ID Q9PZS0_HCMV Unreviewed; 175 AA.
AC Q9PZS0;
DT 01-MAY-2000, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2000, sequence version 1.
DT 24-JAN-2024, entry version 76.
DE SubName: Full=UL144 {ECO:0000313|EMBL:ACS92215.1, ECO:0000313|EMBL:ACX46758.1};
DE SubName: Full=TNF alpha-like receptor UL144 {ECO:0000313|EMBL:ACD35774.1};
DE SubName: Full=UL144 protein {ECO:0000313|EMBL:AAF09114.1};
GN Name=UL144 {ECO:0000313|EMBL:AAF09114.1};
OS Human cytomegalovirus (HHV-5) (Human herpesvirus 5).
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Orthoherpesviridae; Betaherpesvirinae; Cytomegalovirus;
OC Cytomegalovirus humanbeta5.
OX NCBI_TaxID=10359 {ECO:0000313|EMBL:AAF09114.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:AAF09114.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=10559318;
RA Lurain N.S., Kapell K.S., Huang D.D., Short J.A., Paintsil J.,
RA Winkfield E., Benedict C.A., Ware C.F., Bremer J.W.;
RT "Human cytomegalovirus UL144 open reading frame: sequence hypervariability
RT in low-passage clinical isolates.";
RL J. Virol. 73:10040-10050(1999).
RN [2] {ECO:0000313|EMBL:ADB84776.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=AL {ECO:0000313|EMBL:ADB84776.1};
RX PubMed=15105547; DOI=10.1099/vir.0.79888-0;
RA Dolan A., Cunningham C., Hector R.D., Hassan-Walker A.F., Lee L.,
RA Addison C., Dargan D.J., McGeoch D.J., Gatherer D., Emery V.C.,
RA Griffiths P.D., Sinzger C., McSharry B.P., Wilkinson G.W., Davison A.J.;
RT "Genetic content of wild-type human cytomegalovirus.";
RL J. Gen. Virol. 85:1301-1312(2004).
RN [3] {ECO:0000313|EMBL:ACD35774.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=100751 {ECO:0000313|EMBL:ACD35774.1}, 101329
RC {ECO:0000313|EMBL:ACD35777.1}, and 201370
RC {ECO:0000313|EMBL:ACD35787.1};
RX PubMed=18556037; DOI=10.1016/j.virol.2008.05.002;
RA Heo J., Petheram S., Demmler G., Murph J.R., Adler S.P., Bale J.,
RA Sparer T.E.;
RT "Polymorphisms within human cytomegalovirus chemokine (UL146/UL147) and
RT cytokine receptor genes (UL144) are not predictive of sequelae in
RT congenitally infected children.";
RL Virology 378:86-96(2008).
RN [4] {ECO:0000313|EMBL:ADB84776.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=AL {ECO:0000313|EMBL:ADB84776.1};
RA Davison A.J.;
RL Submitted (MAY-2009) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|EMBL:ACX46758.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CMV_004 {ECO:0000313|EMBL:ACX46758.1}, CMV_027
RC {ECO:0000313|EMBL:ACX46779.1}, CMV_067 {ECO:0000313|EMBL:ACX46809.1},
RC CMV_074 {ECO:0000313|EMBL:ACX46815.1}, and CMV_087
RC {ECO:0000313|EMBL:ACX46827.1};
RX PubMed=20810771; DOI=10.1128/JCM.01133-10;
RA Waters A., Hassan J., Degascun C., Kissoon G., Knowles S., Molloy E.,
RA Connell J., Hall W.W.;
RT "Human cytomegalovirus UL144 is associated with viremia and infant
RT development sequelae in congenital infection.";
RL J. Clin. Microbiol. 48:3956-3962(2010).
RN [6] {ECO:0000313|EMBL:ACS92215.1, ECO:0000313|Proteomes:UP000135152}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP {ECO:0000313|EMBL:ACS92215.1};
RX PubMed=19906940; DOI=10.1099/vir.0.015891-0;
RA Cunningham C., Gatherer D., Hilfrich B., Baluchova K., Dargan D.J.,
RA Thomson M., Griffiths P.D., Wilkinson G.W., Schulz T.F., Davison A.J.;
RT "Sequences of complete human cytomegalovirus genomes from infected cell
RT cultures and clinical specimens.";
RL J. Gen. Virol. 91:605-615(2010).
