ID Q9N2I6_FELCA Unreviewed; 249 AA.
AC Q9N2I6;
DT 01-OCT-2000, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2000, sequence version 1.
DT 27-MAR-2024, entry version 79.
DE RecName: Full=Low affinity immunoglobulin gamma Fc region receptor III-A {ECO:0000256|ARBA:ARBA00040880};
GN Name=CD16 {ECO:0000313|EMBL:BAA92347.1};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|EMBL:BAA92347.1};
RN [1] {ECO:0000313|EMBL:BAA92347.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=10713347; DOI=10.1016/S0165-2427(00)00156-2;
RA Nishimura Y., Miyazawa T., Ikeda Y., Izumiya Y., Nakamura K., Sato E.,
RA Mikami T., Takahashi E.;
RT "Molecular cloning and sequencing of the cDNA encoding the feline
RT FcgammaRIIIA (CD16) homologue.";
RL Vet. Immunol. Immunopathol. 73:353-359(2000).
CC -!- SUBUNIT: Forms a heterooligomeric complex with ITAM-containing
CC signaling subunits FCER1G. Interacts (via transmembrane domain) with
CC signaling subunits; this interaction is a prerequisite for receptor
CC complex expression on the cell surface and intracellular signal
CC transduction. Binds the Fc region of antigen-complexed IgG.
CC {ECO:0000256|ARBA:ARBA00038604}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB025314; BAA92347.1; -; mRNA.
DR RefSeq; XP_006943061.1; XM_006942999.3.
DR AlphaFoldDB; Q9N2I6; -.
DR GeneID; 493677; -.
DR CTD; 2214; -.
DR HOGENOM; CLU_023383_1_0_1; -.
DR OrthoDB; 5261894at2759; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019864; F:IgG binding; IEA:UniProtKB-KW.
DR CDD; cd05753; Ig2_FcgammaR_like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR PANTHER; PTHR11481; IMMUNOGLOBULIN FC RECEPTOR; 1.
DR PANTHER; PTHR11481:SF103; LOW AFFINITY IMMUNOGLOBULIN GAMMA FC REGION RECEPTOR III-A-RELATED; 1.
DR Pfam; PF13895; Ig_2; 2.
DR SMART; SM00409; IG; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR PROSITE; PS50835; IG_LIKE; 2.
PE 2: Evidence at transcript level;
KW Membrane {ECO:0000256|SAM:Phobius}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..249
FT /note="Low affinity immunoglobulin gamma Fc region receptor
FT III-A"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004330731"
FT TRANSMEM 204..227
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 31..104
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 119..188
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 249 AA; 27902 MW; 683528C68A7CAB7A CRC64;
MWRLLSPTAL LLLVSAGTRA DLSKAMVVLE PEWNRVLVSD GVILKCEGAY PPGDNSAQWW
HNGSVIPHRA PSYSIEAARS EDSGEYKCQT GLSEASDPVQ LEVHTGWLLL QAPRWVFQEG
DTIQLRCHSW KNKTVQKVQY FQDGRGKMFF HKNSDFYIPK ATSKHSGSYF CRGLIGNKNE
SSEAVNITVQ GPPVPSTSTF LPHWYQIAFF LVTALLFVVD TGLHVAVQRD LQSSVKEWKD
GKVTWSHGP
//
