ID Q9HHM8_HALSA Unreviewed; 263 AA.
AC Q9HHM8;
DT 01-MAR-2001, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2001, sequence version 1.
DT 27-MAR-2024, entry version 122.
DE SubName: Full=Transcription regulator {ECO:0000313|EMBL:AAG20949.1, ECO:0000313|EMBL:DAC79914.1};
GN Name=arcR {ECO:0000313|EMBL:AAG20949.1};
GN OrderedLocusNames=VNG_6318G {ECO:0000313|EMBL:AAG20949.1};
OS Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)
OS (Halobacterium halobium).
OG Plasmid pNRC200 {ECO:0000313|EMBL:AAG20949.1,
OG ECO:0000313|Proteomes:UP000000554}.
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC Halobacteriaceae; Halobacterium; Halobacterium salinarum NRC-34001.
OX NCBI_TaxID=64091 {ECO:0000313|EMBL:AAG20949.1, ECO:0000313|Proteomes:UP000000554};
RN [1] {ECO:0000313|EMBL:AAG20949.1, ECO:0000313|Proteomes:UP000000554}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700922 / JCM 11081 / NRC-1
RC {ECO:0000313|Proteomes:UP000000554}, and NRC-1
RC {ECO:0000313|EMBL:AAG20949.1};
RC PLASMID=Plasmid pNRC200 {ECO:0000313|Proteomes:UP000000554};
RX PubMed=11016950; DOI=10.1073/pnas.190337797;
RA Ng W.V., Kennedy S.P., Mahairas G.G., Berquist B., Pan M., Shukla H.D.,
RA Lasky S.R., Baliga N.S., Thorsson V., Sbrogna J., Swartzell S., Weir D.,
RA Hall J., Dahl T.A., Welti R., Goo Y.A., Leithauser B., Keller K., Cruz R.,
RA Danson M.J., Hough D.W., Maddocks D.G., Jablonski P.E., Krebs M.P.,
RA Angevine C.M., Dale H., Isenbarger T.A., Peck R.F., Pohlschroder M.,
RA Spudich J.L., Jung K.W., Alam M., Freitas T., Hou S., Daniels C.J.,
RA Dennis P.P., Omer A.D., Ebhardt H., Lowe T.M., Liang P., Riley M., Hood L.,
RA DasSarma S.;
RT "Genome sequence of Halobacterium species NRC-1.";
RL Proc. Natl. Acad. Sci. U.S.A. 97:12176-12181(2000).
RN [2] {ECO:0000313|EMBL:DAC79914.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NRC-1 {ECO:0000313|EMBL:DAC79914.1};
RC PLASMID=pNRC200 {ECO:0000313|EMBL:DAC79914.1};
RX PubMed=18313895; DOI=.1016/j.ygeno.2008.01.001;
RA Pfeiffer F., Schuster S.C., Broicher A., Falb M., Palm P., Rodewald K.,
RA Ruepp A., Soppa J., Tittor J., Oesterhelt D.;
RT "Evolution in the laboratory: the genome of Halobacterium salinarum strain
RT R1 compared to that of strain NRC-1.";
RL Genomics 91:335-346(2008).
RN [3] {ECO:0000313|EMBL:DAC79914.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NRC-1 {ECO:0000313|EMBL:DAC79914.1};
RC PLASMID=pNRC200 {ECO:0000313|EMBL:DAC79914.1};
RX PubMed=26042526;
RA Pfeiffer F., Oesterhelt D.;
RT "A manual curation strategy to improve genome annotation: application to a
RT set of haloarchael genomes.";
RL Life 5:1427-1444(2015).
RN [4] {ECO:0000313|EMBL:DAC79914.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NRC-1 {ECO:0000313|EMBL:DAC79914.1};
RC PLASMID=pNRC200 {ECO:0000313|EMBL:DAC79914.1};
RA Pfeiffer F., Marchfelder A., Habermann B.H., Dyall-Smith M.;
RT "The genome of the Halobacterium salinarum type strain is closely related
RT to that of the laboratory strains NRC-1 and R1.";
RL Microbiol. Resour. Announc. 0:0-0(2019).
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DR EMBL; AE004438; AAG20949.1; -; Genomic_DNA.
DR EMBL; BK010831; DAC79914.1; -; Genomic_DNA.
DR RefSeq; WP_010904162.1; NZ_BK010831.1.
DR AlphaFoldDB; Q9HHM8; -.
DR SMR; Q9HHM8; -.
DR DNASU; 1449197; -.
DR GeneID; 68695253; -.
DR KEGG; hal:VNG_6318G; -.
DR PATRIC; fig|64091.14.peg.2295; -.
DR HOGENOM; CLU_062618_6_1_2; -.
DR OrthoDB; 14763at2157; -.
DR Proteomes; UP000000554; Plasmid pNRC200.
DR GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IBA:GO_Central.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR014757; Tscrpt_reg_IclR_C.
DR InterPro; IPR005471; Tscrpt_reg_IclR_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR30136; HELIX-TURN-HELIX TRANSCRIPTIONAL REGULATOR, ICLR FAMILY; 1.
DR PANTHER; PTHR30136:SF35; TRANSCRIPTIONAL REGULATORY PROTEIN; 1.
DR Pfam; PF09339; HTH_IclR; 1.
DR Pfam; PF01614; IclR; 1.
DR SMART; SM00346; HTH_ICLR; 1.
DR SUPFAM; SSF55781; GAF domain-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51077; HTH_ICLR; 1.
DR PROSITE; PS51078; ICLR_ED; 1.
PE 4: Predicted;
KW Plasmid {ECO:0000313|EMBL:AAG20949.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000554};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 14..74
FT /note="HTH iclR-type"
FT /evidence="ECO:0000259|PROSITE:PS51077"
FT DOMAIN 75..262
FT /note="IclR-ED"
FT /evidence="ECO:0000259|PROSITE:PS51078"
SQ SEQUENCE 263 AA; 29054 MW; 6F39239CC73B9E49 CRC64;
MDPEAANNGE PRRITSVLNA VEIIDAIKEH RGITLQELTT ELDLTKATIH TYMATLRQVG
IVEQDGDGTY QLGDWFVPVS NYARNSTDLY RLGREEIDKL ATQTRHTAHL VTESDGRQIV
LYESMGEESV TTEYHLRMRE TPRKLHTSAA GKSILAFLPE GRRETLISEI EFGTESSTPI
GSPDALREQL ATVRDQGYAI NDEEEIHGIR SIGAPIRGRT EDVAGAVSVT APKTRLQNAE
FAGEVPALVM EAANIIEVRL ETA
//
