ID HDG8_ARATH Reviewed; 699 AA.
AC Q9M9P4; Q8GY47;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 29-APR-2008, sequence version 2.
DT 24-JAN-2024, entry version 143.
DE RecName: Full=Homeobox-leucine zipper protein HDG8 {ECO:0000303|PubMed:16778018};
DE AltName: Full=HD-ZIP protein HDG8 {ECO:0000303|PubMed:16778018};
DE AltName: Full=Homeodomain GLABRA 2-like protein 8 {ECO:0000303|PubMed:10809443};
DE AltName: Full=Homeodomain transcription factor HDG8 {ECO:0000303|PubMed:16778018};
DE AltName: Full=Protein HOMEODOMAIN GLABROUS 8 {ECO:0000303|PubMed:16778018};
GN Name=HDG8 {ECO:0000303|PubMed:16778018};
GN Synonyms=HDGL2-8 {ECO:0000303|PubMed:10809443};
GN OrderedLocusNames=At3g03260 {ECO:0000312|Araport:AT3G03260};
GN ORFNames=T17B22.5 {ECO:0000312|EMBL:AAF26121.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=11910074; DOI=10.1126/science.1071006;
RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA Shinagawa A., Shinozaki K.;
RT "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL Science 296:141-145(2002).
RN [4]
RP GENE FAMILY.
RX PubMed=10809443; DOI=10.1023/a:1006368316413;
RA Tavares R., Aubourg S., Lecharny A., Kreis M.;
RT "Organization and structural evolution of four multigene families in
RT Arabidopsis thaliana: AtLCAD, AtLGT, AtMYST and AtHD-GL2.";
RL Plant Mol. Biol. 42:703-717(2000).
RN [5]
RP TISSUE SPECIFICITY, GENE FAMILY, AND NOMENCLATURE.
RX PubMed=16778018; DOI=10.1104/pp.106.077388;
RA Nakamura M., Katsumata H., Abe M., Yabe N., Komeda Y., Yamamoto K.T.,
RA Takahashi T.;
RT "Characterization of the class IV homeodomain-leucine zipper gene family in
RT Arabidopsis.";
RL Plant Physiol. 141:1363-1375(2006).
RN [6]
RP INTERACTION WITH ANT.
RC STRAIN=cv. Columbia;
RX PubMed=25564655; DOI=10.1242/dev.117168;
RA Horstman A., Fukuoka H., Muino J.M., Nitsch L., Guo C., Passarinho P.,
RA Sanchez-Perez G., Immink R., Angenent G., Boutilier K.;
RT "AIL and HDG proteins act antagonistically to control cell proliferation.";
RL Development 142:454-464(2015).
CC -!- FUNCTION: Probable transcription factor. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with ANT. {ECO:0000269|PubMed:25564655}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in the embryo at early stage and in the
CC endosperm. {ECO:0000269|PubMed:16778018}.
CC -!- SIMILARITY: Belongs to the HD-ZIP homeobox family. Class IV subfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF26121.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=BAC42508.1; Type=Frameshift; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC012328; AAF26121.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002686; AEE73918.1; -; Genomic_DNA.
DR EMBL; AK117867; BAC42508.1; ALT_FRAME; mRNA.
DR RefSeq; NP_186976.2; NM_111196.2.
DR AlphaFoldDB; Q9M9P4; -.
DR SMR; Q9M9P4; -.
DR STRING; 3702.Q9M9P4; -.
DR PaxDb; 3702-AT3G03260-1; -.
DR ProteomicsDB; 230314; -.
DR EnsemblPlants; AT3G03260.1; AT3G03260.1; AT3G03260.
DR GeneID; 821305; -.
DR Gramene; AT3G03260.1; AT3G03260.1; AT3G03260.
DR KEGG; ath:AT3G03260; -.
DR Araport; AT3G03260; -.
DR TAIR; AT3G03260; HDG8.
DR eggNOG; ENOG502QTNV; Eukaryota.
DR HOGENOM; CLU_015002_2_1_1; -.
DR InParanoid; Q9M9P4; -.
DR OMA; QDCYMDA; -.
DR OrthoDB; 4250502at2759; -.
DR PhylomeDB; Q9M9P4; -.
DR PRO; PR:Q9M9P4; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9M9P4; baseline and differential.
DR Genevisible; Q9M9P4; AT.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR CDD; cd08875; START_ArGLABRA2_like; 1.
DR Gene3D; 3.30.530.20; -; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR042160; GLABRA2/ANL2/PDF2/ATML1-like.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR023393; START-like_dom_sf.
DR InterPro; IPR002913; START_lipid-bd_dom.
DR PANTHER; PTHR45654:SF63; HOMEOBOX-LEUCINE ZIPPER PROTEIN HDG8; 1.
DR PANTHER; PTHR45654; HOMEOBOX-LEUCINE ZIPPER PROTEIN MERISTEM L1; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF01852; START; 1.
DR SMART; SM00389; HOX; 1.
DR SMART; SM00234; START; 1.
DR SUPFAM; SSF55961; Bet v1-like; 2.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS50848; START; 1.
PE 1: Evidence at protein level;
KW Coiled coil; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..699
FT /note="Homeobox-leucine zipper protein HDG8"
FT /id="PRO_0000331669"
FT DOMAIN 204..438
FT /note="START"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00197"
FT DNA_BIND 23..82
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 89..149
FT /evidence="ECO:0000255"
FT COMPBIAS 1..21
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 699 AA; 78426 MW; 3EB8723000AA005E CRC64;
MDNNGGGSSG NEQYTSGDAK QNGKRTCHRH TPQQIQRLEA YFKECPHPDE RQRNQLCREL
KLEPDQIKFW FQNKRTQSKT QEDRSTNVLL RGENETLQSD NEAMLDALKS VLCPACGGPP
FGREERGHNL QKLRFENARL KDHRDRISNF VDQHKPNEPT VEDSLAYVPS LDRISYGING
GNMYEPSSSY GPPNFQIIQP RPLAETDMSL LSEIAASAVE ELKRLFLAEE QFWVKSCIDE
TYVIDTESYE RFSHAVKHFS STTAHVESSK AVTVVHVEAI NLIQMFLDPE KWKELFPTIV
NKANTIHVLG SGLPIRGNCN VLQVMWEQLH ILSPLVPARE FMVVRCCQEI EKGIWIIADV
SHRANFDFGN AACYKRPSGC LIQALPDAHS KVMWIEHVEV DHKLDTHKIY RDLLSGGSGY
GAKRWIVTLE RMCERMALSS IQTLPPSDRS EVITTGEARR SVMKLGERMV KNFNEMLTMS
GKIDFPQQSK NGVRVSIRMN IEAGQPPGIV VSASSSLAIP LTPLQVFAFL QNLDTRQQWD
ILSYGTVVNE IARIVTGSSE TNCVTILRVH PTHEENNDKM VVQDSCKDDM LMLQDCYMDA
LGGMIVYAPM DMATMHFAVS GEVDPSHIPI LPSGFVISSD GRRSTVEDGG TLLTVAFQIL
VSGKANRSRE VNEKSVDTVS ALISSTIQRI KGLLNCPEC
//
