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Database: UniProt
Entry: Q9M9Z2
LinkDB: Q9M9Z2
Original site: Q9M9Z2 
ID   TPP2_ARATH              Reviewed;         367 AA.
AC   Q9M9Z2; Q8LEC9;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   11-JUN-2014, entry version 101.
DE   RecName: Full=Probable thylakoidal processing peptidase 2, chloroplastic;
DE            EC=3.4.21.89;
DE   AltName: Full=Signal peptidase I-2;
DE   Flags: Precursor;
GN   Name=TPP2; OrderedLocusNames=At1g06870; ORFNames=F4H5.6;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
OC   Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae;
OC   Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S.,
RA   White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y.,
RA   Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W.,
RA   Chung M.K., Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K.,
RA   Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y.,
RA   Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L.,
RA   Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E.,
RA   Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B.,
RA   Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P.,
RA   Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A.,
RA   Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I.,
RA   Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D.,
RA   Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M.,
RA   Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M.,
RA   Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis
RT   thaliana.";
RL   Nature 408:816-820(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RG   The Arabidopsis Information Resource (TAIR);
RL   Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA   Feldmann K.A.;
RT   "Full-length cDNA from Arabidopsis thaliana.";
RL   Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RA   Shinn P., Chen H., Kim C.J., Ecker J.R.;
RT   "Arabidopsis ORF clones.";
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Cleaves the thylakoid-transfer domain from a chloroplast
CC       protein (By similarity).
CC   -!- CATALYTIC ACTIVITY: Cleavage of hydrophobic, N-terminal signal or
CC       leader sequences from secreted and periplasmic proteins.
CC   -!- SUBCELLULAR LOCATION: Plastid, chloroplast thylakoid membrane;
CC       Single-pass membrane protein. Note=located in the non-appressed
CC       lamellae of the thylakoid network (By similarity).
CC   -!- SIMILARITY: Belongs to the peptidase S26 family.
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DR   EMBL; AC011001; AAF63136.1; -; Genomic_DNA.
DR   EMBL; CP002684; AEE28047.1; -; Genomic_DNA.
DR   EMBL; AY085489; AAM62715.1; -; mRNA.
DR   EMBL; BT024745; ABD59083.1; -; mRNA.
DR   PIR; E86203; E86203.
DR   RefSeq; NP_172171.1; NM_100563.3.
DR   UniGene; At.23784; -.
DR   ProteinModelPortal; Q9M9Z2; -.
DR   SMR; Q9M9Z2; 235-328.
DR   ChEMBL; CHEMBL1932907; -.
DR   MEROPS; S26.A01; -.
DR   PRIDE; Q9M9Z2; -.
DR   EnsemblPlants; AT1G06870.1; AT1G06870.1; AT1G06870.
DR   GeneID; 837198; -.
DR   KEGG; ath:AT1G06870; -.
DR   GeneFarm; 2115; 205.
DR   TAIR; AT1G06870; -.
DR   eggNOG; COG0681; -.
DR   HOGENOM; HOG000243179; -.
DR   InParanoid; Q9M9Z2; -.
DR   KO; K03100; -.
DR   OMA; PIDYEME; -.
DR   PhylomeDB; Q9M9Z2; -.
DR   BioCyc; ARA:AT1G06870-MONOMER; -.
DR   PRO; PR:Q9M9Z2; -.
DR   Genevestigator; Q9M9Z2; -.
DR   GO; GO:0009535; C:chloroplast thylakoid membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008236; F:serine-type peptidase activity; IEA:InterPro.
DR   Gene3D; 2.10.109.10; -; 2.
DR   InterPro; IPR000223; Pept_S26A_signal_pept_1.
DR   InterPro; IPR019758; Pept_S26A_signal_pept_1_CS.
DR   InterPro; IPR019756; Pept_S26A_signal_pept_1_Ser-AS.
DR   InterPro; IPR028360; Peptidase_S24/S26_b-rbn.
DR   InterPro; IPR015927; Peptidase_S24_S26A/B/C.
DR   InterPro; IPR019533; Peptidase_S26.
DR   PANTHER; PTHR12383; PTHR12383; 1.
DR   Pfam; PF10502; Peptidase_S26; 1.
DR   PRINTS; PR00727; LEADERPTASE.
DR   SUPFAM; SSF51306; SSF51306; 1.
DR   TIGRFAMs; TIGR02227; sigpep_I_bact; 1.
DR   PROSITE; PS00501; SPASE_I_1; 1.
DR   PROSITE; PS00761; SPASE_I_3; 1.
PE   2: Evidence at transcript level;
KW   Chloroplast; Complete proteome; Hydrolase; Membrane; Plastid;
KW   Protease; Reference proteome; Thylakoid; Transit peptide;
KW   Transmembrane; Transmembrane helix.
FT   TRANSIT       1     68       Chloroplast (Potential).
FT   TRANSIT      69      ?       Thylakoid (Potential).
FT   CHAIN         ?    367       Probable thylakoidal processing peptidase
FT                                2, chloroplastic.
FT                                /FTId=PRO_0000310735.
FT   TRANSMEM    185    205       Helical; (Potential).
FT   TOPO_DOM    206    367       Lumenal, thylakoid (Potential).
FT   ACT_SITE    214    214       By similarity.
FT   CONFLICT    111    111       M -> V (in Ref. 3; AAM62715).
FT   CONFLICT    196    196       V -> F (in Ref. 3; AAM62715).
SQ   SEQUENCE   367 AA;  40150 MW;  BE18813DE031BBAE CRC64;
     MAIRVTFTYS SYVARSIASS AGTRVGTGDV RSCFETWVRP RFCGHNQIPD IVDKSPGSNT
     WGPSSGPRAR PASSMYSTIA REILEEGCKS PLVLGMISLM NLTGAPQFSG MTGLGISPFK
     TSSVIPFLRG SKWMPCSIPA TLSTDIAEVD RGGKVCDPKV KLELSDKVSN GGNGWVNKLL
     NICSEDAKAA FTAVTVSLLF RSALAEPKSI PSTSMLPTLD VGDRVIAEKV SYFFRKPEVS
     DIVIFKAPPI LVEHGYSCAD VFIKRIVASE GDWVEVCDGK LLVNDTVQAE DFVLEPIDYE
     MEPMFVPEGY VFVLGDNRNK SFDSHNWGPL PIKNIIGRSV FRYWPPSKVS DIIHHEQVSQ
     KRAVDVS
//
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