ID Q9NZS3_HUMAN Unreviewed; 1066 AA.
AC Q9NZS3;
DT 01-OCT-2000, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2000, sequence version 1.
DT 24-JAN-2024, entry version 93.
DE RecName: Full=histone deacetylase {ECO:0000256|ARBA:ARBA00012111};
DE EC=3.5.1.98 {ECO:0000256|ARBA:ARBA00012111};
DE Flags: Fragment;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|EMBL:AAF36540.1};
RN [1] {ECO:0000313|EMBL:AAF36540.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Placenta {ECO:0000313|EMBL:AAF36540.1};
RA Govindan M.V., Warriar N.;
RT "Human GR AF-1 specific histone deacetylase.";
RL Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the histone deacetylase family. HD type 2
CC subfamily. {ECO:0000256|ARBA:ARBA00007738}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF174499; AAF36540.1; -; mRNA.
DR AlphaFoldDB; Q9NZS3; -.
DR GO; GO:0000118; C:histone deacetylase complex; IEA:InterPro.
DR GO; GO:0019899; F:enzyme binding; IEA:UniProt.
DR GO; GO:0004407; F:histone deacetylase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0010605; P:negative regulation of macromolecule metabolic process; IEA:UniProt.
DR CDD; cd10003; HDAC6-dom2; 1.
DR Gene3D; 3.40.800.20; Histone deacetylase domain; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR000286; His_deacetylse.
DR InterPro; IPR023801; His_deacetylse_dom.
DR InterPro; IPR037138; His_deacetylse_dom_sf.
DR InterPro; IPR017320; Histone_deAcase_II_euk.
DR InterPro; IPR023696; Ureohydrolase_dom_sf.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR001607; Znf_UBP.
DR PANTHER; PTHR45364:SF8; HISTONE DEACETYLASE 5; 1.
DR PANTHER; PTHR45364; HISTONE DEACETYLASE 9-RELATED; 1.
DR Pfam; PF00850; Hist_deacetyl; 2.
DR Pfam; PF02148; zf-UBP; 1.
DR PRINTS; PR01270; HDASUPER.
DR SMART; SM00290; ZnF_UBP; 1.
DR SUPFAM; SSF52768; Arginase/deacetylase; 2.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50271; ZF_UBP; 1.
PE 2: Evidence at transcript level;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00502};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00502};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00502}.
FT DOMAIN 962..1060
FT /note="UBP-type"
FT /evidence="ECO:0000259|PROSITE:PS50271"
FT REGION 694..714
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 875..898
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AAF36540.1"
SQ SEQUENCE 1066 AA; 114285 MW; 7001E35AAC093346 CRC64;
NSGMETTQYM NEGELRVLAD TYDSVYLHPN SYSCACLASG SVLRLVDAVL GAEIRNGMAI
IRPPGHHAQH SLMDGYCMFN HVAVAARYAQ QKHRIRRVLI LDWDVHHGQG TQFTFDQDPS
VLYFSIHRYE QGRFWPHLKA SNWSTTGFGQ GQGYTINVPW NQVGMRDADY IAAFLHVLLP
VALEFQPQLV LVAAGFDALQ GDPKGEMAAT PAGFAQLTHL LMGLAGGKLI LSLEGGYNLR
ALAEGVSASL HTLLGDPGPM LESPGAPCRS AQASVSCALE ALEPFWEVLV RSTETVERGH
MGEDNVEESE EEGPWEPPVL PILTWPVLTS RTGLVYDQNM MNHCNLWDSH HPEVPQRILR
IMCRLEELGL AGRCLTLTPR PATEAELLTC HSAEYVGHLR ATEKMKTREL HRESSNFDSI
YICPSTFACA QLATGAACRL VEAVLSGEVL NGAAVVRPPG HHAEQDAACG FCFFNSVAVA
ARHAQTISGH ALRILIVDWD VHHGNGTQHM FEDDPSVLYV SLHRYDHGTF FPMGDEGASS
QIGRAAGTGF TVNVAWNGPR MGDADYLAAW HRLVLPIAYE FNPELVLVSA GFDAARGDPL
GGCQVSPEGY AHLTHLLMGL ASGRIILILE GGYNLTSISE SMAACTRSLL GDPPPLLTLP
RPPLSGALAS ITETIQVHAR YWCSLRVMKV EDREGPSSSK LVTKKAPQPA KPRLAERMTT
REKKVLEAGM GKVTSASFGE ESTPGQTNSE TAVVALTQDQ PSEAATGGAT LAQTISEAAI
GGAMLGQTTS EEAVGGATPD QTTSEETVGG AILDQTTSED AVGGATLGQT TSEEAVGGAT
LAQTISEAAM EGATLDQTTS EEAPGGTELI QTPLASSTDH QTPPTSPGQG TTPQISPSTL
IGSLRTLELG SESQGASESQ APGEENLLGE AAGGQDMADS MLMQGSRGLT DQAIFYAVTP
LPWCPHLVAV CPIPAAGLDV TQPCGDCGTI QENWVCLSCY QVYCGRYING HMLQHHGNSG
HPLVLSYIDL SAWCYYCQAY VHHQALLDVK NIAHQNKFGE DMPHPH
//