GenomeNet

Database: UniProt
Entry: Q9I1W0_PSEAE
LinkDB: Q9I1W0_PSEAE
Original site: Q9I1W0_PSEAE 
ID   Q9I1W0_PSEAE            Unreviewed;       401 AA.
AC   Q9I1W0;
DT   01-MAR-2001, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2001, sequence version 1.
DT   24-JAN-2024, entry version 114.
DE   RecName: Full=Cardiolipin synthase B {ECO:0000256|HAMAP-Rule:MF_01917};
DE            Short=CL synthase {ECO:0000256|HAMAP-Rule:MF_01917};
DE            EC=2.7.8.- {ECO:0000256|HAMAP-Rule:MF_01917};
GN   Name=clsB {ECO:0000256|HAMAP-Rule:MF_01917};
GN   OrderedLocusNames=PA2155 {ECO:0000313|EMBL:AAG05543.1};
OS   Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS   14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208964 {ECO:0000313|EMBL:AAG05543.1, ECO:0000313|Proteomes:UP000002438};
RN   [1] {ECO:0000313|EMBL:AAG05543.1, ECO:0000313|Proteomes:UP000002438}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 /
RC   1C / PRS 101 / PAO1 {ECO:0000313|Proteomes:UP000002438};
RX   PubMed=10984043; DOI=10.1038/35023079;
RA   Stover C.K., Pham X.Q., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA   Hickey M.J., Brinkman F.S., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA   Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA   Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R., Smith K.,
RA   Spencer D., Wong G.K., Wu Z., Paulsen I.T., Reizer J., Saier M.H.,
RA   Hancock R.E., Lory S., Olson M.V.;
RT   "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT   pathogen.";
RL   Nature 406:959-964(2000).
CC   -!- FUNCTION: Catalyzes the phosphatidyl group transfer from one
CC       phosphatidylglycerol molecule to another to form cardiolipin (CL)
CC       (diphosphatidylglycerol) and glycerol. {ECO:0000256|HAMAP-
CC       Rule:MF_01917}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) = a
CC         cardiolipin + glycerol; Xref=Rhea:RHEA:31451, ChEBI:CHEBI:17754,
CC         ChEBI:CHEBI:62237, ChEBI:CHEBI:64716; Evidence={ECO:0000256|HAMAP-
CC         Rule:MF_01917};
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|HAMAP-Rule:MF_01917};
CC       Peripheral membrane protein {ECO:0000256|HAMAP-Rule:MF_01917}.
CC   -!- SIMILARITY: Belongs to the phospholipase D family. Cardiolipin synthase
CC       subfamily. ClsB sub-subfamily. {ECO:0000256|HAMAP-Rule:MF_01917}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE004091; AAG05543.1; -; Genomic_DNA.
DR   PIR; B83377; B83377.
DR   RefSeq; NP_250845.1; NC_002516.2.
DR   RefSeq; WP_003113648.1; NZ_QZGE01000014.1.
DR   AlphaFoldDB; Q9I1W0; -.
DR   SMR; Q9I1W0; -.
DR   STRING; 208964.PA2155; -.
DR   PaxDb; 208964-PA2155; -.
DR   GeneID; 881323; -.
DR   KEGG; pae:PA2155; -.
DR   PATRIC; fig|208964.12.peg.2254; -.
DR   PseudoCAP; PA2155; -.
DR   HOGENOM; CLU_038053_0_0_6; -.
DR   InParanoid; Q9I1W0; -.
DR   OMA; GEEYFPR; -.
DR   OrthoDB; 9762009at2; -.
DR   PhylomeDB; Q9I1W0; -.
DR   BioCyc; PAER208964:G1FZ6-2195-MONOMER; -.
DR   Proteomes; UP000002438; Chromosome.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008808; F:cardiolipin synthase activity; IBA:GO_Central.
DR   GO; GO:0032049; P:cardiolipin biosynthetic process; IBA:GO_Central.
DR   CDD; cd09110; PLDc_CLS_1; 1.
DR   CDD; cd09159; PLDc_ybhO_like_2; 1.
DR   Gene3D; 3.30.870.10; Endonuclease Chain A; 3.
DR   HAMAP; MF_01917; Cardiolipin_synth_ClsB; 1.
DR   InterPro; IPR030872; Cardiolipin_synth_ClsB.
DR   InterPro; IPR025202; PLD-like_dom.
DR   InterPro; IPR001736; PLipase_D/transphosphatidylase.
DR   PANTHER; PTHR21248; CARDIOLIPIN SYNTHASE; 1.
DR   PANTHER; PTHR21248:SF23; CARDIOLIPIN SYNTHASE B; 1.
DR   Pfam; PF13091; PLDc_2; 2.
DR   SMART; SM00155; PLDc; 2.
DR   SUPFAM; SSF56024; Phospholipase D/nuclease; 2.
DR   PROSITE; PS50035; PLD; 2.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|HAMAP-Rule:MF_01917};
KW   Lipid biosynthesis {ECO:0000256|HAMAP-Rule:MF_01917};
KW   Lipid metabolism {ECO:0000256|HAMAP-Rule:MF_01917};
KW   Membrane {ECO:0000256|HAMAP-Rule:MF_01917};
KW   Phospholipid biosynthesis {ECO:0000256|HAMAP-Rule:MF_01917};
KW   Phospholipid metabolism {ECO:0000256|HAMAP-Rule:MF_01917};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002438};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transferase {ECO:0000256|HAMAP-Rule:MF_01917}.
FT   DOMAIN          108..135
FT                   /note="PLD phosphodiesterase"
FT                   /evidence="ECO:0000259|PROSITE:PS50035"
FT   DOMAIN          278..305
FT                   /note="PLD phosphodiesterase"
FT                   /evidence="ECO:0000259|PROSITE:PS50035"
FT   ACT_SITE        113
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01917"
FT   ACT_SITE        115
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01917"
FT   ACT_SITE        120
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01917"
FT   ACT_SITE        283
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01917"
FT   ACT_SITE        285
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01917"
FT   ACT_SITE        290
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01917"
SQ   SEQUENCE   401 AA;  46545 MW;  F6CD96B0EA32D2D6 CRC64;
     MNFPWRDGNR VELLINGEEY FPRLFQCIAE ARREILLETF IIFEDEVGRQ LQEALSAAAE
     RGVEVQVTVD GYGTASLSPD YLARLTASGV RVHLFDPRPR LLGMRTNLFR RLHRKLVVID
     RRQAFVGGIN YGEDHLVRRG NMAKQDYAVR VEGPVVRDIR QACLALLEPD ADYPPLRPSG
     AGQPARVRLV IRDNDQSSDD IEREYLQAIR QARRRLLIAN AYFFPGYRLL RELRDAARRG
     VRVDLVLQGM PDMPLVRLCS RLLYDYLLRE GVRIHEYCQR PLHGKVAVID DDWSTIGSSN
     LDPLSLSLNL EANLVIRDVA FNGQLYQHLR ELARRHCRRI SRRHARRGYW WRAPLIFLGF
     HFSRHFPAIA GWVPAHLPRL KSLEPRPSRR WQERQGQRGN P
//
DBGET integrated database retrieval system