ID Q9HQH4_HALSA Unreviewed; 315 AA.
AC Q9HQH4;
DT 01-MAR-2001, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2001, sequence version 1.
DT 27-MAR-2024, entry version 101.
DE SubName: Full=5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase (Methionine synthase II) {ECO:0000313|EMBL:DAC78255.1};
DE EC=2.1.1.14 {ECO:0000313|EMBL:DAC78255.1};
GN Name=metE {ECO:0000313|EMBL:DAC78255.1};
GN OrderedLocusNames=VNG_1162H {ECO:0000313|EMBL:AAG19541.1};
OS Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)
OS (Halobacterium halobium).
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC Halobacteriaceae; Halobacterium; Halobacterium salinarum NRC-34001.
OX NCBI_TaxID=64091 {ECO:0000313|EMBL:AAG19541.1, ECO:0000313|Proteomes:UP000000554};
RN [1] {ECO:0000313|EMBL:AAG19541.1, ECO:0000313|Proteomes:UP000000554}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700922 / JCM 11081 / NRC-1
RC {ECO:0000313|Proteomes:UP000000554}, and NRC-1
RC {ECO:0000313|EMBL:AAG19541.1};
RX PubMed=11016950; DOI=10.1073/pnas.190337797;
RA Ng W.V., Kennedy S.P., Mahairas G.G., Berquist B., Pan M., Shukla H.D.,
RA Lasky S.R., Baliga N.S., Thorsson V., Sbrogna J., Swartzell S., Weir D.,
RA Hall J., Dahl T.A., Welti R., Goo Y.A., Leithauser B., Keller K., Cruz R.,
RA Danson M.J., Hough D.W., Maddocks D.G., Jablonski P.E., Krebs M.P.,
RA Angevine C.M., Dale H., Isenbarger T.A., Peck R.F., Pohlschroder M.,
RA Spudich J.L., Jung K.W., Alam M., Freitas T., Hou S., Daniels C.J.,
RA Dennis P.P., Omer A.D., Ebhardt H., Lowe T.M., Liang P., Riley M., Hood L.,
RA DasSarma S.;
RT "Genome sequence of Halobacterium species NRC-1.";
RL Proc. Natl. Acad. Sci. U.S.A. 97:12176-12181(2000).
RN [2] {ECO:0000313|EMBL:DAC78255.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NRC-1 {ECO:0000313|EMBL:DAC78255.1};
RX PubMed=18313895; DOI=.1016/j.ygeno.2008.01.001;
RA Pfeiffer F., Schuster S.C., Broicher A., Falb M., Palm P., Rodewald K.,
RA Ruepp A., Soppa J., Tittor J., Oesterhelt D.;
RT "Evolution in the laboratory: the genome of Halobacterium salinarum strain
RT R1 compared to that of strain NRC-1.";
RL Genomics 91:335-346(2008).
RN [3] {ECO:0000313|EMBL:DAC78255.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NRC-1 {ECO:0000313|EMBL:DAC78255.1};
RX PubMed=26042526;
RA Pfeiffer F., Oesterhelt D.;
RT "A manual curation strategy to improve genome annotation: application to a
RT set of haloarchael genomes.";
RL Life 5:1427-1444(2015).
RN [4] {ECO:0000313|EMBL:DAC78255.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NRC-1 {ECO:0000313|EMBL:DAC78255.1};
RA Pfeiffer F., Marchfelder A., Habermann B.H., Dyall-Smith M.;
RT "The genome of the Halobacterium salinarum type strain is closely related
RT to that of the laboratory strains NRC-1 and R1.";
RL Microbiol. Resour. Announc. 0:0-0(2019).
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DR EMBL; AE004437; AAG19541.1; -; Genomic_DNA.
DR EMBL; BK010829; DAC78255.1; -; Genomic_DNA.
DR PIR; A84272; A84272.
DR RefSeq; WP_010902836.1; NC_002607.1.
DR AlphaFoldDB; Q9HQH4; -.
DR STRING; 64091.VNG_1162H; -.
DR PaxDb; 64091-VNG_1162H; -.
DR GeneID; 68693936; -.
DR KEGG; hal:VNG_1162H; -.
DR PATRIC; fig|64091.14.peg.888; -.
DR HOGENOM; CLU_881690_0_0_2; -.
DR OrthoDB; 33991at2157; -.
DR Proteomes; UP000000554; Chromosome.
DR GO; GO:0003871; F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0009086; P:methionine biosynthetic process; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR Gene3D; 3.20.20.210; -; 1.
DR InterPro; IPR002629; Met_Synth_C/arc.
DR InterPro; IPR038071; UROD/MetE-like_sf.
DR Pfam; PF01717; Meth_synt_2; 1.
DR SUPFAM; SSF51726; UROD/MetE-like; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000313|EMBL:DAC78255.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000554};
KW Transferase {ECO:0000313|EMBL:DAC78255.1}.
FT DOMAIN 38..307
FT /note="Cobalamin-independent methionine synthase MetE C-
FT terminal/archaeal"
FT /evidence="ECO:0000259|Pfam:PF01717"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 315 AA; 32273 MW; 7CF7884A4C9A887F CRC64;
MSRIATTPGL LPSPVAPDDG GGGPTPVVAA DSAVRDAHLA AQRDADLDRV VEGQAGWWDG
IVHPLVAHDN VARGPLAHST AVARGVYRRP VVAGPLTFDG GLGADLAAVA DRTASLQAVV
PGPYTLSTLA TDDHYGDPAE FQAAIAAFLA DELAALPDAV ATVFVLEPSL IAAPPGDGAD
ERASDAIDTV AAAVTDADVV VHTYGGALDE KVHAHLLDAA IDAVGYDLIA DHEDAAYLVG
EYGTADSIAL GVANARTPAV DAPATLRERV DWFDDRTPND FATVYTTTDS VLATLPQSRL
VAQLRALGAA TTPQS
//
