ID Q9Q8G0_MYXVL Unreviewed; 234 AA.
AC Q9Q8G0;
DT 01-MAY-2000, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2000, sequence version 1.
DT 27-MAR-2024, entry version 101.
DE RecName: Full=Host range factor p28 {ECO:0000256|ARBA:ARBA00039653};
DE AltName: Full=E3 ubiquitin-protein ligase p28 {ECO:0000256|ARBA:ARBA00034917};
GN Name=m143R {ECO:0000313|EMBL:AAF15031.1};
OS Myxoma virus (strain Lausanne) (MYXV).
OC Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC Chitovirales; Poxviridae; Chordopoxvirinae; Leporipoxvirus; Myxoma virus.
OX NCBI_TaxID=31530 {ECO:0000313|EMBL:AAF15031.1, ECO:0000313|Proteomes:UP000000867};
OH NCBI_TaxID=9986; Oryctolagus cuniculus (Rabbit).
RN [1] {ECO:0000313|EMBL:AAF15031.1, ECO:0000313|Proteomes:UP000000867}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Lausanne {ECO:0000313|EMBL:AAF15031.1,
RC ECO:0000313|Proteomes:UP000000867};
RX PubMed=10562494; DOI=10.1006/viro.1999.0001;
RA Cameron C., Hota-Mitchell S., Chen L., Barrett J., Cao J.X., Macaulay C.,
RA Willer D., Evans D., McFadden G.;
RT "The complete DNA sequence of myxoma virus.";
RL Virology 264:298-318(1999).
RN [2] {ECO:0000313|EMBL:AAF15031.1, ECO:0000313|Proteomes:UP000000867}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Lausanne {ECO:0000313|EMBL:AAF15031.1,
RC ECO:0000313|Proteomes:UP000000867};
RX PubMed=16356857; DOI=10.1016/j.immuni.2005.10.003;
RA Johnston J.B., Barrett J.W., Nazarian S.H., Goodwin M., Ricuttio D.,
RA Wang G., McFadden G.;
RT "A poxvirus-encoded pyrin domain protein interacts with ASC-1 to inhibit
RT host inflammatory and apoptotic responses to infection.";
RL Immunity 23:587-598(2005).
CC -!- FUNCTION: RING-finger E3 ubiquitin ligase which catalyzes the formation
CC of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Plays an
CC important role in virulence by acting as an anti-apoptotic factor.
CC {ECO:0000256|ARBA:ARBA00025051}.
CC -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000256|ARBA:ARBA00004192}.
CC -!- SIMILARITY: Belongs to the orthopoxvirus OPG021 family.
CC {ECO:0000256|ARBA:ARBA00034749}.
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DR EMBL; AF170726; AAF15031.1; -; Genomic_DNA.
DR RefSeq; NP_051857.1; NC_001132.2.
DR GeneID; 932208; -.
DR KEGG; vg:932208; -.
DR Proteomes; UP000000867; Segment.
DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016881; F:acid-amino acid ligase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:UniProt.
DR GO; GO:0039526; P:perturbation by virus of host apoptosis; IEA:UniProtKB-KW.
DR CDD; cd16521; RING-HC_MKRN; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR016398; E3_ubiquitin-prot_ligase_p28.
DR InterPro; IPR018004; KilA/APSES_HTH.
DR InterPro; IPR017880; KilA_N.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR45798:SF97; E3 UBIQUITIN-PROTEIN LIGASE ATL44-RELATED; 1.
DR PANTHER; PTHR45798; RING-H2 FINGER PROTEIN ATL61-RELATED-RELATED; 1.
DR Pfam; PF04383; KilA-N; 1.
DR Pfam; PF13639; zf-RING_2; 1.
DR PIRSF; PIRSF003775; E3_ubiquit_lig_p28; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS51301; KILA_N; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Host cytoplasm {ECO:0000256|ARBA:ARBA00023200};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00023323};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Modulation of host cell apoptosis by virus {ECO:0000256|ARBA:ARBA00023323};
KW Reference proteome {ECO:0000313|Proteomes:UP000000867};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 5..110
FT /note="KilA-N"
FT /evidence="ECO:0000259|PROSITE:PS51301"
FT DOMAIN 173..219
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
SQ SEQUENCE 234 AA; 27915 MW; 48E5E4D41F7A0DD6 CRC64;
MDHNVKILDN DYGINIVFLR SNHYINITRL CAPMKKSFTN WKALKNSKYI MNSISIEENI
DIDDLTFRIY KNKYSVYYHG IFVHPKLLKY VLSWISDEYY AKVYSIINAY DENILKNTVL
TLYVNYIYCL KQEDMLYKAI HHRNKTYHRL LKTIPNVVNE YETLYDSYKG EECAICMEPV
YAKPIKSSFF GVLSHCNHVF CIECIDRWKK QNNKCPVCRT IFVSVTKSRF FYKG
//
