ID Q9MYJ8_CALJA Unreviewed; 355 AA.
AC Q9MYJ8;
DT 01-OCT-2000, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2000, sequence version 1.
DT 27-MAR-2024, entry version 118.
DE SubName: Full=Chemokine receptor {ECO:0000313|EMBL:AAF36453.1, ECO:0000313|Ensembl:ENSCJAP00000040531.2};
GN Name=CCR1 {ECO:0000313|EMBL:AAF36453.1,
GN ECO:0000313|Ensembl:ENSCJAP00000040531.2};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|EMBL:AAF36453.1};
RN [1] {ECO:0000313|EMBL:AAF36453.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=10686294; DOI=10.1016/S0014-2999(99)00863-8;
RA Liang M., Rosser M., Ng H.P., May K., Bauman J.G., Islam I., Ghannam A.,
RA Kretschmer P.J., Pu H., Dunning L., Snider R.M., Morrissey M.M.,
RA Hesselgesser J., Perez H.D., Horuk R.;
RT "Species selectivity of a small molecule antagonist for the CCR1 chemokine
RT receptor.";
RL Eur. J. Pharmacol. 389:41-49(2000).
RN [2] {ECO:0000313|Ensembl:ENSCJAP00000040531.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSCJAP00000040531.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000256|RuleBase:RU000688}.
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DR EMBL; AF127528; AAF36453.1; -; mRNA.
DR RefSeq; NP_001171970.1; NM_001185041.1.
DR RefSeq; XP_008979717.1; XM_008981469.1.
DR STRING; 9483.ENSCJAP00000040531; -.
DR Ensembl; ENSCJAT00000042815.4; ENSCJAP00000040531.2; ENSCJAG00000021830.4.
DR GeneID; 100398059; -.
DR KEGG; cjc:100398059; -.
DR CTD; 1230; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT01020000230359; -.
DR HOGENOM; CLU_009579_8_3_1; -.
DR OMA; SHYTCSL; -.
DR OrthoDB; 4604454at2759; -.
DR TreeFam; TF330966; -.
DR Proteomes; UP000008225; Chromosome 15.
DR Bgee; ENSCJAG00000021830; Expressed in liver and 5 other cell types or tissues.
DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
DR GO; GO:0016493; F:C-C chemokine receptor activity; IEA:Ensembl.
DR GO; GO:0071791; F:chemokine (C-C motif) ligand 5 binding; IEA:Ensembl.
DR GO; GO:0035717; F:chemokine (C-C motif) ligand 7 binding; IEA:Ensembl.
DR GO; GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:Ensembl.
DR GO; GO:0006816; P:calcium ion transport; IEA:Ensembl.
DR GO; GO:0007267; P:cell-cell signaling; IEA:Ensembl.
DR GO; GO:0006935; P:chemotaxis; IEA:InterPro.
DR GO; GO:0006887; P:exocytosis; IEA:Ensembl.
DR GO; GO:0006955; P:immune response; IEA:Ensembl.
DR GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR GO; GO:0006874; P:intracellular calcium ion homeostasis; IEA:Ensembl.
DR GO; GO:0030502; P:negative regulation of bone mineralization; IEA:Ensembl.
DR GO; GO:0010629; P:negative regulation of gene expression; IEA:Ensembl.
DR GO; GO:0051928; P:positive regulation of calcium ion transport; IEA:Ensembl.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IEA:Ensembl.
DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
DR GO; GO:0090026; P:positive regulation of monocyte chemotaxis; IEA:Ensembl.
DR GO; GO:0045672; P:positive regulation of osteoclast differentiation; IEA:Ensembl.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR002236; Chemokine_CCR1.
DR InterPro; IPR000355; Chemokine_rcpt.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR PANTHER; PTHR10489:SF711; C-C CHEMOKINE RECEPTOR TYPE 1; 1.
DR PANTHER; PTHR10489; CELL ADHESION MOLECULE; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00657; CCCHEMOKINER.
DR PRINTS; PR01106; CHEMOKINER1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|RuleBase:RU000688};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|RuleBase:RU000688, ECO:0000313|EMBL:AAF36453.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW Transducer {ECO:0000256|ARBA:ARBA00023224, ECO:0000256|RuleBase:RU000688};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000688};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 40..60
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 72..91
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 111..134
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 146..166
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 205..227
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 239..261
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 281..304
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 51..301
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
SQ SEQUENCE 355 AA; 40929 MW; 2B01C47E9874A2C1 CRC64;
METSATTEDY DMITEFDYSD ATPCHKANER AFGAKLLPPL YSLVFVIGLV GNILVVVVLV
QYKRLKNMTS IYLLNLAISD LLFLFTLPFW ISYQLKTDWV FGNAMCKVLS GFYYTGLYSE
IFFIILLTID RYLAIVHAVF ALRARTVTFG VITSIIIWVL AILASLPGLY FAKTQWEITH
RTCSLHFPHE SRQEWKLFQA LKLNLLGLVL PLLVMIVCYT GIIKILLRRP NEKKSKAVRL
IFVIMIIFFL FWTPYNLTTL ISVFQDFLFT YGCEQGRQLD LAIQVTEMIA YTHCCVNPVI
YAFVGERFRK HLRQLFHRRV AVHLVKWLPF LSVDRLERAS STSPSTGEHE VSAGF
//