ID Q9K2Z6_ECOLX Unreviewed; 152 AA.
AC Q9K2Z6;
DT 01-OCT-2000, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2000, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Shikimate dehydrogenase {ECO:0000313|EMBL:AAF97096.1};
DE Flags: Fragment;
GN Name=aroE {ECO:0000313|EMBL:AAF97096.1};
OS Escherichia coli.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=562 {ECO:0000313|EMBL:AAF97096.1};
RN [1] {ECO:0000313|EMBL:AAF97096.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=90-1787 {ECO:0000313|EMBL:AAF97093.1}, B2F1
RC {ECO:0000313|EMBL:AAF97095.1}, CL-3 {ECO:0000313|EMBL:AAF97094.1},
RC CL-37 {ECO:0000313|EMBL:AAF97088.1}, DEC9f
RC {ECO:0000313|EMBL:AAF97089.1}, and G5506
RC {ECO:0000313|EMBL:AAF97096.1};
RX PubMed=10894541; DOI=10.1038/35017546;
RA Reid S.D., Herbelin C.J., Bumbaugh A.C., Selander R.K., Whittam T.S.;
RT "Parallel evolution of virulence in pathogenic Escherichia coli.";
RL Nature 406:64-67(2000).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF267548; AAF97088.1; -; Genomic_DNA.
DR EMBL; AF267549; AAF97089.1; -; Genomic_DNA.
DR EMBL; AF267553; AAF97093.1; -; Genomic_DNA.
DR EMBL; AF267554; AAF97094.1; -; Genomic_DNA.
DR EMBL; AF267555; AAF97095.1; -; Genomic_DNA.
DR EMBL; AF267556; AAF97096.1; -; Genomic_DNA.
DR AlphaFoldDB; Q9K2Z6; -.
DR GO; GO:0004764; F:shikimate 3-dehydrogenase (NADP+) activity; IEA:InterPro.
DR CDD; cd01065; NAD_bind_Shikimate_DH; 1.
DR Gene3D; 3.40.50.10860; Leucine Dehydrogenase, chain A, domain 1; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR046346; Aminoacid_DH-like_N_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR022893; Shikimate_DH_fam.
DR InterPro; IPR006151; Shikm_DH/Glu-tRNA_Rdtase.
DR PANTHER; PTHR21089:SF1; BIFUNCTIONAL 3-DEHYDROQUINATE DEHYDRATASE_SHIKIMATE DEHYDROGENASE, CHLOROPLASTIC; 1.
DR PANTHER; PTHR21089; SHIKIMATE DEHYDROGENASE; 1.
DR Pfam; PF01488; Shikimate_DH; 1.
DR SUPFAM; SSF53223; Aminoacid dehydrogenase-like, N-terminal domain; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT DOMAIN 49..118
FT /note="Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA
FT reductase"
FT /evidence="ECO:0000259|Pfam:PF01488"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AAF97096.1"
FT NON_TER 152
FT /evidence="ECO:0000313|EMBL:AAF97096.1"
SQ SEQUENCE 152 AA; 16179 MW; 6B4F8F8357B9CB56 CRC64;
DELTERAALA GAVNTLKRLE NGRLLGDNTD GIGLLSDLER LSFIRPGLRI LLIGAGGASR
GVLLPLLSLD CAVTITNRTV SRAEELAKLF AHTGSIQALG MDELEGHEFD LIINATSSGI
SGDIPAIPSS LIHPGIYCYD MFYQKGKTPF LA
//
