ID Q9NGZ2_DROME Unreviewed; 350 AA.
AC Q9NGZ2;
DT 01-OCT-2000, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2000, sequence version 1.
DT 22-FEB-2023, entry version 96.
DE SubName: Full=Tunen {ECO:0000313|EMBL:AAF36412.1};
GN Name=wun2 {ECO:0000313|FlyBase:FBgn0041087};
GN ORFNames=CG8805 {ECO:0000313|FlyBase:FBgn0041087};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AAF36412.1};
RN [1] {ECO:0000313|EMBL:AAF36412.1}
RP NUCLEOTIDE SEQUENCE.
RA Hayden A.M., Howard K.R.;
RT "Molecular cloning and functional characterization of Drosophila Tunen a
RT homolog of the germ cell guidance factor Wunen.";
RL Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the PA-phosphatase related phosphoesterase
CC family. {ECO:0000256|ARBA:ARBA00008816}.
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DR EMBL; AF236058; AAF36412.1; -; mRNA.
DR AlphaFoldDB; Q9NGZ2; -.
DR AGR; FB:FBgn0041087; -.
DR FlyBase; FBgn0041087; wun2.
DR VEuPathDB; VectorBase:FBgn0041087; -.
DR ExpressionAtlas; Q9NGZ2; baseline and differential.
DR GO; GO:0045177; C:apical part of cell; IDA:FlyBase.
DR GO; GO:0005886; C:plasma membrane; IDA:FlyBase.
DR GO; GO:0042577; F:lipid phosphatase activity; IDA:FlyBase.
DR GO; GO:0005319; F:lipid transporter activity; IDA:FlyBase.
DR GO; GO:0008195; F:phosphatidate phosphatase activity; ISS:FlyBase.
DR GO; GO:0035234; P:ectopic germ cell programmed cell death; TAS:FlyBase.
DR GO; GO:0007281; P:germ cell development; IMP:FlyBase.
DR GO; GO:0008354; P:germ cell migration; IMP:FlyBase.
DR GO; GO:0035233; P:germ cell repulsion; IGI:FlyBase.
DR GO; GO:0046839; P:phospholipid dephosphorylation; IBA:GO_Central.
DR GO; GO:0006644; P:phospholipid metabolic process; IBA:GO_Central.
DR GO; GO:0007277; P:pole cell development; IMP:FlyBase.
DR GO; GO:0007280; P:pole cell migration; IMP:FlyBase.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR CDD; cd03384; PAP2_wunen; 1.
DR Gene3D; 1.20.144.10; Phosphatidic acid phosphatase type 2/haloperoxidase; 1.
DR InterPro; IPR036938; P_Acid_Pase_2/haloperoxi_sf.
DR InterPro; IPR000326; P_Acid_Pase_2/haloperoxidase.
DR InterPro; IPR043216; PA_PP_rel.
DR PANTHER; PTHR10165:SF197; FI04477P-RELATED; 1.
DR PANTHER; PTHR10165; LIPID PHOSPHATE PHOSPHATASE; 1.
DR Pfam; PF01569; PAP2; 1.
DR SMART; SM00014; acidPPc; 1.
DR SUPFAM; SSF48317; Acid phosphatase/Vanadium-dependent haloperoxidase; 1.
PE 2: Evidence at transcript level;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 87..111
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 138..158
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 298..318
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 330..349
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 196..346
FT /note="Phosphatidic acid phosphatase type 2/haloperoxidase"
FT /evidence="ECO:0000259|SMART:SM00014"
FT REGION 15..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 350 AA; 39442 MW; F498E87C1E928641 CRC64;
MSTLRPVSVC DTTPLQRFES QSSSGEEPSS PTASSIIAAA SGPNHNNNNN VKLDLQLPTF
VDSTRSQGSL YAVASNKKPP LRGPRQIFGR ILTDLCLLSC VGLPMLGFSL WGEAVKRGFF
CDDSSLRHPY RDSTMPSWIL YLMCGALPLT VMLVVEFFRG QDKRLHSPFP KSTMCSGYHL
CHLELPTWLV ECYHRMGIFI FGLGVEQLST NIAKYSIGRL RPHFYTLCQP VMKDGTTCSD
PINAARYIED FTCAAVDITS KQLKDMRLSF PSGHASFACY SMLYLVIYLH RRMQWKQLRM
LCHLLQFLLL MFAWYTALTR VSDYKHHWSD VLAGSGIGLT YAVVVTSTMW
//