ID Q9NDU0_DROSI Unreviewed; 346 AA.
AC Q9NDU0;
DT 01-OCT-2000, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2000, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=Regulatory protein zeste {ECO:0000256|ARBA:ARBA00016807};
GN Name=prod {ECO:0000313|EMBL:BAA95159.1};
OS Drosophila simulans (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7240 {ECO:0000313|EMBL:BAA95159.1};
RN [1] {ECO:0000313|EMBL:BAA95159.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=gfBx {ECO:0000313|EMBL:BAA95159.1};
RX PubMed=10897796; DOI=10.1023/A:1003953518269;
RA Itoh M., Yu S., Watanabe T.K., Yamamoto M.T.;
RT "Structural and genetic studies of the proliferation disrupter genes of
RT Drosophila simulans and D. melanogaster.";
RL Genetica 106:223-229(1999).
CC -!- FUNCTION: Involved in transvection phenomena (= synapsis-dependent gene
CC expression), where the synaptic pairing of chromosomes carrying genes
CC with which zeste interacts influences the expression of these genes.
CC Zeste binds to DNA and stimulates transcription from a nearby promoter.
CC {ECO:0000256|ARBA:ARBA00025466}.
CC -!- SUBUNIT: Self-associates forming complexes of several hundred monomers.
CC {ECO:0000256|ARBA:ARBA00011764}.
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DR EMBL; AB018792; BAA95159.1; -; Genomic_DNA.
DR AlphaFoldDB; Q9NDU0; -.
DR GO; GO:0000791; C:euchromatin; IEA:EnsemblMetazoa.
DR GO; GO:0005721; C:pericentric heterochromatin; IEA:EnsemblMetazoa.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0048542; P:lymph gland development; IEA:EnsemblMetazoa.
DR GO; GO:0007076; P:mitotic chromosome condensation; IEA:EnsemblMetazoa.
DR GO; GO:0042752; P:regulation of circadian rhythm; IEA:EnsemblMetazoa.
DR InterPro; IPR028002; Myb_DNA-bind_5.
DR Pfam; PF13873; Myb_DNA-bind_5; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125}.
FT DOMAIN 8..84
FT /note="Myb/SANT-like DNA-binding"
FT /evidence="ECO:0000259|Pfam:PF13873"
FT REGION 285..308
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 292..308
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 346 AA; 39424 MW; E12459D8A1D38024 CRC64;
MNGKMDRRKK RTSSEQYQMY IDMMESDPIF ATGRVPRDYD LNYLTKKWKE LSDRLNKCSS
GPTLTPEEWR KRLNDWKNTT RCKYRRSLLS TEKDISMTSV ETRALDLFGK VPTTGGETMI
NLKSEKDEHD DEMEELGQRT SAAFQKELQA AVEEAINDEV DEEEMVEEHV DHEDMMEENL
AETGITASTT AVNTGGGTYR TIVVDNTSFE HVEEEAQTVQ PHAVEYVTSR RPAAAVINPG
TASSGNKLIN GELPVKRMRT QPREQIIYEV KNATRCISNM QAVPPLHSTK LEREPSSLTS
ALSSSDAQQI AHQRKRLANI KYETLQFEIA RFKFNNPGFQ YDPPSL
//
