ID MTSA_STRMU Reviewed; 306 AA.
AC Q9KIJ3;
DT 18-OCT-2001, integrated into UniProtKB/Swiss-Prot.
DT 28-NOV-2002, sequence version 2.
DT 29-MAY-2013, entry version 88.
DE RecName: Full=Metal ABC transporter substrate-binding lipoprotein;
DE Flags: Precursor;
GN Name=sloC; OrderedLocusNames=SMU_184;
OS Streptococcus mutans serotype c (strain ATCC 700610 / UA159).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=210007;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 25175 / DSM 20523 / JCM 5705 / NBRC 13955 / NCIMB 702062 /
RC NCTC 10449;
RX PubMed=10899841; DOI=10.1128/IAI.68.8.4441-4451.2000;
RA Kitten T., Munro C.L., Michalek S.M., Macrina F.L.;
RT "Genetic characterization of a Streptococcus mutans LraI family operon
RT and role in virulence.";
RL Infect. Immun. 68:4441-4451(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700610 / UA159;
RX PubMed=12397186; DOI=10.1073/pnas.172501299;
RA Ajdic D.J., McShan W.M., McLaughlin R.E., Savic G., Chang J.,
RA Carson M.B., Primeaux C., Tian R., Kenton S., Jia H.G., Lin S.P.,
RA Qian Y., Li S., Zhu H., Najar F.Z., Lai H., White J., Roe B.A.,
RA Ferretti J.J.;
RT "Genome sequence of Streptococcus mutans UA159, a cariogenic dental
RT pathogen.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:14434-14439(2002).
CC -!- FUNCTION: Part of an ATP-driven transport system for a metal;
CC probably for manganese. Also act as an adhesin which is involved
CC on adherence to extracellular matrix. It is an important factor in
CC pathogenesis and infection. It may contribute to the formation and
CC accumulation of dental plaque.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor (By similarity).
CC -!- SIMILARITY: Belongs to the bacterial solute-binding protein 9
CC family. Lipoprotein receptor antigen (Lrai) subfamily.
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DR EMBL; AF232688; AAF81674.1; -; Genomic_DNA.
DR EMBL; AE014133; AAN57959.1; -; Genomic_DNA.
DR RefSeq; NP_720653.1; NC_004350.2.
DR ProteinModelPortal; Q9KIJ3; -.
DR SMR; Q9KIJ3; 25-306.
DR STRING; 210007.SMU.184; -.
DR EnsemblBacteria; AAN57959; AAN57959; SMU_184.
DR GeneID; 1029755; -.
DR KEGG; smu:SMU_184; -.
DR PATRIC; 19662617; VBIStrMut61772_0160.
DR eggNOG; COG0803; -.
DR KO; K11704; -.
DR OMA; IPSAYIW; -.
DR ProtClustDB; CLSK876868; -.
DR BioCyc; SMUT210007:GC7Z-189-MONOMER; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR GO; GO:0030001; P:metal ion transport; IEA:InterPro.
DR InterPro; IPR006129; AdhesinB.
DR InterPro; IPR006128; Lipoprotein_4.
DR InterPro; IPR006127; Perip_solute-bd_prot_fam.
DR Pfam; PF01297; SBP_bac_9; 1.
DR PRINTS; PR00691; ADHESINB.
DR PRINTS; PR00690; ADHESNFAMILY.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Cell membrane; Complete proteome; Lipoprotein; Manganese; Membrane;
KW Metal-binding; Palmitate; Signal; Transport; Zinc.
FT SIGNAL 1 19 Probable.
FT CHAIN 20 306 Metal ABC transporter substrate-binding
FT lipoprotein.
FT /FTId=PRO_0000031888.
FT METAL 64 64 Zinc (By similarity).
FT METAL 136 136 Zinc (By similarity).
FT METAL 202 202 Zinc (By similarity).
FT METAL 277 277 Zinc (By similarity).
FT LIPID 20 20 N-palmitoyl cysteine (Probable).
FT LIPID 20 20 S-diacylglycerol cysteine (Probable).
FT CONFLICT 108 108 T -> A (in Ref. 1; AAF81674).
FT CONFLICT 302 302 N -> D (in Ref. 1; AAF81674).
SQ SEQUENCE 306 AA; 34365 MW; CDA294394F24AB29 CRC64;
MKKLSLLLLV CLSLLGLFAC TSKKTADKKL TVVATNSIIA DITKNIAGNK VVLHSIVPVG
RDPHEYEPLP EDVKKTSQAD VIFYNGINLE NGGNAWFTKL VKNAHKKTDK DYFAVSDSVK
TIYLENAKEK GKEDPHAWLD LKNGIIYAKN IMKRLSEKDP KNKSYYQKNF QAYSAKLEKL
HKVAKEKISR IPTEKKMIVT SEGCFKYFSK AYDIPSAYIW EINTEEEGTP NQIKALVKKL
RKSRVSALFV ESSVDDRPMK TVSKDTGIPI AAKIFTDSVA KKGQAGDSYY AMMKWNIDKI
ANGLSQ
//
