ID Q9I2Q9_PSEAE Unreviewed; 193 AA.
AC Q9I2Q9;
DT 01-MAR-2001, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2001, sequence version 1.
DT 27-MAR-2024, entry version 142.
DE SubName: Full=Probable transcriptional regulator {ECO:0000313|EMBL:AAG05225.1};
GN OrderedLocusNames=PA1836 {ECO:0000313|EMBL:AAG05225.1};
OS Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS 14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=208964 {ECO:0000313|EMBL:AAG05225.1, ECO:0000313|Proteomes:UP000002438};
RN [1] {ECO:0000313|EMBL:AAG05225.1, ECO:0000313|Proteomes:UP000002438}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 /
RC 1C / PRS 101 / PAO1 {ECO:0000313|Proteomes:UP000002438};
RX PubMed=10984043; DOI=10.1038/35023079;
RA Stover C.K., Pham X.Q., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA Hickey M.J., Brinkman F.S., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R., Smith K.,
RA Spencer D., Wong G.K., Wu Z., Paulsen I.T., Reizer J., Saier M.H.,
RA Hancock R.E., Lory S., Olson M.V.;
RT "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT pathogen.";
RL Nature 406:959-964(2000).
RN [2] {ECO:0007829|PDB:2GEN}
RP X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS), AND DISULFIDE BONDS.
RA Tan K., Skarina T., Onopriyenko O., Savchenko A., Edwards A.,
RA Joachimiak A.;
RT "The crystal structure of a probable transcriptional regulator from
RT Pseudomonas aeruginosa PAO1.";
RL Submitted (MAR-2006) to the PDB data bank.
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DR EMBL; AE004091; AAG05225.1; -; Genomic_DNA.
DR PIR; D83417; D83417.
DR RefSeq; NP_250527.1; NC_002516.2.
DR RefSeq; WP_003098179.1; NZ_QZGE01000003.1.
DR PDB; 2GEN; X-ray; 1.70 A; A=1-193.
DR PDBsum; 2GEN; -.
DR AlphaFoldDB; Q9I2Q9; -.
DR SMR; Q9I2Q9; -.
DR STRING; 208964.PA1836; -.
DR PaxDb; 208964-PA1836; -.
DR DNASU; 880628; -.
DR GeneID; 880628; -.
DR KEGG; pae:PA1836; -.
DR PATRIC; fig|208964.12.peg.1906; -.
DR PseudoCAP; PA1836; -.
DR HOGENOM; CLU_069356_12_9_6; -.
DR InParanoid; Q9I2Q9; -.
DR OrthoDB; 5816932at2; -.
DR PhylomeDB; Q9I2Q9; -.
DR BioCyc; PAER208964:G1FZ6-1874-MONOMER; -.
DR EvolutionaryTrace; Q9I2Q9; -.
DR Proteomes; UP000002438; Chromosome.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IBA:GO_Central.
DR Gene3D; 1.10.357.10; Tetracycline Repressor, domain 2; 1.
DR InterPro; IPR023772; DNA-bd_HTH_TetR-type_CS.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001647; HTH_TetR.
DR InterPro; IPR036271; Tet_transcr_reg_TetR-rel_C_sf.
DR PANTHER; PTHR30055; HTH-TYPE TRANSCRIPTIONAL REGULATOR RUTR; 1.
DR PANTHER; PTHR30055:SF223; HTH-TYPE TRANSCRIPTIONAL REGULATOR UIDR; 1.
DR Pfam; PF00440; TetR_N; 1.
DR PRINTS; PR00455; HTHTETR.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR SUPFAM; SSF48498; Tetracyclin repressor-like, C-terminal domain; 1.
DR PROSITE; PS01081; HTH_TETR_1; 1.
DR PROSITE; PS50977; HTH_TETR_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure {ECO:0007829|PDB:2GEN};
KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00335};
KW Reference proteome {ECO:0000313|Proteomes:UP000002438}.
FT DOMAIN 4..64
FT /note="HTH tetR-type"
FT /evidence="ECO:0000259|PROSITE:PS50977"
FT DNA_BIND 27..46
FT /note="H-T-H motif"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00335"
SQ SEQUENCE 193 AA; 21316 MW; 964A478A767939F4 CRC64;
MGRSSRKDEI LQAALACFSE HGVDATTIEM IRDRSGASIG SLYHHFGNKE RIHGELYLAG
IGQYAALLEA GFARARSAEE TVRLLVTSYI DWVVANPDWA RFILHSRGRV EAGELGERLR
ADNQAHFARI HAALAGYRAE GLFREMPDDC FASVVIGPAH DLARQWLAGR TRVALADCRE
LLAQVAWDSV RAA
//
