ID IL22B_MOUSE Reviewed; 179 AA.
AC Q9JJY8; E9QAL9;
DT 16-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2012, sequence version 2.
DT 01-MAY-2013, entry version 88.
DE RecName: Full=Interleukin-22b;
DE Short=IL-22b;
DE AltName: Full=IL-10-related T-cell-derived-inducible factor beta;
DE Short=IL-TIF beta;
DE Short=IL-TIFb;
DE Flags: Precursor;
GN Name=Il22b; Synonyms=Iltifb;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC Muroidea; Muridae; Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=129;
RX PubMed=10657629;
RA Dumoutier L., Louahed J., Renauld J.-C.;
RT "Cloning and characterization of IL-10-related T cell-derived
RT inducible factor (IL-TIF), a novel cytokine structurally related to
RT IL-10 and inducible by IL-9.";
RL J. Immunol. 164:1814-1819(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=129;
RX PubMed=11197690; DOI=10.1038/sj.gene.6363716;
RA Dumoutier L., Van Roost E., Colau D., Ameye G., Michaux L.,
RA Renauld J.-C.;
RT "IL-TIF/IL-22: genomic organization and mapping of the human and mouse
RT genes.";
RL Genes Immun. 1:488-494(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
RA Lindblad-Toh K., Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of
RT the mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- FUNCTION: Cytokine that contributes to the inflammatory response
CC in vivo.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the IL-10 family.
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DR EMBL; AJ249492; CAB75547.1; -; mRNA.
DR EMBL; AJ294728; CAC19436.1; -; Genomic_DNA.
DR EMBL; AC158600; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR IPI; IPI00122407; -.
DR IPI; IPI00953777; -.
DR RefSeq; NP_473420.2; NM_054079.2.
DR UniGene; Mm.213193; -.
DR ProteinModelPortal; Q9JJY8; -.
DR SMR; Q9JJY8; 40-179.
DR STRING; 10090.ENSMUSP00000094449; -.
DR PRIDE; Q9JJY8; -.
DR Ensembl; ENSMUST00000163808; ENSMUSP00000128415; ENSMUSG00000090461.
DR GeneID; 116849; -.
DR KEGG; mmu:116849; -.
DR CTD; 116849; -.
DR MGI; MGI:2151139; Iltifb.
DR eggNOG; NOG42949; -.
DR GeneTree; ENSGT00510000048550; -.
DR HOGENOM; HOG000280686; -.
DR HOVERGEN; HBG018572; -.
DR InParanoid; Q9JJY8; -.
DR OMA; YIRNRTY; -.
DR OrthoDB; EOG4DJJXR; -.
DR NextBio; 369202; -.
DR Genevestigator; Q9JJY8; -.
DR GermOnline; ENSMUSG00000074695; Mus musculus.
DR GermOnline; ENSMUSG00000074723; Mus musculus.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR012351; 4_helix_cytokine_core.
DR InterPro; IPR020443; Interleukin-10/19/20/24.
DR InterPro; IPR020423; Interleukin-10_CS.
DR InterPro; IPR020453; Interleukin-22.
DR Pfam; PF00726; IL10; 1.
DR PRINTS; PR01936; INTRLEUKIN22.
DR SMART; SM00188; IL10; 1.
DR SUPFAM; SSF47266; 4_helix_cytokine; 1.
DR PROSITE; PS00520; INTERLEUKIN_10; 1.
PE 2: Evidence at transcript level;
KW Complete proteome; Cytokine; Disulfide bond; Glycoprotein;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1 33 Potential.
FT CHAIN 34 179 Interleukin-22b.
FT /FTId=PRO_0000015385.
FT CARBOHYD 54 54 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 68 68 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 97 97 N-linked (GlcNAc...) (Potential).
FT DISULFID 40 132 By similarity.
FT DISULFID 89 178 By similarity.
FT CONFLICT 63 63 V -> A (in Ref. 1; CAB75547 and 2;
FT CAC19436).
FT CONFLICT 73 73 W -> R (in Ref. 1; CAB75547 and 2;
FT CAC19436).
FT CONFLICT 103 103 V -> I (in Ref. 1; CAB75547 and 2;
FT CAC19436).
FT CONFLICT 112 112 Q -> R (in Ref. 1; CAB75547 and 2;
FT CAC19436).
SQ SEQUENCE 179 AA; 20179 MW; FAF43A9701812482 CRC64;
MAVLQKSMSF SLMGTLAASC LLLIALWAQE ANALPINTRC KLEVSNFQQP YIVNRTFMLA
KEVSLADNNT DVWLIGEKLF RGVSAKDQCY LMKQVLNFTL EDVLLPQSDR FQPYMQEVVP
FLTKLSNQLS SCHISGDDQN IQKNVRRLKE TVKKLGESGE IKAIGELDLL FMSLRNACV
//
