ID Q9N3H3_CAEEL Unreviewed; 431 AA.
AC Q9N3H3;
DT 01-OCT-2000, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2001, sequence version 2.
DT 27-MAR-2024, entry version 132.
DE RecName: Full=NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial {ECO:0000256|ARBA:ARBA00040720};
DE AltName: Full=Complex I-39kD {ECO:0000256|ARBA:ARBA00043145};
DE AltName: Full=NADH-ubiquinone oxidoreductase 39 kDa subunit {ECO:0000256|ARBA:ARBA00042000};
GN Name=nduf-9 {ECO:0000313|EMBL:CCD72292.1,
GN ECO:0000313|WormBase:Y53G8AL.2};
GN ORFNames=CELE_Y53G8AL.2 {ECO:0000313|EMBL:CCD72292.1}, Y53G8AL.2
GN {ECO:0000313|WormBase:Y53G8AL.2};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CCD72292.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CCD72292.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CCD72292.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- SIMILARITY: Belongs to the complex I NDUFA9 subunit family.
CC {ECO:0000256|ARBA:ARBA00038501}.
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DR EMBL; BX284603; CCD72292.1; -; Genomic_DNA.
DR RefSeq; NP_497675.1; NM_065274.5.
DR AlphaFoldDB; Q9N3H3; -.
DR SMR; Q9N3H3; -.
DR STRING; 6239.Y53G8AL.2.1; -.
DR EPD; Q9N3H3; -.
DR PaxDb; 6239-Y53G8AL-2; -.
DR PeptideAtlas; Q9N3H3; -.
DR EnsemblMetazoa; Y53G8AL.2.1; Y53G8AL.2.1; WBGene00021800.
DR GeneID; 175429; -.
DR KEGG; cel:CELE_Y53G8AL.2; -.
DR UCSC; Y53G8AL.2.1; c. elegans.
DR AGR; WB:WBGene00021800; -.
DR WormBase; Y53G8AL.2; CE26163; WBGene00021800; nduf-9.
DR eggNOG; KOG2865; Eukaryota.
DR GeneTree; ENSGT00390000006865; -.
DR HOGENOM; CLU_007383_6_4_1; -.
DR InParanoid; Q9N3H3; -.
DR OMA; VLTRNMQ; -.
DR OrthoDB; 141210at2759; -.
DR PhylomeDB; Q9N3H3; -.
DR Reactome; R-CEL-6799198; Complex I biogenesis.
DR PRO; PR:Q9N3H3; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00021800; Expressed in germ line (C elegans) and 4 other cell types or tissues.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; ISS:WormBase.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0044877; F:protein-containing complex binding; IBA:GO_Central.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:WormBase.
DR GO; GO:1901006; P:ubiquinone-6 biosynthetic process; IBA:GO_Central.
DR CDD; cd05271; NDUFA9_like_SDR_a; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR001509; Epimerase_deHydtase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR12126:SF11; NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 9, MITOCHONDRIAL; 1.
DR PANTHER; PTHR12126; NADH-UBIQUINONE OXIDOREDUCTASE 39 KDA SUBUNIT-RELATED; 1.
DR Pfam; PF01370; Epimerase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|EPD:Q9N3H3,
KW ECO:0007829|PeptideAtlas:Q9N3H3};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940}.
FT DOMAIN 62..277
FT /note="NAD-dependent epimerase/dehydratase"
FT /evidence="ECO:0000259|Pfam:PF01370"
FT REGION 400..431
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 411..431
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 431 AA; 48254 MW; D5ADA2DDC3952A2C CRC64;
MLSVLGRSGL GARQAVSVVG SQNFSSAVTS AENAHPEPRV SSQSAQFRKG AGGRASFSGN
VVTVFGASGF LGLPVVNKFA KNGSQIIIPY RQDPYYMREH KVLGELGQVL YFPFELMDEE
SIRKAVKYSN VVINLIGTRV PTGKYNYYDV NDTGARRLAR ICKEMGVEKF VHLSALGATT
QPQKGHFVAK SQFLHSKGLG EVAVREEFPE ATIIRPSVIY GELDGFIQYY VSRWRKTPLD
YVYLYKKGEE TYKMPIWVGD VAAGIQSAVN DPTAKGHTYE FVGPHCYQLS ELIDFMYKKA
HCLSDFGFRY KRHGMPDPYF MALTMATELY GKVFKCKVPL NREWMEFVEV QSDILTGERT
LADLGVRRLT EFELAGGQQA FYRSFNRYFE EQYGELPAPS LPLRSPPLTK KNTGRGATGI
KSETSKNVAF N
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