ID Q9J2X7_9HIV1 Unreviewed; 200 AA.
AC Q9J2X7;
DT 01-OCT-2000, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2000, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Reverse transcriptase {ECO:0000313|EMBL:AAF27511.1};
DE Flags: Fragment;
GN Name=pol {ECO:0000313|EMBL:AAF27511.1};
OS Human immunodeficiency virus 1.
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX NCBI_TaxID=11676 {ECO:0000313|EMBL:AAF27511.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:AAF27511.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=11061664; DOI=10.1097/00002030-200009290-00019;
RA Romano L., Venturi G., Ferruzzi R., Riccio M.L., Corsi P., Leoncini F.,
RA Vinattieri A., Incandela L., Valensin P.E., Zazzi M.;
RT "Detection of genotypically drug-resistant HIV-1 variants and non-B
RT subtypes in recently infected antiretroviral-naive adults in Italy.";
RL AIDS 14:2204-2206(2000).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF209290; AAF27511.1; -; Genomic_DNA.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR000477; RT_dom.
DR PANTHER; PTHR41694; ENDOGENOUS RETROVIRUS GROUP K MEMBER POL PROTEIN; 1.
DR PANTHER; PTHR41694:SF3; RNA-DIRECTED DNA POLYMERASE-RELATED; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 4: Predicted;
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918,
KW ECO:0000313|EMBL:AAF27511.1}; Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Viral release from host cell {ECO:0000256|ARBA:ARBA00023113};
KW Virion maturation {ECO:0000256|ARBA:ARBA00023113}.
FT DOMAIN 15..200
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AAF27511.1"
FT NON_TER 200
FT /evidence="ECO:0000313|EMBL:AAF27511.1"
SQ SEQUENCE 200 AA; 23248 MW; C471EF3B21855F63 CRC64;
KIKALTEICL EMEKEGKISK IGPENPYNTP VFAIKKKDST KWRKLVDFRE LNKRTQDFWE
VQLGIPHPAG LKKKKSVTVL DVGDAYFSVP LDKDFRKYTA FTIPSVNNET PGIRYQYNVL
PQGWKGSPAI FQASMTKILE PFRTKNPEIV IYQYMDDLXV GSDLEIGQHR AKIEELREHL
LKWGFTTPDK KHQKEPPFLW
//
