ID WDR76_HUMAN Reviewed; 626 AA.
AC Q9H967; A0MNP5; Q05CI4;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 30-NOV-2010, sequence version 2.
DT 27-MAR-2024, entry version 170.
DE RecName: Full=WD repeat-containing protein 76;
GN Name=WDR76;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH CUL4A AND/OR CUL4B, AND
RP VARIANT ALA-153.
RX PubMed=17041588; DOI=10.1038/ncb1490;
RA Higa L.A., Wu M., Ye T., Kobayashi R., Sun H., Zhang H.;
RT "CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins
RT and regulates histone methylation.";
RL Nat. Cell Biol. 8:1277-1283(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ALA-153.
RC TISSUE=Teratocarcinoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16572171; DOI=10.1038/nature04601;
RA Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J.,
RA Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E.,
RA Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B.,
RA Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R.,
RA O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B.,
RA Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S.,
RA Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.;
RT "Analysis of the DNA sequence and duplication history of human chromosome
RT 15.";
RL Nature 440:671-675(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ALA-153.
RC TISSUE=Eye, and Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting
CC that it acts as a specific reader of 5hmC. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with CUL4A and/or CUL4B.
CC {ECO:0000269|PubMed:17041588}.
CC -!- SIMILARITY: Belongs to the WD repeat DDB2/WDR76 family. {ECO:0000305}.
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DR EMBL; EF011624; ABK41114.1; -; mRNA.
DR EMBL; AK023035; BAB14369.1; -; mRNA.
DR EMBL; AK290933; BAF83622.1; -; mRNA.
DR EMBL; AC018512; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC023356; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC025247; AAH25247.1; -; mRNA.
DR EMBL; BC051855; AAH51855.1; -; mRNA.
DR CCDS; CCDS10106.1; -.
DR RefSeq; NP_001161413.1; NM_001167941.1.
DR RefSeq; NP_079184.2; NM_024908.3.
DR RefSeq; XP_005254737.1; XM_005254680.3.
DR AlphaFoldDB; Q9H967; -.
DR SMR; Q9H967; -.
DR BioGRID; 123035; 386.
DR IntAct; Q9H967; 27.
DR MINT; Q9H967; -.
DR STRING; 9606.ENSP00000263795; -.
DR iPTMnet; Q9H967; -.
DR PhosphoSitePlus; Q9H967; -.
DR BioMuta; WDR76; -.
DR DMDM; 313104049; -.
DR EPD; Q9H967; -.
DR jPOST; Q9H967; -.
DR MassIVE; Q9H967; -.
DR MaxQB; Q9H967; -.
DR PaxDb; 9606-ENSP00000263795; -.
DR PeptideAtlas; Q9H967; -.
DR ProteomicsDB; 81286; -.
DR Pumba; Q9H967; -.
DR Antibodypedia; 52296; 82 antibodies from 22 providers.
DR DNASU; 79968; -.
DR Ensembl; ENST00000263795.11; ENSP00000263795.6; ENSG00000092470.12.
DR GeneID; 79968; -.
DR KEGG; hsa:79968; -.
DR MANE-Select; ENST00000263795.11; ENSP00000263795.6; NM_024908.4; NP_079184.2.
DR UCSC; uc001zti.3; human.
DR AGR; HGNC:25773; -.
DR CTD; 79968; -.
DR DisGeNET; 79968; -.
DR GeneCards; WDR76; -.
DR HGNC; HGNC:25773; WDR76.
DR HPA; ENSG00000092470; Tissue enhanced (bone marrow, lymphoid tissue).
DR MIM; 620302; gene.
DR neXtProt; NX_Q9H967; -.
DR OpenTargets; ENSG00000092470; -.
DR PharmGKB; PA142670580; -.
DR VEuPathDB; HostDB:ENSG00000092470; -.
DR eggNOG; KOG4328; Eukaryota.
DR GeneTree; ENSGT00510000048144; -.
DR InParanoid; Q9H967; -.
