ID Q9HGZ3_ASPOZ Unreviewed; 490 AA.
AC Q9HGZ3;
DT 01-MAR-2001, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2001, sequence version 1.
DT 24-JAN-2024, entry version 107.
DE RecName: Full=Phosphotransferase {ECO:0000256|RuleBase:RU362007};
DE EC=2.7.1.- {ECO:0000256|RuleBase:RU362007};
GN Name=hxkA {ECO:0000313|EMBL:BAB12228.1};
GN ORFNames=OAory_01108740 {ECO:0000313|EMBL:OOO04537.1};
OS Aspergillus oryzae (Yellow koji mold).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=5062 {ECO:0000313|EMBL:BAB12228.1};
RN [1] {ECO:0000313|EMBL:BAB12228.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=RIB40 {ECO:0000313|EMBL:BAB12228.1};
RA Nakajima K., Kunihiro S., Motoaki S., Eto S., Machida M.;
RT "Molecular cloning and characterization of glycolytic gene from Aspergillus
RT oryzae.";
RL Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:OOO04537.1, ECO:0000313|Proteomes:UP000190312}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BCC7051 {ECO:0000313|EMBL:OOO04537.1,
RC ECO:0000313|Proteomes:UP000190312};
RA Thammarongtham C., Vorapreeda T., Nookaew I., Srisuk T., Land M.,
RA Jeennor S., Laoteng K.;
RT "Genome sequencing of Aspergillus oryzae BCC7051.";
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + D-fructose = ADP + D-fructose 6-phosphate + H(+);
CC Xref=Rhea:RHEA:16125, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:37721, ChEBI:CHEBI:61527, ChEBI:CHEBI:456216; EC=2.7.1.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001397};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16126;
CC Evidence={ECO:0000256|ARBA:ARBA00001397};
CC -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-
CC phosphate and glycerone phosphate from D-glucose: step 1/4.
CC {ECO:0000256|ARBA:ARBA00004888}.
CC -!- PATHWAY: Carbohydrate metabolism; hexose metabolism.
CC {ECO:0000256|ARBA:ARBA00005028}.
CC -!- SIMILARITY: Belongs to the hexokinase family.
CC {ECO:0000256|ARBA:ARBA00009225, ECO:0000256|RuleBase:RU362007}.
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DR EMBL; AB032268; BAB12228.1; -; mRNA.
DR EMBL; MKZY01000010; OOO04537.1; -; Genomic_DNA.
DR AlphaFoldDB; Q9HGZ3; -.
DR VEuPathDB; FungiDB:AO090001000710; -.
DR eggNOG; KOG1369; Eukaryota.
DR OMA; ADCVQQF; -.
DR UniPathway; UPA00109; UER00180.
DR Proteomes; UP000190312; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0005536; F:glucose binding; IEA:InterPro.
DR GO; GO:0004396; F:hexokinase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0001678; P:intracellular glucose homeostasis; IEA:InterPro.
DR CDD; cd00012; NBD_sugar-kinase_HSP70_actin; 1.
DR Gene3D; 1.10.287.1250; -; 1.
DR Gene3D; 3.30.420.40; -; 1.
DR Gene3D; 3.40.367.20; -; 1.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR001312; Hexokinase.
DR InterPro; IPR019807; Hexokinase_BS.
DR InterPro; IPR022673; Hexokinase_C.
DR InterPro; IPR022672; Hexokinase_N.
DR PANTHER; PTHR19443; HEXOKINASE; 1.
DR PANTHER; PTHR19443:SF16; HEXOKINASE TYPE 1-RELATED; 1.
DR Pfam; PF00349; Hexokinase_1; 1.
DR Pfam; PF03727; Hexokinase_2; 1.
DR PRINTS; PR00475; HEXOKINASE.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 2.
DR PROSITE; PS00378; HEXOKINASE_1; 1.
DR PROSITE; PS51748; HEXOKINASE_2; 1.
PE 2: Evidence at transcript level;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU362007};
KW Glycolysis {ECO:0000256|ARBA:ARBA00023152, ECO:0000256|RuleBase:RU362007};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|RuleBase:RU362007};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU362007};
KW Reference proteome {ECO:0000313|Proteomes:UP000190312};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU362007}.
FT DOMAIN 27..221
FT /note="Hexokinase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00349"
FT DOMAIN 227..467
FT /note="Hexokinase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03727"
SQ SEQUENCE 490 AA; 54147 MW; 28B891A5E6E37FF1 CRC64;
MVGIGPKRPP SRKGSMHELP QNLLEQIKQF EDIFTVDGAK LKQIADHFVK ELEKGLSVEG
GNIPMNVTWV MGFPDGDEQG TFLALDMGGT NLRVCEITLT EEKGAFDITQ SKYRMPEELK
TGTAEELWEY IADCLQQFIE SHHENEKLSK LPLGFTFSYP ATQEYIDHGV LQRWTKGFDI
DGVEGQDVVP PLEAILKKRG LPIKVAALIN DTTGTLIASS YTDSDMKIGC IFGTGVNAAY
MEHCGSVPKL AHKNLPPDMP VAINCEYGAF DNEHVVLPLT KYDIIIDRDS PRPGQQAFEK
MTAGLYLGEI FRLALLDLLE TRPGLIFQGQ DTSQLRKPYL LDASFLAAIE DDPYENLQET
QELMERKLNI KATQQELEMI RRLAELIGTR AARLSACGVA AICKKKNIES CHVGADGSVF
TKYPHFKARG AQALREILDW APNEKDKVVI MAAEDGSGVG AALIAALTLK RVKAGISCGI
RDMADMQSLI
//
