ID Q9I0V5_PSEAE Unreviewed; 426 AA.
AC Q9I0V5;
DT 01-MAR-2001, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2001, sequence version 1.
DT 27-MAR-2024, entry version 112.
DE SubName: Full=Probable Resistance-Nodulation-Cell Division (RND) efflux membrane fusion protein {ECO:0000313|EMBL:AAG05916.1};
GN OrderedLocusNames=PA2528 {ECO:0000313|EMBL:AAG05916.1};
OS Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS 14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=208964 {ECO:0000313|EMBL:AAG05916.1, ECO:0000313|Proteomes:UP000002438};
RN [1] {ECO:0000313|EMBL:AAG05916.1, ECO:0000313|Proteomes:UP000002438}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 /
RC 1C / PRS 101 / PAO1 {ECO:0000313|Proteomes:UP000002438};
RX PubMed=10984043; DOI=10.1038/35023079;
RA Stover C.K., Pham X.Q., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA Hickey M.J., Brinkman F.S., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R., Smith K.,
RA Spencer D., Wong G.K., Wu Z., Paulsen I.T., Reizer J., Saier M.H.,
RA Hancock R.E., Lory S., Olson M.V.;
RT "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT pathogen.";
RL Nature 406:959-964(2000).
CC -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC family. {ECO:0000256|ARBA:ARBA00009477}.
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DR EMBL; AE004091; AAG05916.1; -; Genomic_DNA.
DR PIR; A83330; A83330.
DR RefSeq; NP_251218.1; NC_002516.2.
DR RefSeq; WP_003113320.1; NZ_QZGE01000008.1.
DR AlphaFoldDB; Q9I0V5; -.
DR SMR; Q9I0V5; -.
DR STRING; 208964.PA2528; -.
DR TCDB; 2.A.6.2.39; the resistance-nodulation-cell division (rnd) superfamily.
DR PaxDb; 208964-PA2528; -.
DR GeneID; 882937; -.
DR KEGG; pae:PA2528; -.
DR PATRIC; fig|208964.12.peg.2643; -.
DR PseudoCAP; PA2528; -.
DR HOGENOM; CLU_018816_2_0_6; -.
DR InParanoid; Q9I0V5; -.
DR OrthoDB; 9783047at2; -.
DR PhylomeDB; Q9I0V5; -.
DR BioCyc; PAER208964:G1FZ6-2563-MONOMER; -.
DR Proteomes; UP000002438; Chromosome.
DR GO; GO:1990281; C:efflux pump complex; IBA:GO_Central.
DR GO; GO:0015562; F:efflux transmembrane transporter activity; IBA:GO_Central.
DR Gene3D; 2.40.30.170; -; 1.
DR Gene3D; 2.40.420.20; -; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 1.10.287.470; Helix hairpin bin; 1.
DR InterPro; IPR039562; MFP_biotin_lipoyl_2.
DR InterPro; IPR006143; RND_pump_MFP.
DR NCBIfam; TIGR01730; RND_mfp; 1.
DR PANTHER; PTHR30469; MULTIDRUG RESISTANCE PROTEIN MDTA; 1.
DR PANTHER; PTHR30469:SF12; MULTIDRUG RESISTANCE PROTEIN MDTA; 1.
DR Pfam; PF13533; Biotin_lipoyl_2; 1.
DR Pfam; PF13437; HlyD_3; 1.
DR SUPFAM; SSF111369; HlyD-like secretion proteins; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002438};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 16..35
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 89..136
FT /note="Membrane fusion protein biotin-lipoyl like"
FT /evidence="ECO:0000259|Pfam:PF13533"
FT REGION 394..426
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 129..156
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 409..426
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 426 AA; 45276 MW; 5FC53D7F0E341168 CRC64;
MTPTTGKSKF RTLRPWLITA LAFAAVIGLV MWLAAPASAP SSDGRPGRGG KPGAALPKAN
ALTVGVARVE QGDLALHFNA LGTVTAFNTV NVKPRVNGEL VKVLFQEGQE VKAGDLLAVV
DPRTYKAALA QAEGTLMQNQ AQLKNAEIDL QRYKGLYAED SIAKQTLDTQ EAQVRQLQGT
IRTNQGQVDD ARLNLTFTEV RAPISGRLGL RQVDIGNLVT SGDTTPLVVI TQVKPISVVF
SLPQQQIGTV VEQMNGPGKL TVTALDRNQD KVLAEGTLTT LDNQIDTTTG TVKLKARFEN
ADGKLFPNQF VNVRLLAQTL KGVLTIPANA VQRGTNGIYV YVVGADNKVS QRSVAIGTSE
NERVVVESGL KAGEQVVVEG TDRLRDGMEV RVAEASPQVL EGEPQKPQTG RPSGLQGDSV
GSGSAE
//