DR OMA; DTVVRHN; -.
DR OrthoDB; 3679036at2759; -.
DR PhylomeDB; Q9H967; -.
DR TreeFam; TF314788; -.
DR PathwayCommons; Q9H967; -.
DR SignaLink; Q9H967; -.
DR BioGRID-ORCS; 79968; 13 hits in 1162 CRISPR screens.
DR ChiTaRS; WDR76; human.
DR GenomeRNAi; 79968; -.
DR Pharos; Q9H967; Tbio.
DR PRO; PR:Q9H967; -.
DR Proteomes; UP000005640; Chromosome 15.
DR RNAct; Q9H967; Protein.
DR Bgee; ENSG00000092470; Expressed in oocyte and 120 other cell types or tissues.
DR ExpressionAtlas; Q9H967; baseline and differential.
DR Genevisible; Q9H967; HS.
DR GO; GO:0000792; C:heterochromatin; IMP:UniProtKB.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0090734; C:site of DNA damage; IMP:UniProtKB.
DR GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR GO; GO:0019899; F:enzyme binding; IPI:UniProtKB.
DR GO; GO:0006974; P:DNA damage response; IMP:UniProtKB.
DR GO; GO:2000001; P:regulation of DNA damage checkpoint; IBA:GO_Central.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR14773; UNCHARACTERIZED; 1.
DR PANTHER; PTHR14773:SF0; WD REPEAT-CONTAINING PROTEIN 76; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
PE 1: Evidence at protein level;
KW Reference proteome; Repeat; WD repeat.
FT CHAIN 1..626
FT /note="WD repeat-containing protein 76"
FT /id="PRO_0000242691"
FT REPEAT 311..352
FT /note="WD 1"
FT REPEAT 358..400
FT /note="WD 2"
FT REPEAT 402..441
FT /note="WD 3"
FT REPEAT 446..485
FT /note="WD 4"
FT REPEAT 493..533
FT /note="WD 5"
FT REPEAT 535..565
FT /note="WD 6"
FT REPEAT 590..626
FT /note="WD 7"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 95..159
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 100..140
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 153
FT /note="S -> A (in dbSNP:rs678084)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:17041588"
FT /id="VAR_026862"
FT VARIANT 614
FT /note="S -> G (in dbSNP:rs3742985)"
FT /id="VAR_026863"
SQ SEQUENCE 626 AA; 69769 MW; DC6DE3A59250EFA1 CRC64;
MSRSGAAAEK ADSRQRPQMK VNEYKENQNI AYVSLRPAQT TVLIKTAKVY LAPFSLSNYQ
LDQLMCPKSL SEKNSNNEVA CKKTKIKKTC RRIIPPKMKN TSSKAESTLQ NSSSAVHTES
NKLQPKRTAD AMNLSVDVES SQDGDSDEDT TPSLDFSGLS PYERKRLKNI SENADFFASL
QLSESAARLR EMIEKRQPPK SKRKKPKREN GIGCRRSMRL LKVDPSGVSL PAAPTPPTLV
ADETPLLPPG PLEMTSENQE DNNERFKGFL HTWAGMSKPS SKNTEKGLSS IKSYKANLNG
MVISEDTVYK VTTGPIFSMA LHPSETRTLV AVGAKFGQVG LCDLTQQPKE DGVYVFHPHS
QPVSCLYFSP ANPAHILSLS YDGTLRCGDF SRAIFEEVYR NERSSFSSFD FLAEDASTLI
VGHWDGNMSL VDRRTPGTSY EKLTSSSMGK IRTVHVHPVH RQYFITAGLR DTHIYDARRL
NSRRSQPLIS LTEHTKSIAS AYFSPLTGNR VVTTCADCNL RIFDSSCISS KIPLLTTIRH
NTFTGRWLTR FQAMWDPKQE DCVIVGSMAH PRRVEIFHET GKRVHSFGGE YLVSVCSINA
MHPTRYILAG GNSSGKIHVF MNEKSC
//
