ID   Q9PWE1_ICTPU            Unreviewed;       977 AA.
AC   Q9PWE1;
DT   01-MAY-2000, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2000, sequence version 1.
DT   27-MAR-2024, entry version 90.
DE   SubName: Full=Metabotropic glutamate receptor {ECO:0000313|EMBL:AAD47893.1};
DE   Flags: Fragment;
GN   Name=GLUR {ECO:0000313|EMBL:AAD47893.1};
OS   Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC   Ictaluridae; Ictalurus.
OX   NCBI_TaxID=7998 {ECO:0000313|EMBL:AAD47893.1};
RN   [1] {ECO:0000313|EMBL:AAD47893.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Retina {ECO:0000313|EMBL:AAD47893.1};
RA   Hellmich H.L., Micci A.M., Sanchez X., Christensen B.N.;
RT   "Molecular cloning, functional expression and localization of a novel
RT   metabotropic glutamate receptor linked to calcium mobilization from the
RT   catfish retina.";
RL   Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family.
CC       {ECO:0000256|ARBA:ARBA00007242}.
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DR   EMBL; AF076473; AAD47893.1; -; mRNA.
DR   AlphaFoldDB; Q9PWE1; -.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   CDD; cd06376; PBP1_mGluR_groupIII; 1.
DR   Gene3D; 3.40.50.2300; -; 2.
DR   Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR   InterPro; IPR001828; ANF_lig-bd_rcpt.
DR   InterPro; IPR000337; GPCR_3.
DR   InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR   InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR   InterPro; IPR017978; GPCR_3_C.
DR   InterPro; IPR017979; GPCR_3_CS.
DR   InterPro; IPR001786; GPCR_3_mGluR4.
DR   InterPro; IPR000162; GPCR_3_mtglu_rcpt.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   PANTHER; PTHR24060; METABOTROPIC GLUTAMATE RECEPTOR; 1.
DR   PANTHER; PTHR24060:SF24; METABOTROPIC GLUTAMATE RECEPTOR 6; 1.
DR   Pfam; PF00003; 7tm_3; 1.
DR   Pfam; PF01094; ANF_receptor; 1.
DR   Pfam; PF07562; NCD3G; 1.
DR   PRINTS; PR00248; GPCRMGR.
DR   PRINTS; PR01054; MTABOTROPC4R.
DR   PRINTS; PR00593; MTABOTROPICR.
DR   SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR   PROSITE; PS00979; G_PROTEIN_RECEP_F3_1; 1.
DR   PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR   PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:AAD47893.1};
KW   Transducer {ECO:0000256|ARBA:ARBA00023224};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        617..643
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        655..675
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        729..750
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        781..802
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        814..836
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          617..841
FT                   /note="G-protein coupled receptors family 3 profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50259"
FT   REGION          915..949
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        915..931
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         977
FT                   /evidence="ECO:0000313|EMBL:AAD47893.1"
SQ   SEQUENCE   977 AA;  108760 MW;  BD06A67E240751CE CRC64;
     MASHSPPSPL LDLRLQPSWT GRHSPTWPRL LWIFCVCVSP ALMAHQHTHP HSIKIPGDVT
     LGGLFPVHSK GPLGQACGEI KKEKGVHRME AMLYALDQIN SDPELLPNIT LGTRILDTCS
     RDTYALEQSL TFVQALIQKD TSDIRCSNGE QPIIRKPERV VGVIGASASS VSIMVANVLR
     LFEIPQISYA STAPELSDNN RYDFFSRVVP PDSYQAQAMV DIVKALGWNY VFILASEGNY
     GESGVDAFVQ ISREAGGLCI AQSMKIPRDP KPGEFDKIIK RLMETPNARG IIIFANEDDI
     KQVLEAARRA NLTGHFKFVG SDSWGAKSAP ILDNEEVAEG AVTILPKRAS VEGFDQYFTS
     RSLENNRRNI WFAEFWEDDF RCKLTRPGIK LDPEKKKCTG KERIGRDSPY EQEGKVQFVI
     DAVYAMAHAL HNMHQTCARG RGTLCKMDPV EGRLLLSYIR AVNFNGSAGT GVLFNENGDA
     PGRYDIFQYQ FSNTSSPGYK VIGQSFSISS AKTSSPGYKV FGQWTNNLGI NEVEEMQWSG
     GEHYIPASVC SFPCQPGERK KMVKGVPCCW HCEPCDGYQY QVGELTCEMC PFDMRPTANH
     TACTPTPIIK LDWHSPWAVV PMFLAILGIA ATLSVVIVFV RFNDTPIVRA SGRELSYVLL
     TGIFLIYLIT FLMIAEPNTV VCALRRLLLG LGMCITYSAM LTKTNRIYRI FEQGKKSVTA
     PKFISPTSQL VITFILVSFQ VIGVFIWFGV VPPHTIVDYD ELRPPNPELA RGILKCDMSD
     LSLICCLSYS ILLMVTCTVY AVKSRGVPET FNEAKPIGFT MYTTCIVWLA FVPIFFGTAQ
     SHGEDVHPDD HADRVHEPEC LRVPWACSTS LKCTSSSFTR SRMCRNASAA SRLWFRRPPC
     PLVCHTPTAK STTARLRWSQ TGRSSRWPGA THSANPDGRK VEGKESKTPL SRFPFADFYK
     EDSEARTSKP CKRGSKN
//