ID   Q9P388_NEUCS            Unreviewed;      1071 AA.
AC   Q9P388;
DT   01-OCT-2000, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2000, sequence version 1.
DT   27-MAR-2024, entry version 64.
DE   SubName: Full=Related to small s protein {ECO:0000313|EMBL:CAB99388.1};
GN   Name=B24M22.200 {ECO:0000313|EMBL:CAB99388.1};
GN   ORFNames=GE21DRAFT_3580 {ECO:0000313|EMBL:KHE82920.1};
OS   Neurospora crassa.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=5141 {ECO:0000313|EMBL:CAB99388.1};
RN   [1] {ECO:0000313|EMBL:CAB99388.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Schulte U., Aign V., Hoheisel J., Brandt P., Fartmann B., Holland R.,
RA   Nyakatura G., Mewes H.W., Mannhaupt G.;
RL   Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:CAB99388.1}
RP   NUCLEOTIDE SEQUENCE.
RA   German Neurospora genome project;
RL   Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:KHE82920.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=73 {ECO:0000313|EMBL:KHE82920.1};
RG   DOE Joint Genome Institute;
RA   Baker S.E., Grigoriev I., Haridas S., LaButti K., McCluskey K.;
RT   "Draft genome sequence of Neurospora crassa strain FGSC 73.";
RL   Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; AL390354; CAB99388.1; -; Genomic_DNA.
DR   EMBL; KN389698; KHE82920.1; -; Genomic_DNA.
DR   PIR; T51224; T51224.
DR   VEuPathDB; FungiDB:NCU08705; -.
DR   eggNOG; ENOG502RTJ4; Eukaryota.
DR   HOGENOM; CLU_002341_2_0_1; -.
DR   OrthoDB; 2373501at2759; -.
DR   Proteomes; UP000053122; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 1.20.120.1020; Prion-inhibition and propagation, HeLo domain; 1.
DR   InterPro; IPR029498; HeLo_dom.
DR   InterPro; IPR038305; HeLo_sf.
DR   InterPro; IPR007111; NACHT_NTPase.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR10039; AMELOGENIN; 1.
DR   PANTHER; PTHR10039:SF5; NACHT DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF14479; HeLo; 1.
DR   Pfam; PF05729; NACHT; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        1044..1061
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          5..203
FT                   /note="Prion-inhibition and propagation HeLo"
FT                   /evidence="ECO:0000259|Pfam:PF14479"
FT   DOMAIN          289..475
FT                   /note="NACHT"
FT                   /evidence="ECO:0000259|Pfam:PF05729"
FT   REGION          1013..1033
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1071 AA;  120744 MW;  EF954CFB6CE5B8D2 CRC64;
     MEPVGLAIGV IGLAGVFKSC VELFGYFSTY RSYGHDYSLL DAKLHVEKAF LLLWADRVRL
     LHEDYDRRLD NPTIREAVSH ILSSITHLLS ETSSLQQRYG VEQRDGPHSQ LLVSQSSTVG
     ASLKEKFKND YNAMQLRIHH RKATTSTSDK LRWMIVDKDK FNTLIAELSH FTSKLDALLP
     GDSSERTVSL LASLIRNEVL SVYKENAKLL PQQAADGRLE GNDILQEARD QDRALKSLWF
     RCMDDRKDSV SPAHVKTLQW ALKPACKREG YEAEWDDLSE WLRSGTGVYW ICGKAGSGKS
     TLMKYLHDNP DTRAPLQAWA GDLPLTVGSF FFWGLGTQEQ KSLEGLSRAI LYRLLEAESS
     YLPSALPRLW QEVRINAHKE PDPPSSGELR TASEFMTKKF QPKHRFCLFI DGLDEFQGNF
     HDAIKLIRGL CSNPAIKVIV SSRPIAICYH AFSRVPQLHM ESLTRNDIKE YINDVIGSHD
     YMEVLVDSGE QSPNIITHKL IEKASGVFLW VILACRSILD GFAASDTVAE LCQRVDDLPP
     ELEDLFVHML NSVDRRYHEQ MAKTLKILYT QVASTYSREG LTIKLASFDR NGMDCASNHP
     LESFPVHEAP KICSAMVARL RSRCGGLLQV EPRFDWGKQS RSDADSNLDI CWCPSRETCP
     WIKQEDHNSS LLTHKSGGFP EHSDIDFIHR TVFEFLDNPK VWDLAPLRIS DPTFSVACAL
     AGMDLQLSYL YCQNGARLSG SFKELFAIDH EPLESVLPVL AKLADCLSLT IPREHYATNE
     AALQSCFSRF LDPAYNRSSL QLSLLLAVEV GLVNTVGRLL QDVRLRPPSA PFSPFPLLYH
     ALILPFLFDF DHVWLFISRP LHELLEYLLS QDFSPNEVFV NERGLSTTPW RELVLKGQRH
     FESFHADSAL FVVMFPFKAM KPLVEHGAEL DNVLPGIPIM EKFLDDAFAR FGIGRYKKAE
     LNKRDLEVKD SLMAAIANRR RVMAAEALAS STASEQSNET VTQLDDSLGA QIDEKLDGNN
     NKADTESSPK LDTGRKVHLK PLQAPLWWLL LFAILALSIY MKPGLLSQAG S
//