ID Q9HHB2_9EURY Unreviewed; 327 AA.
AC Q9HHB2; Q7LX08;
DT 01-MAR-2001, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2001, sequence version 1.
DT 27-MAR-2024, entry version 113.
DE SubName: Full=Putative galactose-1-phosphate uridylyltransferase {ECO:0000313|EMBL:AAG28458.1};
GN Name=galT {ECO:0000313|EMBL:AAG28458.1};
OS Pyrococcus furiosus.
OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC Pyrococcus.
OX NCBI_TaxID=2261 {ECO:0000313|EMBL:AAG28458.1};
RN [1] {ECO:0000313|EMBL:AAG28458.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=DSM 3638 {ECO:0000313|EMBL:AAG28458.1};
RA Verhees C.H.;
RL Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|PIRSR:PIRSR000808-3};
CC Note=Binds 1 zinc ion per subunit. {ECO:0000256|PIRSR:PIRSR000808-3};
CC -!- SIMILARITY: Belongs to the galactose-1-phosphate uridylyltransferase
CC type 1 family. {ECO:0000256|ARBA:ARBA00010951}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00464}.
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DR EMBL; AF195244; AAG28458.1; -; Genomic_DNA.
DR RefSeq; WP_011011559.1; NC_018092.1.
DR AlphaFoldDB; Q9HHB2; -.
DR GeneID; 41712241; -.
DR OMA; CFENRGA; -.
DR UniPathway; UPA00214; -.
DR GO; GO:0008108; F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0033499; P:galactose catabolic process via UDP-galactose; IEA:InterPro.
DR CDD; cd00608; GalT; 1.
DR Gene3D; 3.30.428.10; HIT-like; 2.
DR InterPro; IPR001937; GalP_UDPtransf1.
DR InterPro; IPR005850; GalP_Utransf_C.
DR InterPro; IPR005849; GalP_Utransf_N.
DR InterPro; IPR011146; HIT-like.
DR InterPro; IPR036265; HIT-like_sf.
DR NCBIfam; TIGR00209; galT_1; 1.
DR PANTHER; PTHR11943; GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE; 1.
DR PANTHER; PTHR11943:SF1; GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE; 1.
DR Pfam; PF02744; GalP_UDP_tr_C; 1.
DR Pfam; PF01087; GalP_UDP_transf; 1.
DR PIRSF; PIRSF000808; GalT; 1.
DR SUPFAM; SSF54197; HIT-like; 2.
DR PROSITE; PS51084; HIT_2; 1.
PE 3: Inferred from homology;
KW Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023277};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR000808-3};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000313|EMBL:AAG28458.1};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:AAG28458.1};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PIRSR:PIRSR000808-3}.
FT DOMAIN 172..283
FT /note="HIT"
FT /evidence="ECO:0000259|PROSITE:PS51084"
FT ACT_SITE 141
FT /note="Tele-UMP-histidine intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000808-1"
FT BINDING 31
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PIRSR:PIRSR000808-3"
FT BINDING 34
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PIRSR:PIRSR000808-3"
FT BINDING 87
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PIRSR:PIRSR000808-3"
FT BINDING 139
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PIRSR:PIRSR000808-3"
SQ SEQUENCE 327 AA; 38482 MW; ECA9E4DF3B109AF3 CRC64;
MRELRYNPLT GQWIMVSAVR KKRPWRPTNF CPFCPGSEET GYGWKVLLLP NRFPMLSFDA
PKPESEEFYK KARAIGQCSV IVETPDHDLK DLDELPREQM VKVVELWVEA TKTLKENPHV
AYLAIFRNKG EEIGVSLTHP HGQLYALPYI PLKARLKIEN SRKYYKSKNE CLFCRILKEE
KESEERIIYE NDNFIVFMPF FASWPFEMHI YPKRHVQYLT DLNKEEIESL ADAIQATTGT
LNTILERQMP YTMMIFQAPF KGNYKFYHLH IEFYPILRDN GKIKYAAGIE MGTWEFTYDA
IPEENARKLK EACKKVSQRL NLKGKCI
//
