ID CP4FB_HUMAN Reviewed; 524 AA.
AC Q9HBI6; O75254; Q96AQ5;
DT 10-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 3.
DT 01-MAY-2013, entry version 115.
DE RecName: Full=Cytochrome P450 4F11;
DE EC=1.14.14.1;
DE AltName: Full=CYPIVF11;
GN Name=CYP4F11;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND VARIANT ARG-276.
RC TISSUE=Brain, and Liver;
RX PubMed=10964514; DOI=10.1006/geno.2000.6276;
RA Cui X., Nelson D.R., Strobel H.W.;
RT "A novel human cytochrome P450 4F isoform (CYP4F11): cDNA cloning,
RT expression, and genomic structural characterization.";
RL Genomics 68:161-166(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ARG-276.
RC TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- CATALYTIC ACTIVITY: RH + reduced flavoprotein + O(2) = ROH +
CC oxidized flavoprotein + H(2)O.
CC -!- COFACTOR: Heme group (By similarity).
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass
CC membrane protein (By similarity). Microsome membrane; Single-pass
CC membrane protein (By similarity).
CC -!- TISSUE SPECIFICITY: Expressed mainly in human liver, followed by
CC kidney, heart, and skeletal muscle.
CC -!- SIMILARITY: Belongs to the cytochrome P450 family.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC27731.1; Type=Erroneous gene model prediction;
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DR EMBL; AF236085; AAG15889.1; -; mRNA.
DR EMBL; AC005336; AAC27731.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AC020950; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC011517; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC016853; AAH16853.1; -; mRNA.
DR IPI; IPI00307483; -.
DR RefSeq; NP_001122404.1; NM_001128932.1.
DR RefSeq; NP_067010.3; NM_021187.3.
DR UniGene; Hs.187393; -.
DR ProteinModelPortal; Q9HBI6; -.
DR SMR; Q9HBI6; 97-510.
DR IntAct; Q9HBI6; 1.
DR STRING; 9606.ENSP00000248041; -.
DR PhosphoSite; Q9HBI6; -.
DR DMDM; 296439388; -.
DR PaxDb; Q9HBI6; -.
DR PRIDE; Q9HBI6; -.
DR DNASU; 57834; -.
DR Ensembl; ENST00000248041; ENSP00000248041; ENSG00000171903.
DR Ensembl; ENST00000402119; ENSP00000384588; ENSG00000171903.
DR GeneID; 57834; -.
DR KEGG; hsa:57834; -.
DR UCSC; uc002nbt.2; human.
DR CTD; 57834; -.
DR GeneCards; GC19M016023; -.
DR H-InvDB; HIX0014857; -.
DR HGNC; HGNC:13265; CYP4F11.
DR HPA; HPA017265; -.
DR MIM; 611517; gene.
DR neXtProt; NX_Q9HBI6; -.
DR PharmGKB; PA27120; -.
DR eggNOG; COG2124; -.
DR HOGENOM; HOG000233833; -.
DR HOVERGEN; HBG000182; -.
DR InParanoid; Q9HBI6; -.
DR KO; K00490; -.
DR OMA; EPLGANS; -.
DR OrthoDB; EOG4Q58P4; -.
DR PhylomeDB; Q9HBI6; -.
DR Reactome; REACT_111217; Metabolism.
DR GenomeRNAi; 57834; -.
DR NextBio; 64827; -.
DR ArrayExpress; Q9HBI6; -.
DR Bgee; Q9HBI6; -.
DR CleanEx; HS_CYP4F11; -.
DR Genevestigator; Q9HBI6; -.
DR GermOnline; ENSG00000171903; Homo sapiens.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0070330; F:aromatase activity; IEA:EC.
DR GO; GO:0009055; F:electron carrier activity; IEA:InterPro.
DR GO; GO:0020037; F:heme binding; TAS:UniProtKB.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0004497; F:monooxygenase activity; NAS:UniProtKB.
DR GO; GO:0006954; P:inflammatory response; TAS:UniProtKB.
DR GO; GO:0044281; P:small molecule metabolic process; TAS:Reactome.
DR GO; GO:0006805; P:xenobiotic metabolic process; TAS:Reactome.
DR Gene3D; 1.10.630.10; -; 1.
DR InterPro; IPR001128; Cyt_P450.
DR InterPro; IPR017972; Cyt_P450_CS.
DR InterPro; IPR002401; Cyt_P450_E_grp-I.
DR Pfam; PF00067; p450; 1.
DR PRINTS; PR00463; EP450I.
DR PRINTS; PR00385; P450.
DR SUPFAM; SSF48264; Cytochrome_P450; 1.
DR PROSITE; PS00086; CYTOCHROME_P450; 1.
PE 2: Evidence at transcript level;
KW Complete proteome; Endoplasmic reticulum; Heme; Iron; Membrane;
KW Metal-binding; Microsome; Monooxygenase; Oxidoreductase; Polymorphism;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1 524 Cytochrome P450 4F11.
FT /FTId=PRO_0000051856.
FT TRANSMEM 15 37 Helical; (Potential).
FT METAL 468 468 Iron (heme axial ligand) (By similarity).
FT BINDING 328 328 Heme (covalent; via 1 link) (By
FT similarity).
FT VARIANT 146 146 R -> C (in dbSNP:rs57519667).
FT /FTId=VAR_060265.
FT VARIANT 276 276 C -> R (in dbSNP:rs8104361).
FT /FTId=VAR_060266.
FT VARIANT 284 284 D -> N (in dbSNP:rs1060463).
FT /FTId=VAR_060267.
FT CONFLICT 446 446 D -> N (in Ref. 1; AAG15889 and 3;
FT AAH16853).
FT CONFLICT 496 496 T -> I (in Ref. 1; AAG15889).
SQ SEQUENCE 524 AA; 60146 MW; 8B0F14C52E657CB2 CRC64;
MPQLSLSWLG LGPVAASPWL LLLLVGGSWL LARVLAWTYT FYDNCRRLQC FPQPPKQNWF
WGHQGLVTPT EEGMKTLTQL VTTYPQGFKL WLGPTFPLLI LCHPDIIRPI TSASAAVAPK
DMIFYGFLKP WLGDGLLLSG GDKWSRHRRM LTPAFHFNIL KPYMKIFNKS VNIMHDKWQR
LASEGSARLD MFEHISLMTL DSLQKCVFSF ESNCQEKPSE YIAAILELSA FVEKRNQQIL
LHTDFLYYLT PDGQRFRRAC HLVHDFTDAV IQERRCTLPT QGIDDFLKNK AKSKTLDFID
VLLLSKDEDG KELSDEDIRA EADTFMFEGH DTTASGLSWV LYHLAKHPEY QEQCRQEVQE
LLKDREPIEI EWDDLAQLPF LTMCIKESLR LHPPVPVISR CCTQDFVLPD GRVIPKGIVC
LINIIGIHYN PTVWPDPEVY DPFRFDQENI KERSPLAFIP FSAGPRNCIG QAFAMAEMKV
VLALTLLHFR ILPTHTEPRR KPELILRAEG GLWLRVEPLG ANSQ
//
