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Database: UniProt
Entry: Q9HRJ8
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ID   COXX_HALSA              Reviewed;         442 AA.
AC   Q9HRJ8;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   01-OCT-2014, entry version 74.
DE   RecName: Full=Protoheme IX farnesyltransferase;
DE            EC=2.5.1.-;
DE   AltName: Full=Heme B farnesyltransferase;
DE   AltName: Full=Heme O synthase;
GN   Name=ctaB; OrderedLocusNames=VNG_0666G;
OS   Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)
OS   (Halobacterium halobium).
OC   Archaea; Euryarchaeota; Halobacteria; Halobacteriales;
OC   Halobacteriaceae; Halobacterium.
OX   NCBI_TaxID=64091;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700922 / JCM 11081 / NRC-1;
RX   PubMed=11016950; DOI=10.1073/pnas.190337797;
RA   Ng W.V., Kennedy S.P., Mahairas G.G., Berquist B., Pan M.,
RA   Shukla H.D., Lasky S.R., Baliga N.S., Thorsson V., Sbrogna J.,
RA   Swartzell S., Weir D., Hall J., Dahl T.A., Welti R., Goo Y.A.,
RA   Leithauser B., Keller K., Cruz R., Danson M.J., Hough D.W.,
RA   Maddocks D.G., Jablonski P.E., Krebs M.P., Angevine C.M., Dale H.,
RA   Isenbarger T.A., Peck R.F., Pohlschroder M., Spudich J.L., Jung K.-H.,
RA   Alam M., Freitas T., Hou S., Daniels C.J., Dennis P.P., Omer A.D.,
RA   Ebhardt H., Lowe T.M., Liang P., Riley M., Hood L., DasSarma S.;
RT   "Genome sequence of Halobacterium species NRC-1.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:12176-12181(2000).
CC   -!- FUNCTION: Converts heme B (protoheme IX) to heme O by substitution
CC       of the vinyl group on carbon 2 of heme B porphyrin ring with a
CC       hydroxyethyl farnesyl side group. {ECO:0000250}.
CC   -!- PATHWAY: Porphyrin-containing compound metabolism; heme O
CC       biosynthesis; heme O from protoheme: step 1/1.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000305}.
CC   -!- MISCELLANEOUS: Carbon 2 of the heme B porphyrin ring is defined
CC       according to the Fischer nomenclature. {ECO:0000250}.
CC   -!- SIMILARITY: In the C-terminal section; belongs to the UbiA
CC       prenyltransferase family. Protoheme IX farnesyltransferase
CC       subfamily. {ECO:0000305}.
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DR   EMBL; AE004437; AAG19160.1; -; Genomic_DNA.
DR   PIR; D84224; D84224.
DR   RefSeq; NP_279680.1; NC_002607.1.
DR   STRING; 64091.VNG0666G; -.
DR   EnsemblBacteria; AAG19160; AAG19160; VNG_0666G.
DR   GeneID; 1447466; -.
DR   KEGG; hal:VNG0666G; -.
DR   eggNOG; COG1612; -.
DR   KO; K02301; -.
DR   OMA; SGTFNHV; -.
DR   UniPathway; UPA00834; UER00712.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016627; F:oxidoreductase activity, acting on the CH-CH group of donors; IEA:InterPro.
DR   GO; GO:0008495; F:protoheme IX farnesyltransferase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006784; P:heme a biosynthetic process; IEA:InterPro.
DR   GO; GO:0048034; P:heme O biosynthetic process; IEA:UniProtKB-HAMAP.
DR   HAMAP; MF_00154; CyoE_CtaB; 1.
DR   InterPro; IPR003780; COX15/CtaA_fam.
DR   InterPro; IPR006369; Protohaem_IX_farnesylTrfase.
DR   InterPro; IPR000537; UbiA_prenyltransferase.
DR   Pfam; PF02628; COX15-CtaA; 1.
DR   Pfam; PF01040; UbiA; 1.
DR   TIGRFAMs; TIGR01473; cyoE_ctaB; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Complete proteome; Heme biosynthesis; Membrane;
KW   Reference proteome; Transferase; Transmembrane; Transmembrane helix.
FT   CHAIN         1    442       Protoheme IX farnesyltransferase.
FT                                /FTId=PRO_0000327195.
FT   TRANSMEM     49     69       Helical. {ECO:0000255}.
FT   TRANSMEM     76     96       Helical. {ECO:0000255}.
FT   TRANSMEM    106    126       Helical. {ECO:0000255}.
FT   TRANSMEM    167    187       Helical. {ECO:0000255}.
FT   TRANSMEM    194    214       Helical. {ECO:0000255}.
FT   TRANSMEM    245    265       Helical. {ECO:0000255}.
FT   TRANSMEM    267    287       Helical. {ECO:0000255}.
FT   TRANSMEM    308    328       Helical. {ECO:0000255}.
FT   TRANSMEM    365    385       Helical. {ECO:0000255}.
FT   TRANSMEM    386    406       Helical. {ECO:0000255}.
FT   TRANSMEM    421    441       Helical. {ECO:0000255}.
FT   REGION        1    167       Unknown.
FT   REGION      168    439       Prenyltransferase.
SQ   SEQUENCE   442 AA;  46128 MW;  A951E2B87C9FFE30 CRC64;
     MGVYSLLVLG ATTSLTGAAS ACQTWPSCNG QWFALQSLDL VVVWGHRTAA ALTGLAVVGA
     AVLAWRTGAS RRVRTAVTLA LALYPVQVVI GAYTAMSAGA APFTGVHLTL GVGIFASLVV
     ALAWTLDAQT GDLPSAEWEG EPRHTDDGDP TQPGIVRAYV QLMKPRLMWL LCLVAGAGMA
     LASSQLGAGQ QLSAATVVLT LGGGVLSIGA SGTFNHVLER EQDEKMARTD DRPVVTDRIP
     PRNALAFGVV LGVASLAAFA AVNLLTAVLG LTAIAFYSIV YTLVLKPNTR QSTVIGGAAG
     ALPALIGWVA VTGAVGVGGV VLAGVIFLWT PAHFYNLALA YKDDYERGGF PLMPVVEGEA
     KTRRHIVYYI GATLASAVVL AELTGLGPLY AATTVLLGAV FLYFAIRLHR ERDRRAAMRS
     FHASNAYLGC LLVAVVLDTM VV
//
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