GenomeNet

Database: UniProt
Entry: Q9HZ55
LinkDB: Q9HZ55
Original site: Q9HZ55 
ID   RLUB_PSEAE              Reviewed;         386 AA.
AC   Q9HZ55;
DT   15-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   01-OCT-2014, entry version 74.
DE   RecName: Full=Ribosomal large subunit pseudouridine synthase B;
DE            EC=5.4.99.22;
DE   AltName: Full=23S rRNA pseudouridine(2605) synthase;
DE   AltName: Full=rRNA pseudouridylate synthase B;
DE   AltName: Full=rRNA-uridine isomerase B;
GN   Name=rluB; OrderedLocusNames=PA3179;
OS   Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG
OS   12228).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208964;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228;
RX   PubMed=10984043; DOI=10.1038/35023079;
RA   Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA   Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA   Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA   Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA   Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T.,
RA   Reizer J., Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT   "Complete genome sequence of Pseudomonas aeruginosa PAO1, an
RT   opportunistic pathogen.";
RL   Nature 406:959-964(2000).
CC   -!- FUNCTION: Responsible for synthesis of pseudouridine from uracil-
CC       2605 in 23S ribosomal RNA. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY: 23S rRNA uridine(2605) = 23S rRNA
CC       pseudouridine(2605).
CC   -!- SIMILARITY: Belongs to the pseudouridine synthase RsuA family.
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Contains 1 S4 RNA-binding domain.
CC       {ECO:0000255|PROSITE-ProRule:PRU00182}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AE004091; AAG06567.1; -; Genomic_DNA.
DR   PIR; E83247; E83247.
DR   RefSeq; NP_251869.1; NC_002516.2.
DR   ProteinModelPortal; Q9HZ55; -.
DR   SMR; Q9HZ55; 12-258.
DR   STRING; 208964.PA3179; -.
DR   EnsemblBacteria; AAG06567; AAG06567; PA3179.
DR   GeneID; 882705; -.
DR   KEGG; pae:PA3179; -.
DR   PATRIC; 19840925; VBIPseAer58763_3323.
DR   PseudoCAP; PA3179; -.
DR   eggNOG; COG1187; -.
DR   HOGENOM; HOG000044954; -.
DR   KO; K06178; -.
DR   OMA; FEMDREY; -.
DR   OrthoDB; EOG6130DV; -.
DR   PhylomeDB; Q9HZ55; -.
DR   GO; GO:0009982; F:pseudouridine synthase activity; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0001522; P:pseudouridine synthesis; IEA:InterPro.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 3.10.290.10; -; 1.
DR   InterPro; IPR020103; PsdUridine_synth_cat_dom.
DR   InterPro; IPR000748; PsdUridine_synth_RsuA/RluB/E/F.
DR   InterPro; IPR018496; PsdUridine_synth_RsuA/RluB_CS.
DR   InterPro; IPR006145; PsdUridine_synth_RsuA/RluD.
DR   InterPro; IPR002942; S4_RNA-bd.
DR   Pfam; PF00849; PseudoU_synth_2; 1.
DR   Pfam; PF01479; S4; 1.
DR   SMART; SM00363; S4; 1.
DR   SUPFAM; SSF55120; SSF55120; 1.
DR   TIGRFAMs; TIGR00093; TIGR00093; 1.
DR   PROSITE; PS01149; PSI_RSU; 1.
DR   PROSITE; PS50889; S4; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Isomerase; Reference proteome; RNA-binding;
KW   rRNA processing.
FT   CHAIN         1    386       Ribosomal large subunit pseudouridine
FT                                synthase B.
FT                                /FTId=PRO_0000099988.
FT   DOMAIN       14     75       S4 RNA-binding. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00182}.
FT   ACT_SITE    119    119       Nucleophile. {ECO:0000250}.
SQ   SEQUENCE   386 AA;  43725 MW;  C47840D7C0E5C0CC CRC64;
     MNDTPENPHV PVGEKLQKVL ARLGVGSRRD VEVWIAEGRV NVNGSVASLG QRVDSHDAIT
     VDGHLIRREE AAESVRRVLI YNKPEGEVCT RDDPEGRPTI FDRLPRLRTG RWINVGRLDI
     NTTGLLLFTT DGELANRLMH PSYEMDREYA VRVRGEVTEE MIERLLNGVM LEDGPAKFSD
     IQQAPGGEGF NHWYHCVVME GRNREVRRLW ESQGLVVSRL KRVRFGPVFL TSELTMGRYR
     EMDQREIDIL SEEVGLKPVA LPGMTTKARE KAERQQRKQA RPLARSERPE AGRKRAPRRE
     DGENAARRAP ASRPARGPQP SAERKGREQG TPVAERPRES NRKPRPSKPR DERPASAPGD
     KPAARKPQVK RRPKPAGDGM RPGFRR
//
DBGET integrated database retrieval system