ID Q9HER7_PARBR Unreviewed; 416 AA.
AC Q9HER7;
DT 01-MAR-2001, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2001, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE RecName: Full=glucan 1,3-beta-glucosidase {ECO:0000256|ARBA:ARBA00038929};
DE EC=3.2.1.58 {ECO:0000256|ARBA:ARBA00038929};
GN Name=gp43 {ECO:0000313|EMBL:AAG36681.1};
OS Paracoccidioides brasiliensis.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenales incertae sedis; Paracoccidioides.
OX NCBI_TaxID=121759 {ECO:0000313|EMBL:AAG36681.1};
RN [1] {ECO:0000313|EMBL:AAG36681.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Mg5 {ECO:0000313|EMBL:AAG36681.1};
RX PubMed=11060052;
RA Morais F.V., Barros T.F., Fukada M.K., Cisalpino P.S., Puccia R.;
RT "Polymorphism in the gene coding for the immunodominant antigen gp43 from
RT the pathogenic fungus Paracoccidioides brasiliensis.";
RL J. Clin. Microbiol. 38:3960-3966(2000).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Successive hydrolysis of beta-D-glucose units from the non-
CC reducing ends of (1->3)-beta-D-glucans, releasing alpha-glucose.;
CC EC=3.2.1.58; Evidence={ECO:0000256|ARBA:ARBA00036824};
CC -!- SUBUNIT: Monomer. {ECO:0000256|ARBA:ARBA00011245}.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 5 (cellulase A) family.
CC {ECO:0000256|ARBA:ARBA00005641, ECO:0000256|RuleBase:RU361153}.
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DR EMBL; AY005419; AAG36681.1; -; Genomic_DNA.
DR AlphaFoldDB; Q9HER7; -.
DR VEuPathDB; FungiDB:PADG_07615; -.
DR GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR GO; GO:0000272; P:polysaccharide catabolic process; IEA:UniProt.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR InterPro; IPR001547; Glyco_hydro_5.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR PANTHER; PTHR31297:SF1; GLUCAN 1,3-BETA-GLUCOSIDASE I_II-RELATED; 1.
DR PANTHER; PTHR31297; GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B; 1.
DR Pfam; PF00150; Cellulase; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
PE 3: Inferred from homology;
KW Cell wall biogenesis/degradation {ECO:0000256|ARBA:ARBA00023316};
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|RuleBase:RU361153};
KW Hydrolase {ECO:0000256|RuleBase:RU361153};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..416
FT /note="glucan 1,3-beta-glucosidase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004326738"
FT DOMAIN 86..246
FT /note="Glycoside hydrolase family 5"
FT /evidence="ECO:0000259|Pfam:PF00150"
SQ SEQUENCE 416 AA; 45850 MW; DA0380454731E1F4 CRC64;
MNFSSLNLAL ASCVLAWVCL ASASSHVASH IVPRQAGSAI YGVNIGGWLL LEPWISPSVL
EAGGSSSVDE YTLSKNLGRD AKGHLSKHWD TFITEDDFKN IAAAGLNHVR IPIGYWAVNP
IEGEPYVQGQ LDYLDKALVW AKNSNLRVVI DLHGVPGSQN GFDNSGHRGA VNWQKGDTIR
QTLIAIHTLA IRYANRTDVV DSIELVNKPS IPGGVQVSLL KEYYEDGYHI VRDIDSTVGV
SISDASLPPR TWNGFLAPKT YKNVYLDTYH NQVFDDIFRT FTIDQHVKLA CSLPHDRLRG
ADKPLIVKEW SGAMTDCAMY LNGRGIGSRF DGSFPSGKPS GACGARSKGS SSELSAQQKK
DTLRYIEAQL DAFEVGAGWY FWTWKTEGAP GWDMQDLLNQ KLFPQPIWAR KYGGCR
//
