ID Q9PR73_UREPA Unreviewed; 442 AA.
AC Q9PR73;
DT 01-OCT-2000, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2000, sequence version 1.
DT 27-MAR-2024, entry version 97.
DE SubName: Full=Hemolysin {ECO:0000313|EMBL:AAF30477.1};
GN Name=hlyC {ECO:0000313|EMBL:AAF30477.1};
GN OrderedLocusNames=UU072 {ECO:0000313|EMBL:AAF30477.1};
OS Ureaplasma parvum serovar 3 (strain ATCC 700970).
OC Bacteria; Mycoplasmatota; Mycoplasmoidales; Mycoplasmoidaceae; Ureaplasma.
OX NCBI_TaxID=273119 {ECO:0000313|EMBL:AAF30477.1, ECO:0000313|Proteomes:UP000000423};
RN [1] {ECO:0000313|EMBL:AAF30477.1, ECO:0000313|Proteomes:UP000000423}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700970 {ECO:0000313|EMBL:AAF30477.1,
RC ECO:0000313|Proteomes:UP000000423};
RX PubMed=11048724; DOI=10.1038/35037619;
RA Glass J.I., Lefkowitz E.J., Glass J.S., Heiner C.R., Chen E.Y.,
RA Cassell G.H.;
RT "The complete sequence of the mucosal pathogen Ureaplasma urealyticum.";
RL Nature 407:757-762(2000).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AF222894; AAF30477.1; -; Genomic_DNA.
DR RefSeq; WP_006688709.1; NC_002162.1.
DR AlphaFoldDB; Q9PR73; -.
DR SMR; Q9PR73; -.
DR STRING; 273119.UU072; -.
DR EnsemblBacteria; AAF30477; AAF30477; UU072.
DR GeneID; 29672133; -.
DR KEGG; uur:UU072; -.
DR PATRIC; fig|273119.6.peg.74; -.
DR eggNOG; COG1253; Bacteria.
DR HOGENOM; CLU_015237_4_1_14; -.
DR OrthoDB; 9798188at2; -.
DR Proteomes; UP000000423; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR CDD; cd04590; CBS_pair_CorC_HlyC_assoc; 1.
DR Gene3D; 3.10.580.10; CBS-domain; 1.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR002550; CNNM.
DR InterPro; IPR044751; Ion_transp-like_CBS.
DR PANTHER; PTHR22777; HEMOLYSIN-RELATED; 1.
DR PANTHER; PTHR22777:SF33; UPF0053 PROTEIN YEGH; 1.
DR Pfam; PF00571; CBS; 2.
DR Pfam; PF01595; CNNM; 1.
DR SMART; SM00116; CBS; 2.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR PROSITE; PS51371; CBS; 2.
DR PROSITE; PS51846; CNNM; 1.
PE 4: Predicted;
KW CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU01193}; Reference proteome {ECO:0000313|Proteomes:UP000000423};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU01193};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|PROSITE-
KW ProRule:PRU01193}.
FT TRANSMEM 15..37
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 79..104
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 116..137
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 149..169
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 16..207
FT /note="CNNM transmembrane"
FT /evidence="ECO:0000259|PROSITE:PS51846"
FT DOMAIN 226..285
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 289..348
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
SQ SEQUENCE 442 AA; 50247 MW; 328E525BB1A2C4DD CRC64;
MIEDSQETIS TQANFSVGIL VILAIITLIL ICFSVFFSAA ETAITSVTTV KWKTESNKIK
SKTITNVVYK MINNYTITLA TILIGNTLVN TASSTIAGLF FAGIMKSFST TSNAEAIGTG
IATGIITLIV LIFGEFIPKN FAKKNPIKVL KLVAYPLNCF YILFWPLTWS LNRIFNKKSQ
NIITATEEEL KSLIEVIRHE GTLDSQEALI INKAILFDDI LIKQKMVPWT QVVKINENKT
VLQSFEIFNS TGFSRLVVVN KNDEVVGIIY LKKIIKYLLN EPNKIIRTIM QTPLLINQKD
TLYDGLRTMQ FQRIHLGIVV DNITEKNPIG IITLENITEE LTGNVYDETD NENEIKEIQI
VNETTWRVDA KTNAKLFLHQ YIDKDIEVND DISMGKYISK INKNRAFKNR QLINTPNMYI
ETFKDVRTNQ FAFLIEKKIN QS
//
