ID Q9NCM4_PLAVI Unreviewed; 588 AA.
AC Q9NCM4;
DT 01-OCT-2000, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2000, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=Merozoite surface protein 1 {ECO:0000256|ARBA:ARBA00022062};
DE AltName: Full=Merozoite surface antigen {ECO:0000256|ARBA:ARBA00031689};
DE AltName: Full=PMMSA {ECO:0000256|ARBA:ARBA00032276};
DE Flags: Fragment;
OS Plasmodium vivax (malaria parasite P. vivax).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Plasmodium).
OX NCBI_TaxID=5855 {ECO:0000313|EMBL:AAF91168.1};
RN [1] {ECO:0000313|EMBL:AAF91168.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=P3 {ECO:0000313|EMBL:AAF91168.1};
RX PubMed=10960170; DOI=10.1016/S0166-6851(00)00238-3;
RA Putaporntip C., Jongwutiwes S., Seethamchai S., Kanbara H., Tanabe K.;
RT "Intragenic recombination in the 3' portion of the merozoite surface
RT protein 1 gene of Plasmodium vivax.";
RL Mol. Biochem. Parasitol. 109:111-119(2000).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004609};
CC Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004609}. Membrane
CC {ECO:0000256|ARBA:ARBA00004589}; Lipid-anchor, GPI-anchor
CC {ECO:0000256|ARBA:ARBA00004589}.
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DR EMBL; AF199405; AAF91168.1; -; Genomic_DNA.
DR AlphaFoldDB; Q9NCM4; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 2.10.25.10; Laminin; 2.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR010901; MSP1_C.
DR InterPro; IPR024730; MSP1_EGF_1.
DR Pfam; PF12947; EGF_3; 1.
DR Pfam; PF12946; EGF_MSP1_1; 1.
DR Pfam; PF07462; MSP1_C; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Merozoite {ECO:0000313|EMBL:AAF91168.1};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 559..584
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..413
FT /note="Merozoite surface 1 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07462"
FT DOMAIN 483..519
FT /note="Merozoite surface protein EGF"
FT /evidence="ECO:0000259|Pfam:PF12946"
FT DOMAIN 526..565
FT /note="EGF"
FT /evidence="ECO:0000259|Pfam:PF12947"
FT REGION 131..152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 326..397
FT /evidence="ECO:0000256|SAM:Coils"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AAF91168.1"
SQ SEQUENCE 588 AA; 65864 MW; 85A18A37D50C15BA CRC64;
YYKARAKYYI GEPFPLKTLS EESMQKEDNY LNLEKFRVLS RLEGRLGKNI ELEKENISYL
SSGLHHVLTE LKEIIKNKKY SGNDHTKNIA AVKEALQAYQ ELIPKVTTQE STSVAVTVPG
AVVPGVPTAA AAGSGASGAV PPATGPGAAA GSTEENVAAK AQDYAEDYDK VIALPLFGNN
DDDWEEDQVT TGEAESEEPE ILVPAGISDY DVVYLKPLAG MYKTIKKQLE NHVNAFNTNI
TDMLDSRLKK RNYFLEVLNS DLNPFKYSSS GEYIIKDPYK LLDLEKKKKL LGSYKYIGAS
IDKDLATAND GVAYYNKMEE LYKTHLTAVN AQIKKVEDDI KKQDEELKKI ENEANKTAEK
AKFTAKKAEL EKYLPFLNSL QKEYESLVSK VNTYTDNLKK VISNCQLEKK EAEITVKKLQ
DYNKMDEKLE EYKKSEKKNE VKSSGLLERL MKSKLIKENE SKEILSQLLN VQTQLLTMSS
EHTCIDTNVP DNAACYRYLD GTEEWRCLLT FKEEGGKCVP ASNVTCKDNN GGCAPEAECK
MTDSNKIVCK CTKEGSEPLF EGVFCSSSSF LSLSFLLLML LFLLCMEL
//
