ID Q9I243_PSEAE Unreviewed; 864 AA.
AC Q9I243;
DT 01-MAR-2001, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2001, sequence version 1.
DT 27-MAR-2024, entry version 119.
DE RecName: Full=Bifunctional diguanylate cyclase/phosphodiesterase {ECO:0008006|Google:ProtNLM};
GN OrderedLocusNames=PA2072 {ECO:0000313|EMBL:AAG05460.1};
OS Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS 14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=208964 {ECO:0000313|EMBL:AAG05460.1, ECO:0000313|Proteomes:UP000002438};
RN [1] {ECO:0000313|EMBL:AAG05460.1, ECO:0000313|Proteomes:UP000002438}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 /
RC 1C / PRS 101 / PAO1 {ECO:0000313|Proteomes:UP000002438};
RX PubMed=10984043; DOI=10.1038/35023079;
RA Stover C.K., Pham X.Q., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA Hickey M.J., Brinkman F.S., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R., Smith K.,
RA Spencer D., Wong G.K., Wu Z., Paulsen I.T., Reizer J., Saier M.H.,
RA Hancock R.E., Lory S., Olson M.V.;
RT "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT pathogen.";
RL Nature 406:959-964(2000).
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DR EMBL; AE004091; AAG05460.1; -; Genomic_DNA.
DR PIR; H83386; H83386.
DR RefSeq; NP_250762.1; NC_002516.2.
DR RefSeq; WP_010895599.1; NZ_QZGE01000022.1.
DR AlphaFoldDB; Q9I243; -.
DR SMR; Q9I243; -.
DR STRING; 208964.PA2072; -.
DR PaxDb; 208964-PA2072; -.
DR GeneID; 878516; -.
DR KEGG; pae:PA2072; -.
DR PATRIC; fig|208964.12.peg.2161; -.
DR PseudoCAP; PA2072; -.
DR HOGENOM; CLU_000445_91_1_6; -.
DR InParanoid; Q9I243; -.
DR OrthoDB; 9804951at2; -.
DR PhylomeDB; Q9I243; -.
DR BioCyc; PAER208964:G1FZ6-2110-MONOMER; -.
DR Proteomes; UP000002438; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd01948; EAL; 1.
DR CDD; cd01949; GGDEF; 1.
DR CDD; cd00130; PAS; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.20.20.450; EAL domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR InterPro; IPR007892; CHASE4.
DR InterPro; IPR001633; EAL_dom.
DR InterPro; IPR035919; EAL_sf.
DR InterPro; IPR000160; GGDEF_dom.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR NCBIfam; TIGR00254; GGDEF; 1.
DR NCBIfam; TIGR00229; sensory_box; 1.
DR PANTHER; PTHR44757; DIGUANYLATE CYCLASE DGCP; 1.
DR PANTHER; PTHR44757:SF12; MEMBRANE PROTEIN-RELATED; 1.
DR Pfam; PF05228; CHASE4; 1.
DR Pfam; PF00563; EAL; 1.
DR Pfam; PF00990; GGDEF; 1.
DR SMART; SM00052; EAL; 1.
DR SMART; SM00267; GGDEF; 1.
DR SMART; SM00091; PAS; 1.
DR SUPFAM; SSF141868; EAL domain-like; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR PROSITE; PS50883; EAL; 1.
DR PROSITE; PS50887; GGDEF; 1.
DR PROSITE; PS50112; PAS; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002438};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..41
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 255..273
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 301..355
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 454..587
FT /note="GGDEF"
FT /evidence="ECO:0000259|PROSITE:PS50887"
FT DOMAIN 596..846
FT /note="EAL"
FT /evidence="ECO:0000259|PROSITE:PS50883"
FT REGION 845..864
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 864 AA; 95151 MW; 7D6DE5C753A4D4F8 CRC64;
MLASAIASGT AVSQVSKHLL MFLAALFLAL GACGWAILHI ARHQDDIAIE QSHFYVEKAL
QNRRENSEQF STTYSFWTDA YVYLGNRVDA DWAFTKNNLG SVLYTTNGYD GVFVIDDRGT
RYAMLEGELS ERSLADSLNA DTGDILRSAR RAAVDEAAIS RYVDFDGAPA ILVASAIKPT
SDHAPIDLAK ASVMVFVDRL TPAKLAKLGG DYGIANLHLL AGGAAGDKES LALEGTPHRL
AWVSSRPGSA MLRETALPLL GIFVLAAGLL FWLSRSAVLN ARAVDRQQKV LKRSNQALLA
SEERFKSIAE AASDWIWEVD GHFVFTYLSV RFRDVTGYQP EAWIGRRLDE LLDSDTVNIV
KWLEGLPDAG APSSLVCAFR DSQGQARVGK LSASAIRNGV ASGYRGTAAD ITDEVEAHAK
IQHLSLHDAL TGLPNRNKLF QFLERLLAEK AGKSPVAVLM LDLDRFKPIN DQHGHPAGDA
VLYAIAERLR ASTRDQDMVA RLGGDEFVVV STHVSSKLEI EKFCSRLIDV INREVAYEGH
SFHVGASIGV ALAPEHGGDP RGLLRCADVA MYEAKAAGRN TWRFYLEAMD SHLAEKKLRE
TELRAALQNG EFELYYQPRF LAQEQTIASA EALIRWNHPR RGLIGPDEFI GLAEESDLIV
QIGNWVLREA CATAASWPGE VMVSVNVSPA QFMTGDIVWQ VREALRLARL DARRLELEVT
ENVMLNDVDG ALRTMTALKE LGVRLNMDDF GTGYSSLGYL RTYPFDSIKI DKRFVASMEK
TGRDRSIVQA IINLGNALNL RVTAEGVETE GQMHILRDEQ CHELQGFLLS RPLDAQRLRD
LLEREAGQTQ APQVSAEGHA ARRP
//