RN [7] {ECO:0000313|EMBL:AFR55944.1, ECO:0000313|Proteomes:UP000097205}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HAN19 {ECO:0000313|EMBL:AFR55944.1};
RA Davison A.J.;
RT "Human cytomegalovirus RL11 gene family: variation, recombination and
RT transcription.";
RL Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases.
RN [8] {ECO:0000313|Proteomes:UP000116855, ECO:0000313|Proteomes:UP000126900}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BE/14/2010 {ECO:0000313|EMBL:AKI22381.1}, BE/2/2010
RC {ECO:0000313|EMBL:AKI21714.1}, BE/4/2010
RC {ECO:0000313|EMBL:AKI23550.1}, BE/49/2011
RC {ECO:0000313|EMBL:AKI23052.1}, and BE/8/2011
RC {ECO:0000313|EMBL:AKI10189.1};
RX PubMed=25972543;
RA Sijmons S., Thys K., Mbong Ngwese M., Van Damme E., Dvorak J.,
RA Van Loock M., Li G., Tachezy R., Busson L., Aerssens J., Van Ranst M.,
RA Maes P.;
RT "High-throughput analysis of human cytomegalovirus genome diversity
RT highlights the widespread occurrence of gene-disrupting mutations and
RT pervasive recombination.";
RL J. Virol. 89:7673-7695(2015).
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DR EMBL; AF084994; AAF09114.1; -; Genomic_DNA.
DR EMBL; EU514855; ACD35774.1; -; Genomic_DNA.
DR EMBL; EU514858; ACD35777.1; -; Genomic_DNA.
DR EMBL; EU514868; ACD35787.1; -; Genomic_DNA.
DR EMBL; GQ221975; ACS92215.1; -; Genomic_DNA.
DR EMBL; GQ855963; ACX46758.1; -; Genomic_DNA.
DR EMBL; GQ855984; ACX46779.1; -; Genomic_DNA.
DR EMBL; GQ856014; ACX46809.1; -; Genomic_DNA.
DR EMBL; GQ856020; ACX46815.1; -; Genomic_DNA.
DR EMBL; GQ856032; ACX46827.1; -; Genomic_DNA.
DR EMBL; GQ222015; ADB84776.1; -; Genomic_DNA.
DR EMBL; JX512205; AFR55944.1; -; Genomic_DNA.
DR EMBL; KP745648; AKI10189.1; -; Genomic_DNA.
DR EMBL; KP745717; AKI21714.1; -; Genomic_DNA.
DR EMBL; KP745721; AKI22381.1; -; Genomic_DNA.
DR EMBL; KP745725; AKI23052.1; -; Genomic_DNA.
DR EMBL; KP745728; AKI23550.1; -; Genomic_DNA.
DR Proteomes; UP000097205; Genome.
DR Proteomes; UP000116855; Genome.
DR Proteomes; UP000126900; Genome.
DR Proteomes; UP000135152; Genome.
DR Proteomes; UP000148714; Genome.
DR Proteomes; UP000158960; Genome.
DR Proteomes; UP000165803; Genome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 2.
DR InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR PANTHER; PTHR46838; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 14; 1.
DR PANTHER; PTHR46838:SF1; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 14; 1.
DR Pfam; PF00020; TNFR_c6; 1.
DR SMART; SM00208; TNFR; 2.
DR SUPFAM; SSF57586; TNF receptor-like; 1.
DR PROSITE; PS00652; TNFR_NGFR_1; 1.
DR PROSITE; PS50050; TNFR_NGFR_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius}; Receptor {ECO:0000313|EMBL:ACD35774.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 133..153
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 58..95
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
SQ SEQUENCE 175 AA; 19382 MW; 9732CE45601B60D4 CRC64;
MKPLVMLICF AVILLQLGVT KVCQHNEVQL GNECCPPCGS GQRVTKVCTD YTSVTCTPCP
NGTYVSGLYN CTDCTQCNVT QVMIRNCTST NNTVCASKNY TSFSISGVQH HKQRQNHTAH
VTVKQGKSGR HTLAWLSLFI FLVGIILLIL YLIAAYRSEK CQQCCSIGKI FYRTL
//
