ID Q9PW79_CHICK Unreviewed; 368 AA.
AC Q9PW79;
DT 01-MAY-2000, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2000, sequence version 1.
DT 27-MAR-2024, entry version 96.
DE SubName: Full=TvbS3 {ECO:0000313|EMBL:AAD47256.1};
GN Name=tvb {ECO:0000313|EMBL:AAD47256.1};
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031 {ECO:0000313|EMBL:AAD47256.1};
RN [1] {ECO:0000313|EMBL:AAD47256.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=8945512; DOI=10.1016/S0092-8674(00)81992-3;
RA Brojatsch J., Naughton J., Rolls M.M., Zingler K., Young J.A.;
RT "CAR1, a TNFR-related protein, is a cellular receptor for cytopathic avian
RT leukosis-sarcoma viruses and mediates apoptosis.";
RL Cell 87:845-855(1996).
RN [2] {ECO:0000313|EMBL:AAD47256.1}
RP NUCLEOTIDE SEQUENCE.
RA Brojatsch J., Naughton J., Young J.A.T.;
RL Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter
CC molecule FADD recruits caspase-8 to the activated receptor. The
CC resulting death-inducing signaling complex (DISC) performs caspase-8
CC proteolytic activation which initiates the subsequent cascade of
CC caspases (aspartate-specific cysteine proteases) mediating apoptosis.
CC {ECO:0000256|PIRNR:PIRNR037867}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00206}.
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DR EMBL; AF161712; AAD47256.1; -; mRNA.
DR AlphaFoldDB; Q9PW79; -.
DR VEuPathDB; HostDB:geneid_373904; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0045569; F:TRAIL binding; IEA:UniProtKB-UniRule.
DR GO; GO:0036462; P:TRAIL-activated apoptotic signaling pathway; IEA:UniProtKB-UniRule.
DR CDD; cd08315; Death_TRAILR_DR4_DR5; 1.
DR CDD; cd10580; TNFRSF10; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 2.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR InterPro; IPR020465; TNFR_10.
DR InterPro; IPR034024; TNFRSF10_N.
DR InterPro; IPR034029; TNFRSF10A/B_death.
DR PANTHER; PTHR46330:SF16; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 10A; 1.
DR PANTHER; PTHR46330; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 10B; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF00020; TNFR_c6; 2.
DR PIRSF; PIRSF037867; CD261_antigen; 1.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00208; TNFR; 2.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF57586; TNF receptor-like; 2.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS50050; TNFR_NGFR_2; 2.
PE 2: Evidence at transcript level;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703, ECO:0000256|PIRNR:PIRNR037867};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00206}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR037867};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|PIRNR:PIRNR037867};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|PIRNR:PIRNR037867};
KW Transmembrane {ECO:0000256|PIRNR:PIRNR037867};
KW Transmembrane helix {ECO:0000256|PIRNR:PIRNR037867}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|PIRNR:PIRNR037867"
FT CHAIN 25..368
FT /evidence="ECO:0000256|PIRNR:PIRNR037867"
FT /id="PRO_5024528107"
FT TRANSMEM 156..177
FT /note="Helical"
FT /evidence="ECO:0000256|PIRNR:PIRNR037867"
FT DOMAIN 58..101
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT REPEAT 58..101
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DOMAIN 102..143
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT REPEAT 102..143
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DOMAIN 288..357
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT DISULFID 80..93
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 83..101
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 103..118
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 125..143
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
SQ SEQUENCE 368 AA; 41516 MW; F558C225AB3750BB CRC64;
MRSAALRLCP VLLLLFAEVQ LGSAAAVKKR ADRSDLQKPD LYRRKCPMGT YEANDSIQCL
PSKKDEYTEY PNDFPKCLGC RTCREDQVEV SPCIPTRNTQ CACKNGTFCL PDHPCEMCQK
CQTECPKGQV RLAPCTQHSD LLCGPPLEIS SSSSTLWIII TFTVLLAVIL GLVLVFWKRC
SSRHHGAGDD GELSWKPSAV VNRLLQRLGI QDNRCNEQIY QNQQQQELLF TAQGSEVPHG
VEMEGTERRT PDPKVETQRK LVPVLGENPI ALLHRSFNTF VDYVPFPEWK RFGRALDLQE
NDLYLAEQHD RVSCEPFYQM LNTWLNQQGS KASVNTLLET LPRIGLSGVA DIIASELISK
GYFQYEVS
//
