ID COXX_HALSA Reviewed; 442 AA.
AC Q9HRJ8;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 01-MAY-2013, entry version 68.
DE RecName: Full=Protoheme IX farnesyltransferase;
DE EC=2.5.1.-;
DE AltName: Full=Heme B farnesyltransferase;
DE AltName: Full=Heme O synthase;
GN Name=ctaB; OrderedLocusNames=VNG_0666G;
OS Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)
OS (Halobacterium halobium).
OC Archaea; Euryarchaeota; Halobacteria; Halobacteriales;
OC Halobacteriaceae; Halobacterium.
OX NCBI_TaxID=64091;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700922 / JCM 11081 / NRC-1;
RX PubMed=11016950; DOI=10.1073/pnas.190337797;
RA Ng W.V., Kennedy S.P., Mahairas G.G., Berquist B., Pan M.,
RA Shukla H.D., Lasky S.R., Baliga N.S., Thorsson V., Sbrogna J.,
RA Swartzell S., Weir D., Hall J., Dahl T.A., Welti R., Goo Y.A.,
RA Leithauser B., Keller K., Cruz R., Danson M.J., Hough D.W.,
RA Maddocks D.G., Jablonski P.E., Krebs M.P., Angevine C.M., Dale H.,
RA Isenbarger T.A., Peck R.F., Pohlschroder M., Spudich J.L., Jung K.-H.,
RA Alam M., Freitas T., Hou S., Daniels C.J., Dennis P.P., Omer A.D.,
RA Ebhardt H., Lowe T.M., Liang P., Riley M., Hood L., DasSarma S.;
RT "Genome sequence of Halobacterium species NRC-1.";
RL Proc. Natl. Acad. Sci. U.S.A. 97:12176-12181(2000).
CC -!- FUNCTION: Converts heme B (protoheme IX) to heme O by substitution
CC of the vinyl group on carbon 2 of heme B porphyrin ring with a
CC hydroxyethyl farnesyl side group (By similarity).
CC -!- PATHWAY: Porphyrin metabolism; heme O biosynthesis; heme O from
CC protoheme: step 1/1.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein
CC (Potential).
CC -!- MISCELLANEOUS: Carbon 2 of the heme B porphyrin ring is defined
CC according to the Fischer nomenclature (By similarity).
CC -!- SIMILARITY: In the C-terminal section; belongs to the UbiA
CC prenyltransferase family. Protoheme IX farnesyltransferase
CC subfamily.
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DR EMBL; AE004437; AAG19160.1; -; Genomic_DNA.
DR PIR; D84224; D84224.
DR RefSeq; NP_279680.1; NC_002607.1.
DR STRING; 64091.VNG0666G; -.
DR EnsemblBacteria; AAG19160; AAG19160; VNG_0666G.
DR GeneID; 1447466; -.
DR KEGG; hal:VNG0666G; -.
DR eggNOG; COG1612; -.
DR KO; K02301; -.
DR OMA; AFRAFHA; -.
DR ProtClustDB; CLSK511182; -.
DR UniPathway; UPA00834; UER00712.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016627; F:oxidoreductase activity, acting on the CH-CH group of donors; IEA:InterPro.
DR GO; GO:0008495; F:protoheme IX farnesyltransferase activity; IEA:HAMAP.
DR GO; GO:0006784; P:heme a biosynthetic process; IEA:InterPro.
DR GO; GO:0048034; P:heme O biosynthetic process; IEA:HAMAP.
DR HAMAP; MF_00154; CyoE_CtaB; 1; fused.
DR InterPro; IPR003780; HemeA_syn.
DR InterPro; IPR006369; Protohaem_IX_farnesylTrfase.
DR InterPro; IPR000537; UbiA_prenyltransferase.
DR Pfam; PF02628; COX15-CtaA; 1.
DR Pfam; PF01040; UbiA; 1.
DR TIGRFAMs; TIGR01473; cyoE_ctaB; 1.
DR PROSITE; PS00943; UBIA; FALSE_NEG.
PE 3: Inferred from homology;
KW Cell membrane; Complete proteome; Heme biosynthesis; Membrane;
KW Reference proteome; Transferase; Transmembrane; Transmembrane helix.
FT CHAIN 1 442 Protoheme IX farnesyltransferase.
FT /FTId=PRO_0000327195.
FT TRANSMEM 49 69 Helical; (Potential).
FT TRANSMEM 76 96 Helical; (Potential).
FT TRANSMEM 106 126 Helical; (Potential).
FT TRANSMEM 167 187 Helical; (Potential).
FT TRANSMEM 194 214 Helical; (Potential).
FT TRANSMEM 245 265 Helical; (Potential).
FT TRANSMEM 267 287 Helical; (Potential).
FT TRANSMEM 308 328 Helical; (Potential).
FT TRANSMEM 365 385 Helical; (Potential).
FT TRANSMEM 386 406 Helical; (Potential).
FT TRANSMEM 421 441 Helical; (Potential).
FT REGION 1 167 Unknown.
FT REGION 168 439 Prenyltransferase.
SQ SEQUENCE 442 AA; 46128 MW; A951E2B87C9FFE30 CRC64;
MGVYSLLVLG ATTSLTGAAS ACQTWPSCNG QWFALQSLDL VVVWGHRTAA ALTGLAVVGA
AVLAWRTGAS RRVRTAVTLA LALYPVQVVI GAYTAMSAGA APFTGVHLTL GVGIFASLVV
ALAWTLDAQT GDLPSAEWEG EPRHTDDGDP TQPGIVRAYV QLMKPRLMWL LCLVAGAGMA
LASSQLGAGQ QLSAATVVLT LGGGVLSIGA SGTFNHVLER EQDEKMARTD DRPVVTDRIP
PRNALAFGVV LGVASLAAFA AVNLLTAVLG LTAIAFYSIV YTLVLKPNTR QSTVIGGAAG
ALPALIGWVA VTGAVGVGGV VLAGVIFLWT PAHFYNLALA YKDDYERGGF PLMPVVEGEA
KTRRHIVYYI GATLASAVVL AELTGLGPLY AATTVLLGAV FLYFAIRLHR ERDRRAAMRS
FHASNAYLGC LLVAVVLDTM VV
//
