ID Q9M8X8_ARATH Unreviewed; 896 AA.
AC Q9M8X8;
DT 01-OCT-2000, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2000, sequence version 1.
DT 27-MAR-2024, entry version 145.
DE SubName: Full=Disease resistance protein (TIR-NBS-LRR class) family {ECO:0000313|EMBL:ANM64069.1};
DE SubName: Full=Putative disease resistance protein {ECO:0000313|EMBL:AAF26791.1};
GN OrderedLocusNames=At3g04220 {ECO:0000313|Araport:AT3G04220,
GN ECO:0000313|EMBL:ANM64069.1};
GN ORFNames=T6K12.16 {ECO:0000313|EMBL:AAF26791.1}, T6K12_16
GN {ECO:0000313|EMBL:ANM64069.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000313|EMBL:AAF26791.1};
RN [1] {ECO:0000313|EMBL:ANM64069.1, ECO:0000313|Proteomes:UP000006548}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia {ECO:0000313|Proteomes:UP000006548};
RX PubMed=11130713; DOI=10.1038/35048706;
RG European Union Chromosome 3 Arabidopsis Sequencing Consortium;
RG Institute for Genomic Research;
RG Kazusa DNA Research Institute;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Blocker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M.,
RA Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N.,
RA Artiguenave F., Robert C., Brottier P., Wincker P., Cattolico L.,
RA Weissenbach J., Saurin W., Quetier F., Schafer M., Muller-Auer S.,
RA Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H., Erfle H., Jordan N.,
RA Bangert S., Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P.,
RA Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A., Toppo S.,
RA Simionati B., Conrad A., Hornischer K., Kauer G., Lohnert T.H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schon O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwalder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.W., Mayer K.F., Kaul S.,
RA Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2] {ECO:0000313|EMBL:AAF26791.1}
RP NUCLEOTIDE SEQUENCE.
RA Lin X., Kaul S., Town C.D., Benito M.-I., Creasy T.H., Haas B., Wu D.,
RA Ronning C.M., Koo H., Fujii C.Y., Utterback T.R., Barnstead M.E.,
RA Bowman C.L., White O., Nierman W.C., Fraser C.M.;
RT "Arabidopsis thaliana chromosome III BAC T6K12 genomic sequence.";
RL Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:ANM64069.1}
RP NUCLEOTIDE SEQUENCE.
RG TAIR;
RA Swarbreck D., Lamesch P., Wilks C., Huala E.;
RL Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:ANM64069.1}
RP NUCLEOTIDE SEQUENCE.
RA Krishnakumar V., Cheng C.-Y., Chan A.P., Schobel S., Kim M., Ferlanti E.S.,
RA Belyaeva I., Rosen B.D., Micklem G., Miller J.R., Vaughn M., Town C.D.;
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|Proteomes:UP000006548}
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia {ECO:0000313|Proteomes:UP000006548};
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
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DR EMBL; AC016829; AAF26791.1; -; Genomic_DNA.
DR EMBL; CP002686; ANM64069.1; -; Genomic_DNA.
DR RefSeq; NP_001326120.1; NM_001337508.1.
DR AlphaFoldDB; Q9M8X8; -.
DR SMR; Q9M8X8; -.
DR STRING; 3702.Q9M8X8; -.
DR ProteomicsDB; 174935; -.
DR EnsemblPlants; AT3G04220.3; AT3G04220.3; AT3G04220.
DR GeneID; 819577; -.
DR Gramene; AT3G04220.3; AT3G04220.3; AT3G04220.
DR Araport; AT3G04220; -.
DR TAIR; AT3G04220; -.
DR OMA; NIRVRYP; -.
DR OrthoDB; 693000at2759; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9M8X8; baseline and differential.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR011713; Leu-rich_rpt_3.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11017:SF411; ADP-RIBOSYL CYCLASE_CYCLIC ADP-RIBOSE HYDROLASE-RELATED; 1.
DR PANTHER; PTHR11017; LEUCINE-RICH REPEAT-CONTAINING PROTEIN; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF07725; LRR_3; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50104; TIR; 1.
PE 1: Evidence at protein level;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|SAM:Phobius}; NAD {ECO:0000256|ARBA:ARBA00023027};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Proteomics identification {ECO:0007829|PeptideAtlas:Q9M8X8,
KW ECO:0007829|ProteomicsDB:Q9M8X8};
KW Reference proteome {ECO:0000313|Proteomes:UP000006548};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..28
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 61..225
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT REGION 37..58
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 42..58
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 896 AA; 102043 MW; 6E9243DE9B024817 CRC64;
MDSSFLLETV AAATGFFTLL GTILFMVYRK FKDHRENKEN DSSSSTQPSP SPPLSSLSLT
RKYDVFPSFR GEDVRKDFLS HIQKEFQRQG ITPFVDNNIK RGESIGPELI RAIRGSKIAI
ILLSKNYASS SWCLDELVEI IKCKEEMGQT VIVIFYKVDP SLVKKLTGDF GKVFRNTCKG
KERENIERWR EAFKKVATIA GYDSRKWDNE SGMIEKIVSD ISEMLNHSTP SRDFDDLIGM
GDHMEKMKPL LDIDSDEMKT IGIWGPPGVG KTTIARSLYN QHSDKFQLSV FMESIKTAYT
IPACSDDYYE KLQLQQRFLS QITNQENVQI PHLGVAQERL NDKKVLVVID DVNQSVQVDA
LAKENDWLGP GSRIIITTQD RGILRAHGIE HIYEVDYPNY EEALQIFCMH AFGQKSPYDG
FEELAQQVTT LSGRLPLGLK VMGSYFRGMT KQEWTMALPR VRTHLDGKIE SILKLSYDAL
CDVDKSLFLH LACSFHNDDT ELVEQQLGKK FSDLRQGLHV LAEKSLIHMD LRLIRMHVLL
AQLGREIVRK QSIHEPGQRQ FLVDATDIRE VLTDDTGSRS VIGIDFDFNT MEKELDISEK
AFRGMSNLQF IRIYGDLFSR HGVYYFGGRG HRVSLDYDSK LHFPRGLDYL PGKLRLLHWQ
QFPMTSLPSE FHAEFLVKLC MPYSKLEKLW EGIQPLRNLE WLDLTCSRNL KELPDLSTAT
NLQRLSIERC SSLVKLPSSI GEATNLKKIN LRECLSLVEL PSSFGNLTNL QELDLRECSS
LVELPTSFGN LANVESLEFY ECSSLVKLPS TFGNLTNLRV LGLRECSSMV ELPSSFGNLT
NLQVLNLRKC STLVELPSSF VNLTNLENLD LRDCSSLLPS SFGNVTYLKR LKFYKC
//
