ID DNAA_ACHLA Reviewed; 445 AA.
AC Q9KHU8;
DT 01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 08-NOV-2023, entry version 95.
DE RecName: Full=Chromosomal replication initiator protein DnaA;
GN Name=dnaA;
OS Acholeplasma laidlawii.
OC Bacteria; Mycoplasmatota; Mollicutes; Acholeplasmatales;
OC Acholeplasmataceae; Acholeplasma.
OX NCBI_TaxID=2148;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=PG-8B;
RX PubMed=10779957;
RA Taganov K.D., Gushchin A.E., Akopian T.A., Oparina N.Y., Abramycheva N.Y.,
RA Govorun V.M.;
RT "Analysis of genes, coding for DNA gyrase from the mycoplasma Acholeplasma
RT laidlawii PG-8B.";
RL Mol. Biol. (Mosk.) 34:292-299(2000).
CC -!- FUNCTION: Plays an important role in the initiation and regulation of
CC chromosomal replication. Binds to the origin of replication; it binds
CC specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-
CC TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000305}.
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DR EMBL; AF248639; AAF75986.1; -; Genomic_DNA.
DR AlphaFoldDB; Q9KHU8; -.
DR SMR; Q9KHU8; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR CDD; cd00009; AAA; 1.
DR CDD; cd06571; Bac_DnaA_C; 1.
DR Gene3D; 1.10.1750.10; -; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 3.30.300.180; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00377; DnaA_bact; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR001957; Chromosome_initiator_DnaA.
DR InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR InterPro; IPR013317; DnaA.
DR InterPro; IPR013159; DnaA_C.
DR InterPro; IPR024633; DnaA_N_dom.
DR InterPro; IPR038454; DnaA_N_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010921; Trp_repressor/repl_initiator.
DR NCBIfam; TIGR00362; DnaA; 1.
DR PANTHER; PTHR30050; CHROMOSOMAL REPLICATION INITIATOR PROTEIN DNAA; 1.
DR PANTHER; PTHR30050:SF2; CHROMOSOMAL REPLICATION INITIATOR PROTEIN DNAA; 1.
DR Pfam; PF00308; Bac_DnaA; 1.
DR Pfam; PF08299; Bac_DnaA_C; 1.
DR Pfam; PF11638; DnaA_N; 1.
DR PRINTS; PR00051; DNAA.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00760; Bac_DnaA_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48295; TrpR-like; 1.
DR PROSITE; PS01008; DNAA; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cytoplasm; DNA replication; DNA-binding; Nucleotide-binding.
FT CHAIN 1..445
FT /note="Chromosomal replication initiator protein DnaA"
FT /id="PRO_0000114117"
FT BINDING 144..151
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
SQ SEQUENCE 445 AA; 51047 MW; A6045EE53F8C9DB3 CRC64;
MSPNSTLWQT ILQDLEKLYN EETYNELFLP VTSTFKDQNG LLTMVVANEF LKNRINKLYI
AKINELATKY SSTPVRLKFV SQEEVIEEPV ADRKLTIDYR QGNLNSTYTF DSFVVGKSNM
FAFRMAMKVA DHPGAVANPF YIFGDVGLGK THLMQAIGNY ILDNDVEKRI LYVKADNFIE
DFVSLLSRNK NKTEEFNAKY KDIDVILVDD IQIMANASKT QMEFFKLFDY LYLNNKQIVI
TSDKPASQLT NIMPRLTTRF EAGLSVDIQI PELEHRISIL KRKTATLDAN LEVSEDILTF
IASQFAANIR EMEGALIRLI SYAQTFNLEI TMNVVEEALG AVLKTKKKTN DLNENNYDKI
QSIVADYFQV SLPDLIGKKR HAKFTLPRHI AMYLIKLKYN IPYKTIGSLF NDRDHSTVLS
ACEKVERDMR MDSNLKFAVD SIVKK
//
