ID Q9HVE5_PSEAE Unreviewed; 427 AA.
AC Q9HVE5;
DT 01-MAR-2001, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2001, sequence version 1.
DT 27-MAR-2024, entry version 109.
DE SubName: Full=Uracil permease {ECO:0000313|EMBL:AAG08034.1};
GN Name=uraA {ECO:0000313|EMBL:AAG08034.1};
GN OrderedLocusNames=PA4647 {ECO:0000313|EMBL:AAG08034.1};
OS Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS 14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=208964 {ECO:0000313|EMBL:AAG08034.1, ECO:0000313|Proteomes:UP000002438};
RN [1] {ECO:0000313|EMBL:AAG08034.1, ECO:0000313|Proteomes:UP000002438}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 /
RC 1C / PRS 101 / PAO1 {ECO:0000313|Proteomes:UP000002438};
RX PubMed=10984043; DOI=10.1038/35023079;
RA Stover C.K., Pham X.Q., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA Hickey M.J., Brinkman F.S., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R., Smith K.,
RA Spencer D., Wong G.K., Wu Z., Paulsen I.T., Reizer J., Saier M.H.,
RA Hancock R.E., Lory S., Olson M.V.;
RT "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT pathogen.";
RL Nature 406:959-964(2000).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC
CC 2.A.40) family. {ECO:0000256|ARBA:ARBA00008821}.
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DR EMBL; AE004091; AAG08034.1; -; Genomic_DNA.
DR PIR; E83066; E83066.
DR RefSeq; NP_253336.1; NC_002516.2.
DR RefSeq; WP_003094970.1; NZ_QZGE01000029.1.
DR AlphaFoldDB; Q9HVE5; -.
DR SMR; Q9HVE5; -.
DR STRING; 208964.PA4647; -.
DR PaxDb; 208964-PA4647; -.
DR DNASU; 881278; -.
DR GeneID; 881278; -.
DR KEGG; pae:PA4647; -.
DR PATRIC; fig|208964.12.peg.4869; -.
DR PseudoCAP; PA4647; -.
DR HOGENOM; CLU_017959_1_2_6; -.
DR InParanoid; Q9HVE5; -.
DR OrthoDB; 9779092at2; -.
DR PhylomeDB; Q9HVE5; -.
DR BioCyc; PAER208964:G1FZ6-4743-MONOMER; -.
DR Proteomes; UP000002438; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0015205; F:nucleobase transmembrane transporter activity; IEA:UniProt.
DR InterPro; IPR006043; NCS2.
DR InterPro; IPR006042; Xan_ur_permease.
DR NCBIfam; TIGR00801; ncs2; 1.
DR PANTHER; PTHR11119:SF3; LD30822P; 1.
DR PANTHER; PTHR11119; XANTHINE-URACIL / VITAMIN C PERMEASE FAMILY MEMBER; 1.
DR Pfam; PF00860; Xan_ur_permease; 1.
DR PROSITE; PS01116; XANTH_URACIL_PERMASE; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002438};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 12..33
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 39..55
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 60..77
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 83..103
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 115..136
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 156..173
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 180..211
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 223..248
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 303..325
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 331..352
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 364..383
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 389..408
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 427 AA; 44226 MW; 9568BAECBE892CFE CRC64;
MGDAFQEPLW RQVLSGAQML FVAFGALVLM PLITGLDPNV ALFTAGLGTL LFQLVTGRQV
PVFLASSFAF ITPIILAKGQ FGLAATMGGV VAAGFVYTFM GLAVKIKGTG FIDKLLPPVV
IGPVIISIGL AMAPIAANMA MGKAGDGSEL LPYRTAMMIS MPALLTTLVV AVFGKGIFRL
VPIIAGVLVG FALSFVFGVV DTAAIVAAPW LELPKFTAPE FNWQAILFIV PVALAPAIEH
IGGVIAVGGV TGQDYLKKPG LHRTLLGDGL ATSAAGLFGG PPNTTYAEVT GAVMLTKNYN
PKIMTWAAVI AITLAFVGKF GAILQSIPVP VMGGILCLLF GTIASVGMNT LIRHKVDLSE
ARNLVIVSVT LVFGIGGVLI GSGTGPDDIG LKGIALCAIV AIVLNLLLPG NDGWQNKALD
EQHKDSH
//
