
DR   DMDM; 17366814; -.
DR   PaxDb; Q9GZX6; -.
DR   PRIDE; Q9GZX6; -.
DR   DNASU; 50616; -.
DR   Ensembl; ENST00000328087; ENSP00000329384; ENSG00000127318.
DR   Ensembl; ENST00000538666; ENSP00000442424; ENSG00000127318.
DR   GeneID; 50616; -.
DR   KEGG; hsa:50616; -.
DR   UCSC; uc001sty.1; human.
DR   CTD; 50616; -.
DR   GeneCards; GC12M068642; -.
DR   HGNC; HGNC:14900; IL22.
DR   MIM; 605330; gene.
DR   neXtProt; NX_Q9GZX6; -.
DR   PharmGKB; PA29822; -.
DR   eggNOG; NOG42949; -.
DR   HOGENOM; HOG000280686; -.
DR   HOVERGEN; HBG018572; -.
DR   InParanoid; Q9GZX6; -.
DR   KO; K05445; -.
DR   OMA; IEGDDQH; -.
DR   OrthoDB; EOG7J9VR1; -.
DR   PhylomeDB; Q9GZX6; -.
DR   TreeFam; TF333253; -.
DR   SignaLink; Q9GZX6; -.
DR   EvolutionaryTrace; Q9GZX6; -.
DR   GeneWiki; Interleukin_22; -.
DR   GenomeRNAi; 50616; -.
DR   NextBio; 53128; -.
DR   PRO; PR:Q9GZX6; -.
DR   Bgee; Q9GZX6; -.
DR   CleanEx; HS_IL22; -.
DR   Genevestigator; Q9GZX6; -.
DR   GO; GO:0005576; C:extracellular region; IC:UniProtKB.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0045518; F:interleukin-22 receptor binding; NAS:UniProtKB.
DR   GO; GO:0006953; P:acute-phase response; NAS:UniProtKB.
DR   GO; GO:0007267; P:cell-cell signaling; IC:UniProtKB.
DR   GO; GO:0006954; P:inflammatory response; NAS:UniProtKB.
DR   GO; GO:0051384; P:response to glucocorticoid; IEA:Ensembl.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR012351; 4_helix_cytokine_core.
DR   InterPro; IPR020423; IL-10_CS.
DR   InterPro; IPR020453; IL-22.
DR   PIRSF; PIRSF037726; Interleukin-22; 1.
DR   PRINTS; PR01936; INTRLEUKIN22.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00520; INTERLEUKIN_10; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Complete proteome; Cytokine; Direct protein sequencing;
KW   Disulfide bond; Glycoprotein; Polymorphism; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL        1     33
FT   CHAIN        34    179       Interleukin-22.
FT                                /FTId=PRO_0000015383.
FT   CARBOHYD     54     54       N-linked (GlcNAc...).
FT   CARBOHYD     68     68       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD     97     97       N-linked (GlcNAc...).
FT   DISULFID     40    132
FT   DISULFID     89    178
FT   VARIANT     158    158       S -> G (in dbSNP:rs2227507).
FT                                /FTId=VAR_013078.
FT   HELIX        44     47
FT   HELIX        50     65
FT   STRAND       74     76
FT   HELIX        77     80
FT   HELIX        85     87
FT   HELIX        88    102
FT   TURN        103    109
FT   HELIX       114    129
FT   HELIX       141    155
FT   HELIX       157    165
FT   HELIX       167    178
SQ   SEQUENCE   179 AA;  20011 MW;  3C35E64D60CF8767 CRC64;
     MAALQKSVSS FLMGTLATSC LLLLALLVQG GAAAPISSHC RLDKSNFQQP YITNRTFMLA
     KEASLADNNT DVRLIGEKLF HGVSMSERCY LMKQVLNFTL EEVLFPQSDR FQPYMQEVVP
     FLARLSNRLS TCHIEGDDLH IQRNVQKLKD TVKKLGESGE IKAIGELDLL FMSLRNACI
//
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