ID Q9KSW2_VIBCH Unreviewed; 756 AA.
AC Q9KSW2;
DT 01-OCT-2000, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2000, sequence version 1.
DT 27-MAR-2024, entry version 128.
DE SubName: Full=ATP-dependent Clp protease, ATP-binding subunit ClpA {ECO:0000313|EMBL:AAF94303.1};
GN OrderedLocusNames=VC_1144 {ECO:0000313|EMBL:AAF94303.1};
OS Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Vibrio.
OX NCBI_TaxID=243277 {ECO:0000313|EMBL:AAF94303.1, ECO:0000313|Proteomes:UP000000584};
RN [1] {ECO:0000313|EMBL:AAF94303.1, ECO:0000313|Proteomes:UP000000584}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 39315 / El Tor Inaba N16961
RC {ECO:0000313|Proteomes:UP000000584};
RX PubMed=10952301; DOI=10.1038/35020000;
RA Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L.,
RA Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A., Gill S.R.,
RA Nelson K.E., Read T.D., Tettelin H., Richardson D., Ermolaeva M.D.,
RA Vamathevan J., Bass S., Qin H., Dragoi I., Sellers P., McDonald L.,
RA Utterback T., Fleishmann R.D., Nierman W.C., White O., Salzberg S.L.,
RA Smith H.O., Colwell R.R., Mekalanos J.J., Venter J.C., Fraser C.M.;
RT "DNA sequence of both chromosomes of the cholera pathogen Vibrio
RT cholerae.";
RL Nature 406:477-483(2000).
CC -!- SIMILARITY: Belongs to the ClpA/ClpB family.
CC {ECO:0000256|ARBA:ARBA00008675, ECO:0000256|RuleBase:RU004432}.
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DR EMBL; AE003852; AAF94303.1; -; Genomic_DNA.
DR PIR; E82236; E82236.
DR RefSeq; NP_230789.1; NC_002505.1.
DR RefSeq; WP_000932415.1; NZ_LT906614.1.
DR AlphaFoldDB; Q9KSW2; -.
DR STRING; 243277.VC_1144; -.
DR DNASU; 2614577; -.
DR EnsemblBacteria; AAF94303; AAF94303; VC_1144.
DR GeneID; 69720165; -.
DR KEGG; vch:VC_1144; -.
DR PATRIC; fig|243277.26.peg.1093; -.
DR eggNOG; COG0542; Bacteria.
DR HOGENOM; CLU_005070_4_1_6; -.
DR Proteomes; UP000000584; Chromosome 1.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0034605; P:cellular response to heat; IBA:GO_Central.
DR GO; GO:0043335; P:protein unfolding; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00009; AAA; 1.
DR CDD; cd19499; RecA-like_ClpB_Hsp104-like; 1.
DR Gene3D; 1.10.8.60; -; 2.
DR Gene3D; 1.10.1780.10; Clp, N-terminal domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR019489; Clp_ATPase_C.
DR InterPro; IPR036628; Clp_N_dom_sf.
DR InterPro; IPR004176; Clp_R_dom.
DR InterPro; IPR013461; ClpA.
DR InterPro; IPR001270; ClpA/B.
DR InterPro; IPR018368; ClpA/B_CS1.
DR InterPro; IPR028299; ClpA/B_CS2.
DR InterPro; IPR041546; ClpA/ClpB_AAA_lid.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR02639; ClpA; 1.
DR PANTHER; PTHR11638; ATP-DEPENDENT CLP PROTEASE; 1.
DR PANTHER; PTHR11638:SF111; ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPA; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF07724; AAA_2; 1.
DR Pfam; PF17871; AAA_lid_9; 1.
DR Pfam; PF02861; Clp_N; 1.
DR Pfam; PF10431; ClpB_D2-small; 1.
DR PRINTS; PR00300; CLPPROTEASEA.
DR SMART; SM00382; AAA; 2.
DR SMART; SM01086; ClpB_D2-small; 1.
DR SUPFAM; SSF81923; Double Clp-N motif; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51903; CLP_R; 1.
DR PROSITE; PS00870; CLPAB_1; 1.
DR PROSITE; PS00871; CLPAB_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU004432};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|RuleBase:RU004432};
KW Hydrolase {ECO:0000313|EMBL:AAF94303.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU004432}; Protease {ECO:0000313|EMBL:AAF94303.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000584};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|PROSITE-
KW ProRule:PRU01251}.
FT DOMAIN 1..145
FT /note="Clp R"
FT /evidence="ECO:0000259|PROSITE:PS51903"
SQ SEQUENCE 756 AA; 84024 MW; 2EA49A7C7EF5D3A9 CRC64;
MLNKELESSL NGAFARARDK RHEFMTVEHL LLALLENDAA REALLACQAD IDVLRRELDT
FIDQTTPLIP KNDETRETQP TLSFQRVLQR AVFHVQSSGR SEVTGANVLV AIFSEQESHA
AYLLKKNDIS RLDIVNFISH GITKASNHSE DSSSDSFGSS DTSEEVSADE RLESFATNLN
QLAKQGQIDP LIGRDKELER TIQVLCRRRK NNPLLVGEAG VGKTAIAEGL AWRIVEGNVP
EVIQRSVIYS LDIGSLLAGT KYRGDFEKRF KSILKQLEKE KDAILFIDEI HTIIGAGAAS
GGQVDAANLI KPLLSSGKLR CIGSTTYQEY SNIFEKERAL SRRFQKIDIV EPSLDDTTKI
LMGLKTKYEA HHDVRYTNKA LRAAVELSAK YINERHLPDK AIDVIDEAGA RARLMPASRR
KKTVGVAEIE SMVAKMARIP EKSVSSSDKD ILKNLDQKMK MLVFGQDAAI DVLTEAIKLT
RAGLGAEHKP VGSFLFAGPT GVGKTEVTLQ LSKLLGIELL RFDMSEYGER HSVSRLIGAP
PGYVGYDQGG LLTDAVIKHP HSVVLLDEIE KAHPDIFNLL LQVMDNGTLT DNNGRKADFR
NVILVMTTNA GVAETVKKSI GLIQQDNSHD AMSEIKKVFT PEFRNRLDHI IWFNSLDERV
IHQVVDKFIV ELQAQLDARG VSLEVSEDAR HWLAVKGYDR EMGARPMGRV IQEQLKKPLA
NELLFGSLVD GGTVKVTLSD DRLAFEYFGT REEVVH
//
